The present invention relates in a first aspect to an adhesion material for use in an individual containing encapsulated phase-change material. In particular, the adhesion material is for cosmetical or medicinal use in the body of an individual. The adhesion material contains encapsulated phase-change material having preferably a phase transition temperature above 40° C., like above 55° C. The adhesion material is particularly useful for adhering elements, like dental restorations, e.g. crowns or bridge, or brackets on elements in the body of an individual, like teeth or implants. That is, the adhesion material is particularly useful for adhering material in dental applications. In another aspect, a method is provided allowing removing a bracket, a crown or bridge, from implants, abutments or teeth. Furthermore, dental implant restoration systems and kits for permanent fixation of implants allowing improved removal thereof are provided.

Methods and related systems for modulating neural activity by cyclically modulating neural activity in peripheral neural structures are disclosed. Neural activity may be modulated cyclically by stimuli delivered via various types of stimulus sources. In an aspect, activity of a sensory nerve is modulated. Neural modulation may be used, for example, to modulate an undesired sensation, such as pain, or an immune or inflammatory response or process. Delivery of stimuli for modulating neural activity may be controlled in part in response to an input from a user input device.

Methods and kits for treating or preventing an eye condition or for cleaning an eye area tissue are provided. A method of the invention includes administering an isoprenoidal essential oil to eye area tissue, chafing eye area tissue with an abrasive, and removing the abrasive. A kit according to the invention includes an isoprenoidal essential oil, an abrasive for chafing eye area tissue, and in instruction for use for treating an eye condition or cleansing an eye area tissue. The invention also includes a composition of matter comprising an isoprenoidal essential oil and a plurality of abrasive particles in ophthamologically acceptable base.

Systems and methods for skin rejuvenation are disclosed herein. In an embodiment, a skin rejuvenation system includes a unit dose of a booster product that includes active ingredients of ferulic acid and phloretin; a unit dose of at least one exfoliating product that includes active ingredients of ferulic acid and phloretin in combination with fruit acids or alpha hydroxyacids; and a unit dose of a nano-additive product for enhancing penetration of the active ingredients. A method for skin rejuvenation includes applying topically, to a skin surface to be treated, a booster product including active ingredients of ferulic acid and phloretin; applying topically, to the skin surface, at least one exfoliating product including active ingredients of ferulic acid and phloretin in combination with one of fruit acids or alpha hydroxyacids; and applying topically, to the skin surface, a nano-additive product for enhancing penetration of the active ingredients.

A method for delivering matter into a human body is provided via a manual or automatic hand-held delivery device configured to provide a pressurized stream of fluid. The fluid contains compounds, chemicals, nutrients, vitamins or other desired matter. A user, via the device, is configured to target the pressurized stream of fluid to a location on the human body, e.g. the user's skin or mucosa. The pressurized stream is configured to penetrate the user's skin or mucosa such that at least a portion of the fluid is absorbed into the user's skin or mucosa. Various preconditioning methods are provided to increase the absorption rate and bioavailability.

Systems, devices, and methods are described for providing, among other things, improvement in treatment of abnormal tissues including cancer, utilizing light activated drug therapy. Improvements include the use of optical penetration and drug penetration enhancers, in combination with photosensitizing drugs, and the use of localization aids and implements, which enable treatment of larger tissue volumes using minimal tissue access. The cytotoxic photoactivation process is also improved by using internal guidance to direct the light source to and at the lesion site using a naturally occurring orifice or intravascular access route.

Apparatuses and methods for delivering bioactive substances or cosmetic substances using plasmaporation and microneedles are provided. The delivery of the substances includes topical, intracellular, intercellular, and transdermal delivery to the subject.

The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.

The present invention provides compositions, methods and kits for treating skin, which combine administration of glucosamine hydrochloride and red light having a peak wavelength of about 600 nm to about 750 nm, near infrared light having a peak wavelength of about 750 nm to about 1000 nm, or both.

The present disclosure provides a device (30) for delivering a substance to the inner ear. The device (30) comprises a pressure oscillator (32) configured to generate pressurised air at a predetermined oscillation frequency, an aural probe (31) comprising an air passageway extending from a first end of the aural probe (31) to a second end of the aural probe (31), the first end being the end to be inserted into the ear canal, a tube (33) arranged to couple the second end of the aural probe (31) to the pressure oscillator (32), and a pressure relief valve (34) disposed at the tube (33) and/or the aural probe (31) configured to release a portion or the generated pressurised air from within the tube (33) and/or the aural probe (31) when a pressure within the tube (33) and/or the aural probe (31) reaches a predetermined maximum pressure. The present disclosure further provides a method for delivering a substance to the inner ear, the method comprising the steps of: (i) administering the substance to the middle ear; and (ii) generating oscillating air pressure within the ear canal.