The present invention provides a microneedle array, a support member, a method of producing a microneedle array, and a microneedle array unit which enable reduction of a drying time during production and prevention of breakage during drying. Provided are a microneedle array 120 including a sheet portion 41, a plurality of needle-like protrusions 44, and a support member 50 formed of a gripping portion 52 and a beam portion 54 having one end that is connected to the gripping portion 52, in which the sheet portion 41 is an integrally molded body which is integrally molded with the support member 50, in which at least a part of the beam portion 54 is buried under the other surface 43 of the sheet portion 41, opposite to the one surface where the needle-like protrusions 44 are provided, the gripping portion 52 is provided on the other surface 43 of the sheet portion 41, and the beam portion 54 is deformable toward a center of the sheet portion 41. Further, provided are the support member 50, a method of producing the microneedle array 120, and a microneedle array unit 300 including a container 310.

A reusable applicator for applying a microneedle patch to a skin of a subject which comprises a base for positioning onto the skin. The base comprises a skin-side end and a holder for holding the microneedle patch in position relative to the skin-side end. Two or more contact parts at the skin-side end can contact the skin. One or more are movable over the skin and away from the other contact 5 parts to stretch the skin at least during penetration of the skin by a microneedle of the patch. The applicator further comprises an interface for an actuator. The actuator actuates in operation a movement of the microneedle patch relative to the skin-side end to penetrate at least into the stratum corneum of the epidermis of the skin with the microneedle. A microneedle patch comprises a skin-adhesive surface for attaching the patch to the skin of a10 subject. The patch has one or more microneedles projecting from the skin-adhesive surface out of the patch. A stiffening body stiffens the patch in at least a parallel direction parallel to the skin-adhesive surface in a region of the skin-adhesive surface which includes the microneedle.

Transdermal drug delivery devices are described herein such as a microneedle array patch, to be placed on the skin for transdermal delivery of a medicament. The transdermal drug delivery device for delivery of a bioactive agent through mammalian skin comprises an array of microneedles and a means to actuate the microneedles, wherein the actuation means actuates the microneedles separately.

A microneedle applicator is provided. A microneedle applicator according to an embodiment of the present invention comprises: a microneedle array; an operation member disposed on the upper portion of the microneedle array and operating such that a user applies an external force so as to insert a microneedle into skin; a housing for accommodating the microneedle array and the operation member; a first guide member disposed in at least one position on a lateral portion of the operation member or on a lateral portion of an interworking member of the operation member; and a second guide member which is disposed on the inner surface of the housing in a position corresponding to the first guide member so as to be engaged with the first guide member, and allows the first guide member to slide so as to prevent the microneedle array from rotating or horizontally distorting when the microneedle array uniformly vertically descends due to the external force.

According to some embodiments, a syringe may include a barrel; a delivery conduit; a plunger seal disposed within the barrel; and a plunger rod assembly affixed to an end of the barrel, the plunger rod assembly including a first plunger rod component comprising a first linear gear, a second plunger rod component disposed at least partially in the barrel and engaged with the plunger seal, wherein the second plunger rod component comprises a second linear gear, a first rotational gear having a plurality of gear teeth for engaging the first linear gear, and a second rotational gear having a second plurality of gear teeth for engaging the second linear gear, wherein the first rotational gear is coupled to the second rotational gear such that translation of the first plunger rod component causes translation of the second plunger rod component.

A sensor includes a working electrode in contact with an analyte solution; an amplifier including: a source terminal; a drain terminal; a back gate terminal; and nanowires, each nanowire electrically connecting the source terminal to the drain terminal; and an insulator having a first side and a second side. The working electrode is positioned to the first side of the insulator. The source terminal, the drain terminal, and the nanowires are positioned to the second side of the insulator. The insulator prevents direct electrical contact between the working electrode, the analyte solution and either the source terminal, the drain terminal, or the nanowires. The working electrode is configured such that, when a chemical species is present in the analyte solution, a variation in an electrical field at a location of the nanowires is induced, inducing a corresponding variation in an electrical current between the source terminal and the drain terminal.

An applicator for inserting a micro needle array (4) into skin includes a holding part (211) that holds the micro needle array (4), and an insertion assist part (223) that forms an insertion complete state in which a central array region of the micro needle array (4) further protrudes on the skin side than a peripheral array region provided closer to a peripheral side of the micro needle array (4) than the central array region.

An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.

The present invention relates to a kit comprising: at least one microneedle sheet (1) comprising a substrate layer and a plurality of microneedles on the substrate layer, the microneedles comprising at least one water-soluble or water-dispersible polymer; and a device comprising an applicator (2-3) comprising an application surface, a container (2-1) comprising a cosmetic composition and a valve, wherein the microneedle sheet (1) is capable being attached to the applicator (2-3) by attaching the substrate layer of the microneedle sheet to the application surface, the applicator (2-3), the container (2-1) and the valve are configured to supply the cosmetic composition via the valve onto the microneedle sheet (1). The kit according to the present invention can prevent the repeated use of microneedles (1), and can apply a cosmetic product in an easy and sanitary manner.

A fluid delivery apparatus includes a collet assembly having an upper and lower wall attached at a central portion of the collet. The central portion defines an inner step, and the lower wall includes circumferentially-spaced flexible tabs. The fluid delivery apparatus also includes a fluid distribution assembly coupled to the collet assembly. The fluid distribution assembly is positionable relative to the collet between a pre-use configuration and a pre-activated configuration. The fluid distribution assembly has a plenum that includes a sleeve component having an exterior ledge extending thereabout. A lower wall portion of the sleeve component includes protrusions corresponding to the flexible tabs of the collet. In the pre-use configuration the exterior ledge of the sleeve component is engaged with the inner step of the collet assembly, and each flexible tab engages a respective protrusion to provide a snap-fit between the fluid distribution assembly and the collet assembly.