Provided is a system (10) for determining a probability of a CORD exacerbation in a subject. The system comprises a first inhaler (100) for delivering a rescue medicament to the subject. The rescue medicament may be suitable for treating the subject's acute respiratory disease, for example by effecting rapid dilation of the bronchi and bronchioles upon inhalation of the medicament. The first inhaler has a use-detection system (12B) configured to determine a rescue inhalation performed by the subject using the first inhaler. The system optionally includes a second inhaler for delivering a maintenance medicament to the subject during a routine inhalation A sensor system (12A) is configured to measure a parameter relating to airflow during the rescue inhalation and/or during the routine inhalation, when the second inhaler is included in the system. The system further comprises a processor (14) configured to determine a number of the rescue inhalations during a first time period, and receive the parameter measured for at least some of the rescue and/or routine inhalations. The processor then determines, using a weighted model, the probability of the CORD exacerbation based on the number of rescue inhalations and the parameters. The model is weighted such that the parameters are more significant in the probability determination than the number of rescue inhalations. Further provided is a method for determining the probability of a COPD exacerbation in a subject, which method employs the weighted model.

A wound therapy device includes a wound dressing and a humidifier configured to deliver humid air to a wound site to which the wound dressing is applied. The humidifier may be a remote structure that is fluidly connected to the wound dressing applied about a patient's skin at a wound site. Alternatively, the humidified may be integrated with the wound dressing to define an integral, portable therapy device that may be worn by the patient. The wound therapy device may be a standalone wound treatment device, or may be used in conjunction with other wound treatment devices, such as, e.g., negative pressure wound therapy devices.

The present invention relates to an apparatus that provides therapeutic effects and a source of hydration. The apparatus includes a garment that has one or more compartments for storing a therapeutic element. The therapeutic element may include one or more herbs, essential oils, and combinations thereof. The apparatus also includes a portable drinking apparatus attached to the garment. The portable drinking apparatus includes a pouch having a liquid reservoir inserted therein and a drinking tube having a first end in fluid communication with the liquid reservoir and a second end having a mouth operated valve. Methods of use are also disclosed.

A system and method is provided for healing a wound in a subject in need thereof. The system includes a wound dressing that has a therapeutic agent and at least one electrode in electrical communication with the therapeutic agent. The system also includes a power source in electrical communication with the at least one electrode and a vacuum source in fluid communication with the wound dressing.

The instant invention provides an eyewear piece having a nasal mucosa heating and occlusion apparatus. The eyewear piece includes a bridge extending substantially across the wearer's face and having flexible joints at opposite ends thereof to attach temples, which extends over the ears to keep the eyewear on the wearer's face. The bridge includes a housing and depending therefrom is a nasal frame having nasal passageways to provide heat into the nasal cavity. It is contemplated that other therapeutic remedies are offered to the wearer.

Devices, systems, and methods for delivering fluid therapy to a patient are disclosed herein. An exemplary method can comprise obtaining a urine output rate from a patient; causing a diuretic to be provided to the patient at a dosage rate, wherein the dosage rate is increased over a period of time such that the urine output rate increases to be above a predetermined threshold within the period of time; and causing a hydration fluid to be provided to the patient at a hydration rate. The hydration rate can be set based on the urine output rate to drive net fluid loss from the patient.

Provided is a blood purifier which has a porous molded body with good phosphorus adsorption, which has good cytokine adsorption performance, no hemolysis, and can be used safely. The blood purifier has a porous molded body having a low-melting-point moisture content per gram of dry weight of 0.12 g or more and 1.35 g or less. After three and six months from sealing of a saline solution for injection into the blood purifier, the number of microparticles greater than or equal to 10 μm is 25 or less and the number of microparticles greater than or equal to 25 μm is three or less in 1 mL of the saline solution for injection.

A ventilator (1) with a respiratory device (2) for generating a respiratory gas flow for a ventilation and with a monitoring device (3) for monitoring a characteristic parameter (200) of the respiratory gas flow. A control device (4) is provided here and is suitable and configured to carry out a detection mode for a cardiac activity and to register for this a temporal profile (201) of the parameter (200) of the respiratory gas flow and to examine the temporal profile (201) of the parameter (200) for a profile structure feature (202) and to detect heartbeats in that the profile structure feature (202) fulfils a stored condition for a profile structure feature (202) which is caused by heartbeat.

An aspect of the present invention is a consciousness disorder mitigation apparatus, including: a first estimation unit configured to estimate body fluid volume information, the body fluid volume information being information on a body fluid volume present in a head of a user; a second estimation unit configured to estimate oxygen supply volume information, the oxygen supply volume information being information on an oxygen supply volume representing an amount of oxygen in a brain of the user; a pressurization unit configured to be attached to the user and to apply a pressure corresponding to an estimation result of the first estimation unit and an estimation result of the second estimation unit; and an oxygen supply unit configured to supply oxygen to the user based on the estimation result of the second estimation unit.

Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.