The present invention relates to a cutaneous device (2) for the storage and release of molecules, in particular therapeutic molecules, comprising: —a support (6), —a matrix (8) configured to store and release the molecules as a function of the temperature, and —an electro-resistive layer, disposed between the support and the matrix, intended to be subjected to a voltage and comprising at least one thin microporous and/or nanoporous metal layer. The present invention also relates to a transcutaneous delivery device and the corresponding methods of manufacture and use.

This invention provides parasitic millirobots that can effectively adapt to an unstructured environment and coherently interact with diverse objects in order to fulfil various application needs. Particularly, a minimalist millirobot construction strategy by splashing composited agglutinate magnetic spray (M-spray) is adopted, which is capable of self-turning multifarious milli-/centi-objects into parasitic millirobots on-demand. Through taking full advantage of the objects' inherent structure and a covered thin drivable film, the M-spray demonstrates superior handling (from 1-D to 3-D structures) and loading capabilities (up to thousand-fold and hundred-fold of its volume and weight, respectively) while with neglectable size increment (as low as 1%) to target. Moreover, benefitting from peculiarities of online reprogramming and controllable disintegration, the parasitic millirobots can rewrite its locomotion mode according to the task and disintegrate themselves after mission accomplished, offering high adaptivity and compatibility for in vivo biomedical applications. Methods for conversion and fabrication thereof are also provided.

A system for the percutaneous application of a fluid to one or more surface areas of a skin. The system may include at least one of at least one compressor and at least one fan for providing compressed air. The system may also include an applicator fluidically connectable to the at least one of the at least one compressor and the at least one fan. The applicator may have at least one outlet opening through which a fluidic jet is flowable and directable onto the skin. The at least one of the at least one compressor and the at least one fan is attached to the applicator.

The disclosed subject matter relates to a system and method for delivery of therapeutic agents across membranes such as to the inner ear. The system includes a plurality of microneedles that can be delivered to the round window membrane by a delivery device, e.g. catheter, and is capable of controlled penetration of the round window membrane to create temporary and self-closing perforations.

A method and system for combination therapy utilizing local drug delivery and radiotherapy at a target site of body tissue are provided. The delivery system comprises a source electrode adapted to be positioned proximate to a target site of internal body tissue. A counter electrode is in electrical communication with the source electrode, and is configured to cooperate with the source electrode to form a localized electric field proximate to the target site. A cargo may be delivered to the target site when exposed to the localized electric field. Radiotherapy is applied to the target site in combination with the local drug delivery.

This invention relates to a device and method for the vacuum-assisted delivery of drugs through an intact surface membrane of an organ.

Certain substances (e.g., large molecules) that ordinarily cannot traverse the blood brain barrier can be introduced into the brain by applying an alternating electric field to the brain for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the blood brain barrier. In some embodiments, the frequency of the alternating electric field is less than 190 kHz (e.g., 100 kHz). Once the permeability of the blood brain barrier has been increased, the substance is able to cross the blood brain barrier.

The present invention discloses an advance in enhanced stability, enhanced solubility, and enhanced uniqueness towards a micro needling stamper device by proposing an improved process by presenting a technique where skin care products are delivered by way of a needling device is presented. The device has a suction that operates in the casing of the needles. When the stamping of the microneedles occurs, this suction feature lift the skin from it's a regular lying surface. The suction feature promotes blood circulation which will promote cell repair and aide in regeneration. This vacuum like suction separates different layers of tissues, thus microtrauma from the needles is more confined to the layer desired; the epidermis. This also triggers an inflammatory response flooding the area with white blood cells, platelets, and other healing aids for the re-generation process.

A device comprising a housing having a handle end and a treatment end. The treatment end is configured to provide an antimicrobial treatment and a heat treatment. The treatment end comprises an applicator having an applicator surface for providing at least the heat treatment. The device includes a heat generation unit configured to heat the applicator surface in use, a source of antimicrobial agent, and a control unit operatively connected to at least the heat generation unit for controlling the heat generation unit. The device can be a hand-held device and used to apply topical treatment to a treatment area of a subject.

A system and method for providing fluid to a tissue site is described. The method fluidly couples an instillation therapy system to the tissue site and monitors a pressure supplied to the tissue site by a reduced-pressure source with the instillation therapy system for a time period. The method provides fluid to the tissue site with the instillation therapy system in response to the pressure at the tissue site during the time period. The system includes a pressure sensor fluidly coupled to the tissue site to measure a pressure proximate the tissue site. A valve and a flow meter are fluidly between a fluid reservoir and the tissue site. A controller is communicatively coupled to the pressure sensor and the valve and configured to monitor the pressure at the tissue site and a volume of fluid flow to the tissue and, in response, operate the valve.