Systems and methods for providing resuscitative chest compressions to a chest of a patient are described. One exemplary system may include a chest compressor for administering chest compressions to the patient, one or more sensors for measuring and generating electrocardiogram (ECG) signals of the patient's heart. The system may include at least one processor coupled to memory and configured to receive and analyze the signals corresponding to the ECG, determine an intrinsic heart rate, identify at least one ECG waveform within the ECG signals, select a chest compression protocol from at least three or at least four predetermined chest compression protocols for administration to the patient based at least in part on the intrinsic heart rate of the patient, and control the chest compressor based on the selected chest compression protocol.

A mechanical insufflation-exsufflation device including an air source to provide positive airway pressure (PAP); a patient interface; at least one sensor to sense air pressure and flow at the patient interface; and a controller to control the air source to deliver at least one mechanically assisted cough to the patient in response to at least one of a target breathing flow and a target inhalation time period being sensed by the at least one sensor, and when the at least one of a target breathing flow and a target inhalation time period is not sensed, the controller is configured to control the air source to deliver each in a series of high-level PAP provided over a duration being followed by a low-level PAP provided over a duration, the series of high-level PAP increasing in pressure level and duration from a prior one in the series of high-level PAP.

Described is a low voltage, pulsed electrical stimulation device for controlling expression of growth differentiation factor 10 (“GDF10”), a useful protein, by tissues. Also described are methods of enhancing expression of GDF10 in cells, particularly a method of stimulating the expression and/or release of GDF10 in a cell having a gene encoding GDF10, wherein the method includes applying a bioelectric signal produces, as measured at the level of the target cells or tissues being stimulated 2 mA to 4 mA direct current positive to the cell (e.g., directly, indirectly, or wirelessly). Applications in the treatment of cerebral strokes, brain injuries, paralysis, brain cancer, Alzheimer's disease, dementia, anxiety, Parkinson's disease, and/or essential tremors are also disclosed.

A waste collection system for collecting medical waste. A mobile rover includes at least one waste container, and a rover controller. A chassis is removably couplable with the mobile rover and includes a vacuum regulator, and a chassis controller. The chassis controller is configured to control operation of the vacuum regulator based on a pressure signal from a pressure sensor disposed on the mobile rover. The chassis may include a control panel configured to receive an input of and display a vacuum level, and the chassis controller may control operation of the vacuum regulator based on the input. The mobile rover may include plural waste containers, and the chassis may include plural vacuum regulators. The chassis controller may control operation of the vacuum regulators on the chassis to independently regulate the vacuum level supplied to each of the waste containers on the mobile rover.

Systems and methods for Endovascular Perfusion Augmentation for Critical Care (EPACC) are provided. The system may include a catheter having an expandable aortic blood flow regulation device disposed on the distal end of the catheter for placement within an aorta of a patient. The system may also include a catheter controller unit that causes the expandable aortic blood flow regulation device to expand and contract to restrict blood flow through the aorta. The system may also include one or more sensors for measuring physiological information indicative of blood flow through the aorta, and a non-transitory computer readable media having instructions stored thereon, wherein the instructions, when executed by a processor coupled to the one or more sensors, cause the processor to compare the measured physiological information with a target physiological range associated with blood flow through the aorta such that the catheter controller unit automatically adjusts expansion and contraction of the expandable aortic blood flow regulation device to adjust an amount of blood flow through the aorta if the measured physiological information falls outside the target physiological range.

A prosthesis including a device configured to deliver a therapeutic substance from outside a cochlea to inside the cochlea and configured to evoke a mechanically based hearing percept. In an exemplary embodiment, the device is configured to drive fluid into and out of the cochlea, thereby evoking a hearing percept.

Apparatus and methods for treatment of bleeding and/or microbial infection of the genitourinary tract including a catheter and an insertable and removable medicament-delivery sheath for introducing a hemostatic and/or anti-microbial substance or the like. Some embodiments further include a light-delivery sheath and/or light-delivery-and-imaging sheath having a light-propagation channel, and a source of anti-microbial and/or imaging light in one or more wavelength bands, for example UVC light and/or light in the visible violet, blue or green wavelength ranges. Some embodiments include a display for captured images, and/or a motorized sheath-movement device configured to move one or more light-output ports. Some embodiments further include a light-propagation channel built into the catheter itself (such as one or more optical fibers) for the administration of anti-microbial ultraviolet light (and/or other wavelengths of light) light along the catheter and/or at the distal end of the catheter to treat and/or prevent microbial (bacterial and/or fungal) infections.

A skin regeneration therapy combining precise bioelectric signals, light, and biologics for skin treatment and regeneration. Precise bioelectric signals give clear instructions to the stimulated cell DNA/RNA to produce specific regenerative proteins on demand. Bioelectric signals give clear instructions to cell membranes on what to let in and what to let out and serve as an equivalent or surrogate of environmental stimuli to cause a cell action in response.

Systems and methods of treating a sleep disorder of a subject include providing a therapeutic stimulation device comprising a transducer configured to emit transcutaneous vibratory output to a body part of the subject; generating physiological data with a worn sensor and providing it to a processor; providing a stimulation pattern for transcutaneous vibratory output to be emitted by the transducer comprising a perceived pitch, a perceived beat, and an intensity; causing the transducer to emit the transcutaneous vibratory output in the stimulation pattern; determining if the subject is in a pre-sleep state or a sleep state based on the physiological data; and altering the stimulation pattern based on determining the subject is in at least one of a pre-sleep state or a sleep state comprising at least one of (i) reducing a frequency of the perceived pitch, (ii) increasing an interval of the perceived beat, or (iii) reducing the intensity.

Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.