The volume of a hyperinflated lung compartment is reduced by sealing a distal end of the catheter in an airway feeding the lung compartment. Air passes out of the lung compartment through a passage in the catheter while the patient exhales. A one-way flow element associated with the catheter prevents air from re-entering the lung compartment as the patient inhales. Over time, the pressure of regions surrounding the lung compartment cause it to collapse as the volume of air diminishes. Residual volume reduction effectively results in functional lung volume expansion. Optionally, the lung compartment may be sealed in order to permanently prevent air from re-entering the lung compartment.

Methods of manufacturing tissue interfacing components, such as solid needles comprising one or more therapeutic agents, are disclosed. In some embodiments, a method for manufacturing a tissue interfacing component comprises compressing a granular therapeutic agent within a mold cavity of a mold to form a solid tissue interfacing component. The mold cavity may define an elongated shape extending along a longitudinal axis from an opening of the mold cavity to a distal end of the mold cavity, and the granular therapeutic agent may be compressed by moving a mold punch along the longitudinal axis towards the distal end. After compressing the granular therapeutic agent to form the solid tissue interfacing component, the tissue interfacing component may be removed from the mold and subsequently inserted into tissue to deliver the therapeutic agent to a subject.

A patient interface may include a dual chamber cushion assembly having a nasal chamber and an oral chamber. The nasal chamber may be arranged to deliver pressurized breathable gas to a patients nasal passages, and the oral chamber may be arranged to deliver pressurized breathable gas to the patients oral passages. The nasal chamber may be pressurized to a different level than an oral chamber to promote nasal breathing. An air passage may fluidly connect the nasal chamber and the oral chamber so that pressurized breathable gas may flow from the nasal chamber to the oral chamber.

A patient interface may include a dual chamber cushion assembly having a nasal chamber and an oral chamber. The nasal chamber may be arranged to deliver pressurized breathable gas to a patients nasal passages, and the oral chamber may be arranged to deliver pressurized breathable gas to the patients oral passages. The nasal chamber may be pressurized to a different level than an oral chamber to promote nasal breathing. An air passage may fluidly connect the nasal chamber and the oral chamber so that pressurized breathable gas may flow from the nasal chamber to the oral chamber.

A system for delivering a composition containing a nutritional supplement matrix to a user through the oral mucosa, in which the matrix is held under pressure in a canister that has a nozzle with at least one rotating internal member positioned between the canister outlet and the nozzle outlet, in which the rotating member agitates the composition to increase atomization to aid in absorption.

A system for delivering a composition containing a nutritional supplement matrix to a user through the oral mucosa, in which the matrix is held under pressure in a canister that has a nozzle with at least one rotating internal member positioned between the canister outlet and the nozzle outlet, in which the rotating member agitates the composition to increase atomization to aid in absorption.

A water bottle with a pressurized compartment and an unpressurized compartment to integrate supplemental oxygen delivery into a hydration and electrolyte management system. The unpressurized compartment may be manually filled with a fluid. The user may consume fluid from the unpressurized compartment and an aerosol from the pressurized compartment independently or simultaneously.

A water bottle with a pressurized compartment and an unpressurized compartment to integrate supplemental oxygen delivery into a hydration and electrolyte management system. The unpressurized compartment may be manually filled with a fluid. The user may consume fluid from the unpressurized compartment and an aerosol from the pressurized compartment independently or simultaneously.

The present invention provides a system, a kit and a use thereof for oral mucosa delivery of a composition. The composition may comprise at least two sub-compositions admixed right before dispensing to the oral mucosa. In one embodiment, the system is a pressurized system. In another embodiment, the admixed sub-compositions are atomized. In one embodiment, one of the sub-compositions comprise a beneficiary gas, such as oxygen. In another embodiment, one of the sub-compositions comprise a nutritional supplement, a nutraceutical composition, a pharmaceutical composition, or any combinations thereof.

The present invention provides a system, a kit and a use thereof for oral mucosa delivery of a composition. The composition may comprise at least two sub-compositions admixed right before dispensing to the oral mucosa. In one embodiment, the system is a pressurized system. In another embodiment, the admixed sub-compositions are atomized. In one embodiment, one of the sub-compositions comprise a beneficiary gas, such as oxygen. In another embodiment, one of the sub-compositions comprise a nutritional supplement, a nutraceutical composition, a pharmaceutical composition, or any combinations thereof.