A flexible body comprises a polymer film having a first surface and an opposing second surface. The polymer film has a plurality of apertures extending from the first surface to the second surface and a plurality of raised lips protruding from the first surface such that each of the plurality of apertures is surrounded by one of the plurality of raised lips. A method of producing a polymer film comprises placing a polymer solution into a one sided mold having a plurality of protrusions extending from a bottom of the mold wherein the polymer solution is characterized by a viscosity that inhibits the unaided flow of the polymer throughout the mold; urging the polymer solution around each of the plurality of protrusions; and solidifying the polymer solution.

Provided is a downhole tool member containing a polyglycolic acid resin composition that is easy to process during extrusion molding or injection molding, is able to reduce cracks during cutting and transportation, and has sufficient strength in a well in a high temperature environment. The downhole tool member according to an embodiment of the present invention contains a polyglycolic acid resin composition, in which a weight-average molecular weight Mw is from 150,000 to 300,000, and a melt viscosity My (Pa.Math.s), measured at a temperature of 270 C. under a shearing speed of 122 sec.sup.1, satisfies Mv<6.210.sup.15Mw.sup.3.2.

The present invention is directed to bioresorbable polymers to be used as bone and tissue adhesives. The present invention is also directed to the synthesis of bioresorbable polymeric molecules bearing adhesive moieties and the use of such compounds in methods to glue and stabilize fractured bones and damaged tissues. The present invention is also directed to the use of such compounds as adhesive sealants for applications in wound care. The present invention is also directed to the use of such compounds as biodegradable ink for applications in tissue engineering and 3D printing. The present invention also relates to the use of such compounds as drug delivery platforms.

A medical device includes a balloon expanded scaffold crimped to a catheter having a balloon. The scaffold has a network of rings formed by struts connected at crowns and links connecting adjacent rings. The scaffold is crimped to the balloon by a process that includes using protective polymer sheaths or sheets during crimping, and adjusting the sheaths or sheets during the crimping to avoid or minimize interference between the polymer material and scaffold struts as the scaffold is reduced in size.

A medical device includes a balloon expanded scaffold crimped to a catheter having a balloon. The scaffold has a network of rings formed by struts connected at crowns and links connecting adjacent rings. The scaffold is crimped to the balloon by a process that includes using protective polymer sheaths or sheets during crimping, and adjusting the sheaths or sheets during the crimping to avoid or minimize interference between the polymer material and scaffold struts as the scaffold is reduced in size.

A method for manufacturing a microprojection unit (10) according to the invention involves: a microprojection tool forming step of forming a microprojection tool (1) by bringing a projecting mold part (11) into contact from one surface (2D) side of a base sheet (2A) including a thermoplastic resin, and thus forming a protrusion (3) that protrudes from another surface (2U) side, and withdrawing the projecting mold part (11) from the interior of the protrusion (3); a joining step of joining the one surface (2D) side of the base sheet (2A), in which the microprojection tool (1) has been formed, and a tip end of a base component (4); and a cutting step of cutting the base sheet (2A), to which the base component (4) has been joined, along a contour (4L) of the base component (4) at a position more inward than the base component's contour (4L) in a planar view of the base sheet (2A) as viewed from the microprojection tool (1) side, to manufacture a microprojection unit (10).

A method for manufacturing a microprojection unit (10) according to the invention involves: a microprojection tool forming step of forming a microprojection tool (1) by bringing a projecting mold part (11) into contact from one surface (2D) side of a base sheet (2A) including a thermoplastic resin, and thus forming a protrusion (3) that protrudes from another surface (2U) side, and withdrawing the projecting mold part (11) from the interior of the protrusion (3); a joining step of joining the one surface (2D) side of the base sheet (2A), in which the microprojection tool (1) has been formed, and a tip end of a base component (4); and a cutting step of cutting the base sheet (2A), to which the base component (4) has been joined, along a contour (4L) of the base component (4) at a position more inward than the base component's contour (4L) in a planar view of the base sheet (2A) as viewed from the microprojection tool (1) side, to manufacture a microprojection unit (10).

A flexible body comprises a polymer film having a first surface and an opposing second surface. The polymer film has a plurality of apertures extending from the first surface to the second surface and a plurality of raised lips protruding from the first surface such that each of the plurality of apertures is surrounded by one of the plurality of raised lips. A method of producing a polymer film comprises placing a polymer solution into a one sided mold having a plurality of protrusions extending from a bottom of the mold wherein the polymer solution is characterized by a viscosity that inhibits the unaided flow of the polymer throughout the mold; urging the polymer solution around each of the plurality of protrusions; and solidifying the polymer solution.

Provided are a microneedle with excellent performance and a method for manufacturing the microneedle. A microneedle array in which a polyglycolic acid is used as a material, crystallinity of the polyglycolic acid is 21% or more and axial contraction rate of tips is 99% or more, and a manufacturing method in which a polyglycolic acid are injection-molded at a cylinder temperature of 230-280 C., a metal mold temperature of 60-130 C., and an injection pressure of 1000-1500 KPa so as to manufacture a microneedle array in which crystallinity of the polyglycolic acid is 21% or more and an axial contraction rate of tips is 99% or more.

Disclosed are a biodegradable high-barrier packaging film, a preparation method and an application thereof, belonging to the technical field of biodegradable packaging film processing. The biodegradable high-barrier packaging film includes 60-70 parts of polyglycolic acid (PGA), 40-30 parts of poly(butylene succinate-co-butylene adipate) (PBSA), and 0.1-0.7 part of ADR 4468 (copolymer of styrene, acrylate and glycidyl acrylate), where a sum of the PGA and the PBSA is 100 parts. The preparation method of the biodegradable high-barrier packaging film includes: mixing the PGA, the PBSA and ADR 4468 (copolymer of styrene, acrylate and glycidyl acrylate), and performing melting, extruding and granulating to obtain a blends masterbatch; then extrusion blowing the blends masterbatch into a film to obtain the biodegradable high-barrier packaging film.