The present invention relates to a dissolvable microneedle comprising needles made of a water-soluble material assembled on one side of a base, which is a sheet material having liquid-permeable cavities, wherein the needles being assembled to the base such that bottom portion of the needles is directly connected to the base, the connection of the bottom portion of the needle s to the base forming through a structure in which the bottom portion of the needles penetrates into the base (102), occupying some or all cavities of the base. The dissolvable microneedle with the structure according to the present invention is convenient to use as the penetrating structure that connects the needle s to the base can be dissolved quickly and efficiently; therefore, the base can be removed from the top skin without the needles embedded within the skin being pulled out. Hence, there is no clearly visible remainder on the top skin, and the active agent contained in or coated on the needles can also be released more effectively.

A device, system, and method for facilitating a sleep cycle in a subject during a pandemic or peri COVID vaccination period, comprising determining a current awake or sleep stage of a person; automatically defining a desired sleep cycle pattern, dependent on the current awake or sleep stage of the person; generating an audio or optical stimulation pattern by an automated processor; and entraining brainwaves of the brain of the person with the stimulation pattern corresponding to the desired sleep cycle pattern, to thereby induce a sleep cycle in the person according to the sleep cycle pattern. When sleep patterns are normalized, a SARS-Cov-2 vaccination may be administered to the person.

A device, system, and method for facilitating a sleep cycle in a subject during a pandemic or peri COVID vaccination period, comprising determining a current awake or sleep stage of a person; automatically defining a desired sleep cycle pattern, dependent on the current awake or sleep stage of the person; generating an audio or optical stimulation pattern by an automated processor; and entraining brainwaves of the brain of the person with the stimulation pattern corresponding to the desired sleep cycle pattern, to thereby induce a sleep cycle in the person according to the sleep cycle pattern. When sleep patterns are normalized, a SARS-Cov-2 vaccination may be administered to the person.

A medical agent delivery device may comprise a laminate of a number of layers coupled together. The device may further comprise a collapsible reservoir within the laminate. The device may further comprise a sharp bearing body having at least one microneedle. The device may further comprise a collar element attached to the sharp bearing body. The device may further comprise a removable cover assembly including a microneedle encasing body coupled to the sharp bearing body and to a release liner. The microneedle encasing body may be attached more weakly to the sharp bearing body than to the release liner.

A mask system includes a cushion for a mask that seals at its upper extent in a region of the nose that is generally above the tip of the nose or pronasale, and extends across a portion of the cartilaginous framework, alar or flares of the patient's nose, e.g., not extending over or across the nasal bone of the patient's nose.

The invention relates to trans-epithelial frictionally abrasive tissue sampling devices for performing biopsies and methods of inducing an immune response against a pathogen, wherein epithelial cells containing the pathogen are disrupted with the frictionally abrasive tissue sampling device to introduce the pathogen into the bloodstream of a patient.

A device for delivering a predetermined amount of a substance within at least one body cavity of a subject, where the predetermined amount is at an effective amount for treatment of obesity or binge eating disorder. The device includes (a) A volume to contain the predetermined amount of the substance. (b) A delivery end placeable in proximity to the body cavity. The delivery end is in fluid communication with the volume and comprises at least one orifice. (c) A valve mechanically connected to the volume, with at least two configurations: (i) an active configuration configured to deliver the predetermined amount of the substance; and, (ii) an inactive configuration, in which the valve prevents delivery of the predetermined amount of the substance. (d) A fluid tight chamber configured to contain a predetermined volume of pressurized gas at a predetermined pressure.

A recombinant coronavirus vaccine is provided. Methods of making and delivering the coronavirus vaccine also are provided. A microneedle array is provided, along with methods of making and using the microneedle array.

A single dose aerosol chamber is used with a dispensing apparatus by users to take a chamber, fill the chamber with an aerosolized vaccine, and dispose of used chambers. A display provides instructions to encourage prompt inhalation by the user from a dispensed and filled chamber. The station allows very fast administration of vaccines to large numbers of people. The aerosol dispenser apparatus detects the chamber is in correct position and delivers a pre-determined dose of aerosol. The chamber has a nebulizer delivery port optimized for delivery of aerosol into the chamber container and to act as a vent during inhalation via the inhalation port.

A microneedle assembly that is capable of transdermal delivery of a drug compound, such as a vaccine, (e.g., vaccine) across a dermal barrier of a subject (e.g., human), and/or detecting the presence of an analyte in the subject is provided. The microneedle assembly comprises a plurality of microneedles arranged on a support that each contain a tip and base, one or both of which are formed from a polymer composition that includes a liquid crystalline polymer. By selectively controlling the specific components of the polymer composition, as well as their relative concentration, the resulting microneedles may exhibit a high degree of physical alignment, which can help ensure better performance during use of the microneedle assembly.