Various embodiments are disclosed herein related to fluidic connections for modules useable in combinatorial drug delivery devices. The fluidic connections allow for variable flow paths to be defined for serially-connected, and base-tray mounted, modules.

Infusion systems and methods for administering an infusion fluid into a patients anatomic space at a variable flow rate without flow control include an administration set having a flexible tube fluidically connected to a needle connector, the needle connector including a receiving end fluidically connected to flexible tube, and an administering end opposite the receiving end and fluidically connected with an infusion needle, and the infusion needle having an inside diameter of about 0.0104 inches to about 0.0135 inches and fluidically connected to the administering end of the flexible tubing to deliver the infusion fluid to the patients anatomic space at variable flow rates dependent upon the saturation of the infusion fluid at the patients injection site.

Sorbent cartridges having a flow control insert to improve the functional capacity of a sorbent cartridge is provided. Flow control inserts can include a plurality of flow channels filled with sorbent material through which fluid to be regenerated can travel in the sorbent cartridge.

Sorbent cartridges having a flow control insert to improve the functional capacity of a sorbent cartridge is provided. Flow control inserts can include a plurality of flow channels filled with sorbent material through which fluid to be regenerated can travel in the sorbent cartridge.

Inline pumps with rear attachable syringes include a pump and a syringe with each designed so that the pump syringe system may be easily coupled and decoupled in the field. An end mount block on the pump has a slot shaped to accept a similarly shaped plunger button and plunger rod on the syringe. A user aligns the plunger button of the syringe next to the slot on the mount block of the pump, and slides the plunger button and rod into the inner cavity of the pump. Both the pump and the syringe have threaded couplers which securely couple the pump to the syringe by rotating the couplers with respect to each other.

Some fluid coupling devices described herein are configured for use in fluid systems for purposes of providing a repeatable, aseptic fluid coupling system. Such repeatable, aseptic fluid coupling systems are configured to facilitate multiple connection and disconnection cycles while repeatably establishing a sterile fluid pathway through the coupling system. The repeatable, aseptic fluid coupling systems can repeatably establish a sterile fluid pathway through the coupling system even though the coupling system may be used in a non-sterile environment.

A frangible connector has a first side that forms a female luer when a second side is fractured at a predefined break line. The second side may be connected to a fluid circuit, for example, a source of medical treatment fluid such as dialysate.

A frangible connector has a first side that forms a female luer when a second side is fractured at a predefined break line. The second side may be connected to a fluid circuit, for example, a source of medical treatment fluid such as dialysate.

A tubular coupling comprising a first connector comprising a body defining a first passageway portion and a valve area, the valve area comprising a first volume adjacent to an end of the first passageway portion; and a second volume in fluid communication with the first volume; and a first valve disposed in the first volume of the valve area; and a second connector adapted to receive at least a portion of the first connector, the second connector comprising: a body defining a second passageway portion and a valve area, the valve area comprising: a first volume adjacent to an end of the second passageway portion; and a second volume in fluid communication with the first volume; and a second valve disposed in the first volume of the valve area.

A tubular coupling comprising a first connector comprising a body defining a first passageway portion and a valve area, the valve area comprising a first volume adjacent to an end of the first passageway portion; and a second volume in fluid communication with the first volume; and a first valve disposed in the first volume of the valve area; and a second connector adapted to receive at least a portion of the first connector, the second connector comprising: a body defining a second passageway portion and a valve area, the valve area comprising: a first volume adjacent to an end of the second passageway portion; and a second volume in fluid communication with the first volume; and a second valve disposed in the first volume of the valve area.