A system for preparing a cancer vaccine (and optionally purifying the blood) has a blood filtration system, controlled by a processing unit, for filtering exogenous blood plasma to isolate tumor cells, tumor stem cells and tumor breakdown products. The blood filtration system filter includes multiple layers having differently sized apertures to retain differently sized materials (from among (i) tumor cells of different sizes, (ii) tumor stem cells and (iii) tumor DNA or other breakdown products. A device directs electromagnetic radiation at the isolated tumor cells, tumor stem cells and tumor DNA (or other breakdown products). The electromagnetic radiation may cause at least one of the (i) isolated tumor cells, (ii) isolated tumor stem cells, (iii) isolated tumor protein or breakdown products of the cells such as DNA to have a coagulated outer layer or a coagulated outer surface. The electromagnetic radiation may have a UV wavelength. A conical coil improves blood flow rate uniformity.

Disclosed is a method for treating a renal condition by loco-regional perfusion of one or both of a patient's kidneys (1810). A closed circuit may be formed with a perfusion catheter (1822) positioned in the renal artery of the kidney, a recovery catheter (1824) positioned in the renal vein of the kidney, and an external membrane oxygenator (1820) disposed therebetween. A perfusate containing, for example, a drug may be circulated through the closed circuit while isolating the closed circuit from the patient's systemic circulation.

A cannula for conveying body fluids includes a body extending in an axial direction from a proximal end to a distal end. The body defines a continuous inner cavity and includes at least two rows of holes in the distal region of the body, which are axially spaced apart from each other and each include at least two holes. The holes open in each row of holes from the inner cavity in the radial direction and are circumferentially spaced apart. A row of holes X is arranged distally to at least one further row of holes and a ratio of a total opening area of the holes of the row of holes X to the total opening area of the holes of the at least one further row of holes arranged in proximal direction to the row of holes X is 2:1 to 3:1.

An extracorporeal blood disinfection system (10) includes an input tube (12) forming a flowpath (22) for infected blood from a mammalian patient (11); a disinfection unit (14) including a microbicidal light emitting device (24) emitting a plurality of light emissions, each light emission having a wavelength in a range between about 380 to about 800 nm; a treatment flowpath (22) in communication with the input tube (12) that is substantially transparent to emitted light of the microbicidal light emitting device (24) for receiving at least a portion of the infected blood flow therethrough, wherein the microbicidal light emitting device (24) effectuates a dose of light emissions to the infected blood in the treatment flowpath (22) to disinfect the blood; and an output tube (16) fluidly and physically connected wherein material can flow within the treatment flowpath forming a flowpath the disinfected blood flow from the disinfection unit to the patient.

The oxygenator (10) of organic fluids comprises a container body (20); a first aperture (21) for the entry of oxygen and a second aperture (22) for the exit of an exhausted gas; a third aperture (23) for the entry of an organic fluid to be oxygenated and a fourth aperture (24) for the exit of an oxygenated organic fluid; an oxygenation chamber (30) to oxygenate the organic fluid to be oxygenated, defined inside the container body (20); and a mass (31) of capillary fibers (32) which are impermeable to liquids and porous to gases, disposed so as to be lapped by the organic fluid inside the oxygenation chamber (30), parallel to each other in a first direction (X).

A ventilation system for artificial ventilation of a patient (Pt) includes an inspiratory fluid guide unit (30) that connects a ventilator (1) to a patient-side coupling unit (9). A control unit (4) determines a measure for a net inspiratory volume flow which the ventilator (1) generates and which flows through the inspiratory fluid guide unit (30). Depending on the net inspiratory volume flow, the control unit (4) controls an inspiratory display element (40) on the inspiratory fluid guide unit (30). The actuated inspiratory display element (40) displays two indicators in a visually perceptible manner, namely an indicator for the determined net inspiratory volume flow and an indicator for the direction of flow through the inspiratory fluid guide unit (30).

A ventilation system for artificial ventilation of a patient (Pt) includes an inspiratory fluid guide unit (30) that connects a ventilator (1) to a patient-side coupling unit (9). A control unit (4) determines a measure for a net inspiratory volume flow which the ventilator (1) generates and which flows through the inspiratory fluid guide unit (30). Depending on the net inspiratory volume flow, the control unit (4) controls an inspiratory display element (40) on the inspiratory fluid guide unit (30). The actuated inspiratory display element (40) displays two indicators in a visually perceptible manner, namely an indicator for the determined net inspiratory volume flow and an indicator for the direction of flow through the inspiratory fluid guide unit (30).

Embodiments presented herein relate to various polymers. Some of the polymer embodiments are heparin binding polymers. Some embodiments of the heparin binding polymers can be employed to bind to heparin for methods such as separating, purifying, removing, and/or isolating heparin and heparin like molecules.

Disclosed is a method for treating of Cockayne Syndrome (CS). Specifically, the invention pertains to a method for the extracorporeal treatment of a body fluid by removing the body fluid from a living body diseased with CS, and applying a targeted antibody conjugated to a moiety to at least one Cockayne Syndrome antigen in the body fluid, creating an antibody-antigen moiety complex, removing antibody-antigen moiety complex from the body fluid, and returning the purified body fluid to the body.

A subcutaneous tunneling device includes a shaft having a bend, a catheter connector extending from a distal end of the shaft distal of the bend, and a sleeve. The catheter connector can include a body having a gripping portion, and a barbed extension distal of the body configured for insertion into a lumen of a catheter. The sleeve is slidably mounted on the shaft, and has a retracted position exposing the catheter connector to permit a distal end of a catheter to be coupled thereto, and an extended position covering the catheter connector and the distal end of the catheter.