Ingestible devices can directly deliver therapeutic agents to desired tissue(s) of the GI tract of a subject, such as the submucosa, the mucosa, and/or the mucus layer of the GI tract, and methods of using the same. The ingestible devices can deliver therapeutic agents in a safe, effective, and reliable manner. The disclosure also provides pharmaceutical compositions for use in methods of treating a disease or condition in a subject in need thereof.

Proposed is a cartridge (1000) for accommodating a microneedle patch (100) comprising: a body portion (1002) which is accommodated in an accommodating part formed in a housing (201) of an applicator (200), and a flat plate portion (1004), mounted on the body portion (1002), comprising a flat plate opening (1006) through which a pressurizing part (404) of a drive mechanism (400) passes and a fixing portion (1005) operatively coupled to the drive mechanism (400), wherein the flat plate portion (1004) is rotated according to a driving of the drive mechanism (400) and is located below the microneedle patch (100) to supports the microneedle patch (100).

The invention discloses a device for collection of tiny charges in the Nano-Coulomb-range and below, comprising at least one capacitor stack build by n capacitors and 2n switches (nϵN), at least one further capacitor outside the capacitor stack as buffer capacity, at least two additional switches and a DC input source. The n capacitors are dedicated to be sequentially charged by the DC input source one after the other, wherein the 2n switches in the capacitor stack couple the n capacitors sequentially to the DC input source. The at least one further capacitor is dedicated to be charged from the n capacitors of the capacitor stack at once. Furthermore, the invention discloses a method for small charge collection, comprising the steps of sequentially charging the n capacitors of the at least one capacitor stack by coupling one capacitor after the other to the DC input source by selectively closing the switches and discharging the n capacitors of the capacitor stack into at least one further capacitor outside the capacitor stack (nϵN). Additionally, the usage of the device or the method according to the invention to collect charges from sources with electrical potentials of a few millivolts is disclosed.

Disclosed herein are methods, devices, and systems for evaluation, diagnosis, prevention, and treatment of peripheral neuropathies.

Provided is a micro-needle array in which all fine needles can be more easily inserted into the skin regardless of positions where the fine needles of the micro-needle array are located on a substrate. The micro-needle array includes: a substrate; and a plurality of micro-needles arranged on one surface of the substrate. Tip parts of the plurality of micro-needles have a height difference, and the micro-needles have a needle length of 80 μm or more and 2000 μm or less. The height difference of the plurality of micro-needles is preferably based on unevenness of the substrate.

Methods, devices and systems for delivery of an anti-PD-1 or an anti-PD-L1 therapeutic agent to the lymphatic system for treating cancer in a patient are described.

Proposed is a cartridge (1000) for accommodating a microneedle patch (100) comprising: a body portion (1002) which is accommodated in an accommodating part formed in a housing (201) of an applicator (200), and a flat plate portion (1004), mounted on the body portion (1002), comprising a flat plate opening (1006) through which a pressurizing part (404) of a drive mechanism (400) passes and a fixing portion (1005) operatively coupled to the drive mechanism (400), wherein the flat plate portion (1004) is rotated according to a driving of the drive mechanism (400) and is located below the microneedle patch (100) to supports the microneedle patch (100).

Disclosed are devices for delivering a rheumatoid arthritis drug across a dermal barrier. The devices include microneedles for penetrating the stratum corneum and also include structures fabricated on a surface of the microneedles to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. The pattern of structures on the surface of the microneedles may include nano-sized structures.

Microstructure arrays and methods for using and manufacturing the arrays are described.

A dermal patch system for administering a pharmaceutical includes a vial that stores a pharmaceutical and a cartridge coupled to the vial. The cartridge includes a pull mechanism, a pump, a plurality of microneedles in communication with the vial. The microneedles are configured to move between an undeployed position to a deployed position. When pulled, the pull mechanism is configured to cause the microneedles to move from the undeployed position to the deployed position and cause the pump to pump the pharmaceutical from the vial and to the microneedles.