A method of atraumatic medication pellet delivery using an atraumatic trocar apparatus is described. The atraumatic trocar apparatus includes a cannula and an obturator. The method includes receiving the obturator by the cannula, wherein the obturator passes through the interior passage and exits through the anterior cannula opening so that the obturator anterior rounded tip extends past the anterior cannula end and at least one opening proximate to the anterior rounded tip also extends past the anterior cannula end. The method includes inserting the atraumatic trocar through an incision into subcutaneous tissue along an insertion path to an insertion length. Additionally, the method includes inserting one or more medication pellet into the medication slot of the inserted cannula and delivering the medication pellet(s) through the interior passage of the cannula to a subcutaneous delivery site by inserting the obturator into the posterior opening of the cannula.

A circular stapling device includes one or more therapeutic-containing suppositories that may be secured to an anastomotic site during an anastomotic procedure to reduce the level of bacterial collagenase and minimize the likelihood of anastomotic leakage.

Various disclosed embodiments include illustrative apparatuses, systems, and methods for injecting medicant into target tissue. In an illustrative embodiment, an illustrative apparatus includes a distal end, a proximal end configured to engage a delivery catheter, and a plurality of flexible bands that extend from the distal end to the proximal end. The flexible bands exhibit a delivery configuration and a deployed expanded configuration. When the plurality of flexible bands are in the deployed expanded configuration a cavity is formed and a medicant receivable via the delivery catheter is disbursable into the cavity.

A safety housing based implant/medicament injecting system. System includes a needle assembly prefilled implant/medicament for injection and an injecting needle/cannula, a housing for accommodating the needle assembly under usual bias inside said housing, a plunger means having a plunger rod configured for stage wise forward motion including an initial injecting plunger forward motion with the needle assembly within the housing to first engage the needle assembly with the housing and subsequent continuing injecting plunger forward motion independent of the needle assembly for injecting of the implant/medicament, and post injecting return of the needle assembly secured inside said housing blocking any subsequent use thereof.

Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

Embodiments herein describe tools, instruments and methods for aseptic loading, dispensing and/or delivering cells into an implantable device and aseptically and selectively sealing a device inside a sterile package as well as and storing and preparing for shipment the cell-filled device.

A safety housing based implant/medicament injecting system. System includes a needle assembly prefilled implant/medicament for injection and an injecting needle/cannula, a housing for accommodating the needle assembly under usual bias inside said housing, a plunger means having a plunger rod configured for stage wise forward motion including an initial injecting plunger forward motion with the needle assembly within the housing to first engage the needle assembly with the housing and subsequent continuing injecting plunger forward motion independent of the needle assembly for injecting of the implant/medicament, and post injecting return of the needle assembly secured inside said housing blocking any subsequent use thereof.

Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include a housing having a proximal portion including a proximal opening, distal portion including a distal opening, and an intermediate portion sized to contain a medical device; and an inserter having at least a portion comprising a greater width than at least one other portion of the inserter.

A medical delivery device suitable for insertion into a lumen of a patient, the medical device (100, 200) comprising a capsule (110, 120, 210, 220) sized to be inserted into the lumen, the capsule comprising a base member, and an actuation mechanism comprising an actuation member (150, 250, 350) configured for movement relative to the base member along an axis, and an energy source (140, 240, 340) associated with the actuation member for powering the actuation member to move relative to the base member along the axis. The base member and the actuation member define a latch assembly comprising: a) a dissolvable firing member (160, 260, 360), the dissolvable firing member being at least partially dissolvable when subjected to a biological fluid, b) a retainer portion (113, 213, 313) comprised by one of the base member and the actuation member, and c) a movable latch (152, 252, 352) configured for lateral movement relative to the axis, the movable latch defining a first surface with a blocking portion (153, 253, 353), and a second surface (152a, 252a, 352a) configured for interacting with the dissolvable firing member (160, 260, 360). In a pre-firing configuration, the blocking portion (153, 253, 353) of the movable latch engages the retainer portion (113, 213, 313) in a latching engagement, and the second surface (152a, 252a, 352a) of the movable latch interacts with the dissolvable firing member to restrict lateral movement of the movable latch thereby preventing release of the latching engagement. In a firing configuration where the dissolvable firing member (160, 260) has become at least partially dissolved, the movable latch is allowed to move laterally thereby releasing the latching engagement.