An apparatus for extracorporeal blood treatment is configured for detecting a disconnection between a connector (6a, 7a) for connection to a vascular access device (400) fixed to a patient (P) and the vascular access device (400) by: calculating a hydrostatic pressure difference (P.sub.H_patient) due to a difference in height between the vascular access device (400) and a pressure sensor (25, 26); calculating a section pressure drop (P.sub.line) due to a section of the blood circuit from the connector (6a, 7a) to the pressure sensor (25, 26); calculating a disconnection pressure (P.sub.disc) from the hydrostatic pressure difference (P.sub.H_patient) and the section pressure drop (P.sub.line); receiving a measured pressure (P) from the pressure sensor (25, 26); detecting a disconnection of the connector (6a, 7a) from the vascular access device (400) by comparing the measured pressure (P) with a pressure alarm threshold (P.sub.thresh) function of the disconnection pressure (P.sub.disc).

A method for treating sickle cell disease comprises removing blood from a patient with sickle cell disease, treating the removed blood to decrease the fraction of sickle-prone cells in the removed blood, and reintroducing the treated blood back into the patient. The treated blood that is reintroduced back into the patient has a reduced number of sickle-prone red blood cells when compared to the blood removed from the patient. In one version, the treatment of the blood includes inducing sickling of the red blood cells prone to sickle and then separating those sickled red blood cells from the blood before reintroducing the blood back into the patient.

A sensor system for measuring oxygen saturation in blood flowing within a neonatal extracorporeal support system (NESS) includes a light source configured to emit a light wave, a light sensor configured to sense a light wave, a control unit, and an alarm. The control unit includes a processor operably coupled to at least one memory having instructions stored therein that, upon execution by the control unit, cause the sensor system to perform operations including emitting at least one light wave from the light source onto blood flowing within the NESS, receiving a reflected light wave from the light source onto blood flowing within the NESS, and comparing a parameter of the reflected light wave to a parameter of the at least one light wave to determine the oxygen saturation in the blood of the NESS. The blood flowing within the NESS is unaltered by the sensor system.

This invention is directed to a novel blood-gas exchange device comprising a stationary blood collecting tank, and a rotating tank, such that the stationary blood collecting tank surrounds at least part of a rotating tank. The circular movement of the rotating tank channels the inserted blood to flow along the rotatable tank wall from bottom to top, forming a blood layer on the wall that directly contacts with the gas and allows gas exchange, and wherein the stationary blood collecting tank is assembled with the rotating tank in a manner that the oxygenated and/or decarbonated blood that exit from the rotating tank through said at least one exit opening is being spilled into the stationary collecting tank and gathered to flow into a tube.

A system and method to deliver a medicant to a premature fetus in an extracorporeal environment. Exemplary medicants include at least one selected from stem cells and modified genes. The system can include a chamber to enclose the fetus, a first fluid circuit including a source of a liquid, a pump configured to move the liquid, and a second fluid circuit including an oxygenator configured to transfer oxygen to the fetus. The umbilical cord of the fetus is connected to the second fluid circuit by attaching a first cannula connected to a vein of the umbilical cord, attaching a second cannula to a first artery of the umbilical cord, attaching a third cannula to a second artery of the umbilical cord, and connecting one or more of the first, second and third cannulae to the oxygenator via an oxygenation circuit.

An apparatus (1a) for extracorporeal blood treatment, comprising an infusion control arrangement (8) arranged for infusing a pre-dilution flow rate upstream a blood treatment unit (4) and a post-dilution flow rate downstream the blood treatment unit (4), an ultrafiltration, UF, arrangement (40) arranged for ultrafiltration of a liquid through a semipermeable membrane (7) of the blood treatment unit (4) and a control unit (31). The control unit (31) is configured to configure the infusion control arrangement (8) to obtain a plurality of different configurations of the pre-dilution flow rate and/or post-dilution flow rate. For each of the plurality of different configurations, the control unit (31) is configured to change an operating situation of the UF arrangement (40), to detect a plurality of ultrafiltration flow rate values through the membrane (7) as a function of TMP, on changing said operating situation, and to evaluate an optimal ultrafiltration flow rate value from a comparison of the detected ultrafiltration flow rates. The apparatus (1a) is also configured to estimate a clearance value for a certain solute at the optimal ultrafiltration flow rate value and to evaluate a preferred configuration of the pre-dilution flow rate and/or post-dilution flow rate from a comparison of the corresponding estimated clearance values.

A method for evaluating a patient's extracorporeal membrane oxygenation (ECMO) operation status includes: collecting the patient's oxygen saturation data, lactate data, and oxygen partial pressure data or mean arterial pressure data; based on oxygen partial pressure data, obtaining the oxygen partial pressure classification value through a pre-trained oxygen partial pressure classifier, or based on the mean arterial pressure data, obtaining the mean arterial pressure classification value through a pre-trained mean arterial pressure classifier; based on blood oxygen saturation data, obtaining the blood oxygen saturation classification value through the pre-trained blood oxygen saturation classifier; based on the lactate data, obtaining the lactate level classification value through the pre-trained lactate level classifier; determining the patient's ECMO operation score based on the blood oxygen saturation classification value, lactate level classification value, and oxygen partial pressure classification value or mean arterial pressure classification value.

The present invention provides for a removable second stage biocompatible substrate filter that includes biocompatible implant material configured to trap second stage operative particulate matter that may include at least one of bone fragments, plasma, stem cells, cellular matter, and growth factors captured from irrigation fluid. The second stage biocompatible substrate filter may be configured to combine with bone fragments captured from irrigation fluid by a first stage filter and may be configured to be operable with a reaming and collection device.

A blood reintroduction system can include a canister having a chamber configured to collect blood. A system may include an inlet configured to fluidically connect the chamber to a first tubing in fluid communication with an aspiration catheter. A system may include a first filter within the chamber, wherein the first filter is configured to separate blood from thrombus. A system may include a second filter downstream of the first filter, wherein the second filter is configured to separate blood from thrombus. A system may include a second tubing connected to an outlet of the chamber, wherein the second tubing is configured to reintroduce filtered blood from the chamber to a patient's vasculature.

A blood reintroduction system may include a canister configured to collect blood. The system may include an inlet configured to be fluidly connected to a first tubing in fluid communication with an aspiration system configured to apply aspiration to a vasculature of a patient. The system may include a first outlet configured to be fluidly connected to a second tubing in fluid communication with an aspiration pump. The system may include a second outlet configured to interact with a blood reintroduction device, wherein the blood reintroduction device is configured to withdraw the blood collected inside the canister. The system may include a filter positioned inside a flow path leading to the second outlet.