A magazine for accommodating pellets for use in an injector includes a barrel comprising a hollow cylindrical compartment with an open front end and an open rear end. The cross-section of the compartment is selected to accommodate a pellet. The cross section of the rear end is smaller than the accommodated pellet so that it cannot be extracted from the rear end of the compartment. The magazine further includes a cover for closing the front end, including a dispensing opening which, in the closed state, is positioned in front of the front end and has a cross-section selected such that the pellet can pass through the dispensing opening. At least one bar projecting into the dispensing opening prevents the pellet from accidentally falling out, and when subjected to a predetermined force, can be bent outwards such that the pellet can be delivered through the dispensing opening.

Components with relatively high loading of active pharmaceutical ingredients (e.g., drugs), are generally provided. In some embodiments, the component (e.g., a tissue interfacing component) comprises a solid therapeutic agent (e.g., a solid API) and a supporting material (e.g., a binder such as a polymer) such that the solid therapeutic agent is present in the component in an amount of greater than or equal to 10 wt % versus the total weight of the tissue interfacing component. Such tissue-interfacing components may be useful for delivery of API doses e.g., to a subject. Advantageously, in some embodiments, the reduction of volume required to deliver the required API dose as compared to a liquid formulation permits the creation of solid needle delivery systems for a wide variety of drugs in a variety of places/tissues (e.g., tongue, GI mucosal tissue, skin) and/or reduces and/or eliminates the application of an external force in order to inject a drug solution through the small opening in the needle. In some cases, a physiologically relevant dose may be present in a single tissue interfacing component (e.g., having a relatively high API loading).

Self-actuating articles including, for example, self-actuating needles and/or self-actuating biopsy punches, are generally provided. Advantageously, the self-actuating articles described herein may be useful as a general platform for delivery of a wide variety of pharmaceutical drugs that are typically delivered via injection directly into tissue due to degradation in the GI tract. The self-actuating articles described herein may also be used to deliver sensors and/or take biopsies without the need for an endoscopy. In some embodiments, the article comprises a spring (e.g., a coil spring, a beam, a material having particular mechanical recovery characteristics). Those of ordinary skill in the art would understand that the term spring is not intended to be limited to coil springs, but generally encompass any reversibly compressive material and/or component which, after releasing an applied compressive force on the material/component, the material/component substantially returns to an uncompressed length of the material/component (e.g., the within 95% of the length of the material/component prior to compression).

An injector system (500) for injection by puncture of an organ, of a non-deformable medical implant (200) into a subject comprising: a holding element (100) having a proximal (10) and distal (20) end disposed with a chamber (102) for containing the implant (200), wherein the holding element (100) is disposed with an exit port (104) at the distal end (20) for slidable ejection of the implant (200) therethrough and into a bore (404) of a needle component (402) of an injection needle assembly (400), a compliant member assembly (150) having a through-passage (154), comprising at least two compliant members (152), the compliant member assembly (150) having a biased state in which the at least two compliant members (152) additively form a partial or total occlusion of the through-passage (154), wherein: the compliant member assembly (150) is configured in the biased state as a mechanical stop adapted to stop slidable entry of the implant (200) into the bore (404) under a force of gravity, the through-passage (154) is configured to receive slidably the implant under a force of injection in which the at least two compliant members (152) deform and frictionally engage the implant (200), the complaint member assembly (150) is configured to align the implant with the bore of the needle component.

An implantable drug delivery device and method for delivering a drug to a living body. The device includes a housing having at least one opening, a reservoir within the housing adapted to contain a drug, a temporary seal closing the opening of the housing, and a heating element in thermal contact with the temporary seal. The heating element is adapted to generate heat in response to a magnetic field to melt the temporary seal and release a drug within the reservoir through the opening of the housing.

A radio frequency identification (RFID) tag insertion cartridge configured for use in implanting a flexible RFID tag into a small animal using a needle-retraction implant tool. In embodiments, the cartridge includes a cartridge housing and a bevel cap. In embodiments, the cartridge housing is configured to receive a carriage portion inserted into a first end of the cartridge housing with a retractable needle extended out of a second end of the carriage portion to present the retractable needle in an extended position with the RFID tag carried within the retractable needle. In embodiments, the bevel cap has a proximal portion with a mating feature configured to mate with the cartridge housing and one or more needle capture elements configured to selectively couple to the needle in the extended position in a side-mountable manner without a direct axial force being exerted on the needle.

A safety housing based implant/medicament injecting system. System includes a needle assembly prefilled implant/medicament for injection and an injecting needle/cannula, a housing for accommodating the needle assembly under usual bias inside said housing, a plunger means having a plunger rod configured for stage wise forward motion including an initial injecting plunger forward motion with the needle assembly within the housing to first engage the needle assembly with the housing and subsequent continuing injecting plunger forward motion independent of the needle assembly for injecting of the implant/medicament, and post injecting return of the needle assembly secured inside said housing blocking any subsequent use thereof.

A device for delivering a drug depot into a patient via a cannula is provided. The device includes a housing with a coupling mechanism. A drug cartridge is positioned within the housing and includes a cartridge depot channel having an occluding device that includes a ramp and a plateau. The occluding device occludes the cartridge depot channel to prevent the drug depot from moving beyond the occluding device without force applied to the drug depot sufficient to deflect the occluding device an amount to allow the drug depot to move beyond the occluding device. The drug cartridge includes an alignment boss with an end channel coaxial with the cartridge depot channel. A push rod is slidably receivable in the housing and the drug cartridge to move the drug depot beyond the occluding device, into the cartridge depot channel, through the cannula and into the patient.

A surgically implantable reservoir is provided for implantation into a patient for use in an iontophoresis system for local drug delivery through a target site of internal body tissue. The reservoir comprises a housing having an inner surface defining an enclosed chamber and an inlet opening and an outlet opening for flow of fluid including the drug through the chamber. The housing is capable of interacting with a localized electric field to release the drug. A platform holding an electrode extends inwardly into the chamber from the inner surface of the housing such that the platform and an adjacent portion of the inner surface of the housing define a trough surrounding the platform. Fluid flow through the reservoir from the inlet opening to the outlet opening moves gas bubbles formed by electrolysis from the surface of the electrode and carries the bubbles through the outlet opening.

Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).