Provided herein are devices useful in processing fat for fat grafting and for delivering fat tissue grafts to a patient. Also provided are devices and methods for fat grafting and for treatment of plantar fasciitis.

Apparatus and methods for delivering medicament to a patient. The apparatus may include elements with different capacities to attenuate or absorb sterilizing radiation. The apparatus may include a medicament delivery assembly with interactive elements for dose-setting, priming and medicament ejection. The assembly may include a chamber housing a radiation-sensitive medicament present in the apparatus during sterilization by electron beam. The assembly may include an actuator chassis, a drive mechanism, a needle-priming mechanism and a fluid-displacement mechanism including a fluid-displacement member. The chassis may be fixed, relative to an outlet, to the chamber. The member may be slidingly and/or threadingly engaged with the chassis, and may be configured to move relative to the outlet to deliver the medicament through the outlet. Assembly elements may be nested coaxially and/or stacked axially. The assembly may include at least one hollow region. The hollow region may reduce beam attenuation or reduce radiation absorption.

A method of preparing adipose tissue for transplantation, from lobular fat extracted, for instance, by liposuction, said fat consisting of a fluid component comprising an oily component, a blood component and/or sterile solutions and of a solid component comprising cell fragments, cells and one or more cell macroagglomerates of heterogeneous size, characterized in that it includes at least one step of forming an emulsion of the fluid component in the sterile washing solution by means of active and/or passive stirring means and discharging the emulsion from the outlet through a density gradient.

A living cell transplanting device has a flexible tube capable of accommodating living cells and a cell pushing shaft inserted into the tube. The tube has a lumen penetrating therethrough and a reduced diameter front end open portion. The shaft has a small diameter end portion having a diameter smaller than that of the reduced diameter front end open portion and an enlarged diameter portion having an outer diameter larger than an inner diameter of reduced diameter front end open portion. Owing to contact between the enlarged diameter portion of the shaft and the reduced diameter front end open portion of the tube, a progress of the shaft is regulated. By pushing the shaft into the tube after the contact between the enlarged diameter portion and the reduced diameter front end open portion finishes, the enlarged diameter portion of the shaft passes through said reduced diameter front end open portion with expanding the reduced diameter front end open portion of the tube and projects beyond the reduced diameter front end open portion of the tube.

Described are devices and methods for use in connection with organ replacement or organ assist therapy in a patient.

(57) Abstract: Bioartificial ultrafiltration devices comprising a scaffold comprising a population of cells enclosed in a matrix and disposed adjacent a plurality of channels are provided. The population of cells provides molecules such as therapeutic molecules to a subject in need thereof and is supported by the nutrients filtered in an ultrafiltrate from the blood of the subject. The plurality of channels in the scaffold facilitate the transportation of the ultrafiltrate and exchange of molecules between the ultrafiltrate and the population of cells.

A device for the deposition of adipose tissue, comprising: a) a syringe for grafting the tissue, b) a system for controlling the advance of the plunger of the syringe, which receives information about the movement of the syringe in the direction of withdrawal from an external system for detecting the movement of the syringe, and c) an external system for detecting the movement of the syringe. The control system determines the advance of the plunger of the syringe on the basis of the movement of the syringe in the direction of withdrawal and on the basis of the quantity of adipose tissue per unit of length of deposition. The advantages deriving from the use of this device in lipomodelling (or fat grafting) are in an automatic control of deposition of the adipose tissue and a correct uniformity of the graft.

The objective of the present invention is for an object discharged from a discharge port to be less liable to form a jet flow, and less liable to cause injury to the central nervous system. A passage 11 for a cell is formed inside a needle body 10 of a puncture needle 1. A discharge port 15 for a cell is formed in a side surface 13b of a front end part 13 of the needle body 10. Furthermore, the needle body is a single tube provided with a passage for an object. Further, a discharge path 14 for a cell, oriented upward from the passage 11 toward the discharge port 15, is formed in the front end part 13. The discharge path 14 comprises a frustoconical part 14a and a columnar part 14b. As a result, the discharge path 14 is formed in such a manner that the surface area of a cross section orthogonal to the upward/downward direction increases smoothly towards the discharge port 15 in at least one part of the discharge path 14, and, in each position in the upward/downward direction, is equal to or greater than the surface area of a cross section in a position closer to the passage 11.

The present disclosure provides devices, kits and methods for preparing injections with cells and carrier components for delivery to a target area in the body. The disclosed devices, kits, and methods provide preparation and monitoring of injections.

A device for preparing adipose tissue for transplantation from lobular fat extracted, for instance by liposuction, said fat consisting of a fluid component comprising an oily component, a blood component and/or sterile solutions and a solid component comprising cell fragments, cells and one or more cell macroagglomerates of heterogeneous size, comprising at least one washing and separating container (1) having a washing chamber (101) for washing the liposuctioned material, which container (1) has an inlet (102) and an outlet (103) for the liposuctioned material to enter the washing chamber (101) through the inlet (102) and for at least part of said material, particularly the fluid component, to exit said chamber (101) through the outlet (103), said washing chamber (101) including means for forming an emulsion of fluid components, by mechanical stirring.