A system for filtering or treating blood of a subject is provided herein. The system includes a bone port for establishing fluid communication with a bone marrow of the bone and a return port for returning blood from the bone marrow to a circulation of the subject. The system further includes a blood treatment or filtering device interposed between the bone and return ports thereby establishing a mini-circulatory system.

This invention relates to a dialysis apparatus which ultra-filters blood and to a related method of ultra-filtering blood ex-vivo.

More preferably the invention relates to haemodiafiltration using protein-losing membranes and a secondary ultrafiltration and partial re-infusion of haemodiafiltrate for increasing extraction of middle molecules and protein bound uraemic toxins and reducing albumin loss.

This invention relates to a dialysis apparatus which ultra-filters blood and to a related method of ultra-filtering blood ex-vivo. More preferably the invention relates to haemodiafiltration using protein-losing membranes and a secondary ultrafiltration and partial re-infusion of haemodiafiltrate for increasing extraction of middle molecules and protein bound uraemic toxins and reducing albumin loss.