A plasmapheresis device includes a column or other flow mechanism in which plasma flows following separation of the plasma from cellular components like blood cells, platelets and the like. The column includes a moiety, such as an antibody, which selectively binds to galectin-3. By removing galectin-3 from the blood stream of a mammal by at least 10%, improvements in the treatment of inflammation, suppression of the formation of fibroses, and a variety of cancer treatments can be effected or improved. The device provides for multiple columns to remove a variety of elements but includes one which selectively removes galectin-3 from the blood flow. Other agents may be added to the plasma before recombination with the cellular components of the blood, and before returning the recombined flow to the patient.

A material chosen from alumina ceramic grafted with at least one aptamer, at least one antibody or their combination for capturing circulating foreign cells, preferably circulating tumor cells, the method of preparing such material, its use and the device comprising it are disclosed.

A skin regeneration therapy combining precise bioelectric signals, light, and biologics for skin treatment and regeneration. Precise bioelectric signals give clear instructions to the stimulated cell DNA/RNA to produce specific regenerative proteins on demand. Bioelectric signals give clear instructions to cell membranes on what to let in and what to let out and serve as an equivalent or surrogate of environmental stimuli to cause a cell action in response.

Provided herein are devices, systems, and methods for subcutaneous membrane, encapsulation chamber, or reservoir implantation comprising or employing an implantation device configured to insert a membrane, encapsulation chamber, or reservoir into a subject.

The invention relates to a method for the extracorporeal removal of pathogens and/or an excess of components from a cell sample of a human or animal patient suffering from an illness. The method comprises the steps: a) determination of at least one protein cluster (CMP) that is characteristic of the illness of the patient; b) preparation of the cell sample of the patient; and c) extracorporeal removal of components having the at least one determined protein cluster from the cell sample. The invention further relates to a device for carrying out said method.

A dermo-epidermal suspension spray device, said device comprising: a refill capsule (H) to contain skin pieces, said refill capsule (H) placed inside a sample loader (B); a stirrer mechanism to be connected to said refill capsule (H/14/24) so that a solution of skin pieces and saline is continuously stirred to maintain a uniformly suspended solution or skin pieces and saline in a non-homogenous stirred manner; a nozzle (A) to spray said uniformly suspended solution from said refill capsule (H/14/24) onto a portion of a body where grafting is required; an actuator (D) to enable spraying of said uniformly suspended solution; and air container (G) to store compressed air, said air container (G) connected to said refill capsule (H) so that said compressed air is used for spraying said uniformly suspended solution of skin pieces and saline through said nozzle (A).

The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration of symptoms for gastro-esophageal pathologies like gastro-esophageal reflux.

Disclosed are products having animal tissue packed within the lumen of a device such as a needle cannula. The needle cannula or other device can be received in a capsule and/or other container. Methods of use of the products are also described and can include ejecting the animal tissue from the lumen of device using pressurized liquid passed through the lumen, potentially to deliver the animal tissue directly into a patient. Methods of manufacture of the products are also described.

A tissue separating device (100) is provided. The tissue separating device (100) includes a canister device (20) including a canister body (21) defining a volume. A tissue retrieval port (36) can be arranged on the canister device (20) and is capable of being arranged in fluid communication with a harvesting device (300) for directing a fatty liposuction aspirate into the volume of the canister device (20). An adjustable height filtration mesh assembly (50) can be arranged within the canister body (21) and can include a filtering mesh (62). A tissue harvesting port (24) can be arranged in the sidewall of the canister body (21) and can be capable of being arranged in communication with a collection device (400) to allow the tissue harvesting port (24) to atraumatically receive a filtered pure fat collected on the filtering mesh (62). The filtration mesh assembly (50) can be movably arranged within the canister body (21) such that the filtering mesh (62) is adjustable with respect to the tissue harvesting port (24).

The dual syringe with percutaneous cannula is a medical device for harvesting and transferring cells for autologous transplantation without the requirement of a surgical setting or ambulatory care. The dual syringe is a closed sterile system that allows for the harvesting syringe to harvest the cells/tissue from a first location of a patient which is then centrifuged to aggregate the cells. The aggregated cell pellet is transferred to a transfer syringe. The cell pellet is then reinjected by the transfer syringe into the patient at a second location for therapeutic purpose. The percutaneous cannula permits insertion of a cannula, with the assistance of a needle, without the need of a surgical incision or trocar.