A respiratory conduit has a hollow tube having an inlet, an outlet, a longitudinal axis, and defining a fluid flow path. Along at least a length of the tube, an outer surface of the tube has alternate ridges and grooves. The respiratory conduit also has a sheath surrounding at least a portion of the length of the tube, the sheath has alternate attachment portions and bridging portions. The attachment portions contact the ridges of the tube. The bridging portions extend across the grooves of the tube. Each bridging portion has a span length being the distance in the longitudinal direction between adjacent attachment portions, and a depth being the maximum distance in a radial direction between a point on the bridging portion and a point on one of the adjoining attachment portions. The depth of the bridging portion is greater than zero.

An apparatus including a patient interface device formed from a flat substrate that is folded, wherein the patient interface device includes a plurality of seams where sections of the substrate are joined together, and wherein one or more of the plurality of seams form a shape that corresponds to a perimeter of a bottom side of a nose from a first alare corner of the nose to a tip of the nose to a second alare corner of the nose.

An injection configuration (10) for connection to a male Luer connector (100) includes a hub (12) having an internal conical taper (14) in fluid interconnection with a hollow needle (16). The internal conical taper has a convergence angle of 6% and a length L of 7.5-10.5 millimeters, and presents an entrance aperture diameter D of between 4.365 and 4.595 millimeters.

A medication inhalation apparatus preferably formed of a single, unitary sheet of stock, includes an outer housing, movable between collapsed and expanded states, encompassing a first volume. An inner housing within the outer housing encompasses an inner or second volume. An inhaler opening to the first volume is within a wall of the outer housing at a first location. A mouth opening to the inner volume is within a wall of the outer housing and the inner housing at a second location. A one-way inhalation valve connecting the first volume and the inner volume is within a wall of the inner housing. A one-way exhalation valve connecting the inner volume and the exterior of the outer housing is within a wall of the outer housing and inner housing at a third location. The valve preferably includes an elongated spring body formed of a semi-pliant material with a strength and rigidity providing limited flexibility. A first separation is perpendicular to the elongate axis of the spring body, and extends from a first edge of the spring body across at least a portion of a width of the spring body. A second separation perpendicular to the elongate axis of the spring body extends from a second edge of the spring body across at least a portion of the width of the spring body.

A patient interface including a seal-forming structure with a textile membrane that has at least one hole such that the flow of air at a therapeutic pressure is delivered to at least an entrance to the patients nares and/or an entrance to the patients mouth. The seal-forming structure is constructed and arranged to maintain the therapeutic pressure in a cavity of a plenum chamber throughout the patients respiratory cycle, in use. The textile membrane includes a first portion that is held in a relaxed state and a second portion that is held in a taut state. The taut state of the second portion is configured to allow the seal-forming structure to include a three-dimensional shape that has multiple curvatures.

Aspects of this disclosure relate to catheter assemblies, that include an inner tube component, an outer tube component that fits over the inner tube component, and a disposable layer of film that isolates the otherwise fluid-exposed portions of the catheter from the fluid it drains. This disposable film can be removed at regular intervals and obviates the need for catheter exchanges as the isolating disposable film, rather than the catheter itself, is removed. The principal characteristic of the disposable film is that it is relatively impermeable to fluid, for example, bodily fluids.

Provided is a device for transdermal delivery of drugs. The device includes a separable substrate and is loaded with dual drugs based on an interpenetrating polymer network hydrogel. Also provided are methods of making and using the transdermal delivery device.

A heat and moisture exchanger, comprises a rigid monolithic body (101). The rigid monolithic body (101) comprises a circumferential wall (102); and a structure of interconnected elements (106) surrounded by the circumferential wall (102). The structure (106) is open to fluid communication through the structure (106) between a first side (114) of the structure and a second side (115) of the structure (106) opposite the first side (114) of the structure (106). The circumferential wall (102) extends from the first side (114) to the second side (115) of the structure (106). The heat and moisture exchanger (100) is open on both of the first side (114) and the second side (115) of the structure (106), to allow fluid communication between the structure (106) and an exterior of the heat and moisture exchanger (100) on both sides (114, 115).

A holder for securing a venous access device to a patient may include a flexible substrate having an upper surface, a lower surface, and an outer perimetal surface. An adhesive layer may overlay the lower surface of the flexible substrate. The adhesive layer may have an adhesive for adhering to skin of the patient. The holder may further include a hydrophilic matrix integrated into at least a portion of the adhesive layer, at least one solvent reservoir disposed on the upper surface of the flexible substrate, and a connector secured to the outer perimetal surface. The connector may have a first end for connection to a needle assembly and a second end for connection to an IV fluid line.

A patient interface for treating sleep disorder breathing includes a textile tube that also provides support for the seal forming structure. The textile tube includes an inner and outer layer that are joined along seams to form an air chamber or passageway. The textile tube can be pre-shaped so that the textile tube resiliently returns to a pre-determined shape prior to the introduction of pressurized air.