A hemodialysis system is provided including a dialyzer, a closed loop blood flow path, a dialysate flow path, and blood and dialysate pumps. A processor controls the flow of blood through the blood flow path, and the processor controls the flow of dialysate through the dialysate flow path. The hemodialysis system includes various sensors which are connected to the processor for providing data concerning various treatment parameters. The processor monitors the various parameters of the hemodialysis machine and applies one or more prestored algorithms, algorithms created by artificial intelligence (AI) or other forms of machine learning performed by the machine or calculated remotely, to more accurately predict and control the dialysate flow rate and/or blood flow rate. Preferred parameters being monitored by the processor to improve flow rate determination and control include pump head speed, inlet and outlet pressure, tubing age (measured by pump rotations), and fluid temperature.

A method for onsite hemorrhage control in trauma patients using a portable rapid autotransfusion device can involve recovering a first portion of patient blood from an extravascular space into a fluid reservoir of the device. A negative internal pressure can be applied to the blood. The blood can be conditioned, such as by oxygenating and removing carbon dioxide. The conditioned blood can be returned to the patient intravenously at a rate that matches the rate of blood recovery, ensuring that the net volume of returned blood is maintained substantially equal to the net volume of removed blood.

A CRRT apparatus comprising a control unit configured to execute a flow-rate setup procedure by receiving a patient prescription comprising clinical prescription parameters, by allowing entry of a set value for a prescribed dialysis dose (D.sub.set) to be delivered, and of a target value for a parameter (nNBL; Cp.sub.HCO3_PAT) indicative of a steady state acid-base balance in the blood of the patient who has to undergo a CRRT blood treatment, and by determining operating parameters calculating a set value of relevant fluid flow rates including one or more of a fluid flow rate (Q.sub.cit) through the anticoagulant infusion line, a fluid flow rate (Q.sub.PBP) through the PBP infusion line, a fluid flow rate (Q.sub.rep.pre) through the pre-dilution infusion line, a fluid flow rate (Q.sub.rep.post) through the post-dilution infusion line, a fluid flow rate (Q.sub.HCO3) through the post-dilution bicarbonate infusion line, a fluid flow rate (Q.sub.ca) through the ion balancing infusion line, a blood fluid flow rate (Q.sub.b) through the extracorporeal blood circuit, a fluid flow rate (Q.sub.dial) through the dialysis liquid supply line, and a fluid flow rate (Q.sub.eff) through the effluent fluid line, wherein calculating the set value of the fluid flow rates is based at least on the set value of the prescribed dialysis dose (D.sub.set) and on the target value for the parameter (nNBL; Cp.sub.HCO3_PAT) indicative of a steady state acid-base balance in the blood.

A method comprising obtaining a bodily fluid from a subject; contacting the bodily fluid with an adsorbent material comprising a synthetic carbon particle (SCP) to produce a first filtrate having a level of disease mediators (y); contacting the first filtrate with an adsorbent material comprising the SCP and an anion exchange resin where the ratio of SCP to anion exchange resin is in a range from about 0.1:100 to 100:0.1 to produce a second filtrate; contacting the second filtrate with an adsorbent material comprising the SCP and a cation exchange resin where the ratio of SCP to cation exchange resin is in a range from about 0.1:100 to 100:0.1 to produce a third filtrate.

Disclosed are catheters useful in dialysis treatment of a patient. In an example, a catheter includes a tip that has an arterial lumen that directs blood flow in the direction of a dialysis machine and a venous lumen that directs flow in a direction away from the dialysis machine. One or both of the arterial and venous lumens includes within it a spiral flow inducing structure that cause blood flow to rotate as it travels through the lumen. In particular applications the one or more spiral flow inducing structure are spiral laminar flow inducing structures.

Disclosed are apparatus and methods for blood and other biological fluid purification using a membrane with cell containing vascular channel systems and filtration channel systems. Also disclosed are methods of making the apparatus as well as methods of making membranes.

Aspects of this technical solution can include an assembly including an ostomy bag and an antegrade ostomy infusion device that is fluidly coupled to the ostomy bag. The antegrade ostomy infusion device includes a deformable reservoir that is configured to deliver a fluid from the ostomy bag to a patient's distal stoma.

Apparatuses and methods for performing transseptal extracorporeal membrane oxygenation are disclosed. The method may include puncturing a septum between the right atrium and the left atrium and advancing a catheter system through the puncture and into the aorta. The catheter system may include coaxially arranged and independently moveable venous and arterial sheaths having independently positionable openings for removing blood from the patient and for returning oxygenated blood to the patient, e.g., within the aorta.

A blood processing unit for use in connection with extracorporeal blood circulation includes a housing including a blood inlet, an upper end cap defining a central inlet opening, and a blood outlet. Blood flows along a blood flow path between the blood inlet and the blood outlet. A plurality of layers of hollow fibers are disposed inside the housing and along the blood flow path. The hollow fibers are fluidly coupled to a gas inlet port and a gas outlet port. The device includes a flow distribution structure for modifying blood flowing along the blood flow path. The structure includes a body having a distal end, a proximal end, and an outer surface extending between the distal end and the proximal end. An inlet configured for connecting with the upper end cap is spaced from the proximal end. A plurality of curved dividers extend between the inlet and the body.

Methods for aspiration to remove thrombus/clot material using a system configured to remove, filter and return clot. These methods allow the removal of clot material using a fluidically-driven aspiration device when attached to an aspiration catheter and proximate to obstructive clot material. A fluidic actuator drives an aspirator, which may be automatically controlled to apply a vacuum in a pattern to enhance clot removal and collection from the body as well as improve blood return using the same closed system. The fluidic actuator may direct the aspirated blood through a filter and deaerator to allow the filtered blood to be returned to the patient.