A skin grafting system having a handheld device, a cartridge, and a device shield. The handheld device includes a device housing forming an interior that secures a drive system. The cartridge includes a plurality of hollow microneedles surrounded by a peripheral housing and is configured to be operated by the drive system to extend and retract past the peripheral housing into a subject to harvest tissue during a skin grafting process. The device shield is formed of a polymer extending from an interior opening to an exterior edge, the interior opening sized to extend about the peripheral housing to positon the exterior edge over the device housing to control ingress of fluids into the interior of the device housing from fluid about the peripheral housing of the cartridge during the skin grafting process performed using the skin grafting system.

A medical treatment system, such as a peritoneal dialysis system, may include a control and other features to enhance patient comfort and ease of use. For example, a cycler device may include a heater bag receiving section and a lid mounted to cover and uncover the heater bag receiving section, potentially enabling faster heating of a dialysate. A user interface may be moveable to be received into the receiving section and covered by the lid, if desired. The system may detect anomalous conditions, such as tilting of a housing of the system, and automatically recover without terminating a treatment. The system may include noise reduction features, such as porting pneumatic outputs to a common chamber, and others. The system may also automatically detect any one of several different solution lines connected to the system, and control operation accordingly, e.g., to mix solutions provided by two or more lines and form a needed dialysate solution. A cassette control surface may be arranged to have one or more ports that can detect a presence of a liquid, e.g., to identify if a cassette is leaking or has otherwise been compromised.

Methods and systems for maintaining patient fluid balance during an extracorporeal cell treatment are disclosed. The method includes minimizing the amount of saline or other fluid that is returned to the donor. Saline used during priming of the fluid circuit may be used to increase the volume of the collected cells to arrive at a treatment-ready product with a suitable hematocrit.

Methods, device, and systems for preparing peritoneal dialysis fluid and/or administering a peritoneal dialysis treatment are disclosed. In embodiments, peritoneal dialysis fluid is prepared at a point of use automatically using a daily sterile disposable fluid circuit and one or more long-term concentrate containers that are changed only after multiple days (e.g. weekly). The daily disposable may have concentrate containers that are initially empty and are filled from the long-term concentrate containers once per day at the beginning of a treatment.

A cassette for a drug delivery device is described that includes a sleeve, a syringe having a barrel disposed in the sleeve, and a plunger-stopper slidably disposed within the barrel. An end cap is adapted to couple to the sleeve to secure the syringe in the sleeve. The cassette further includes a spacer that is sized to be slidably moved within the barrel and the spacer is disposed distal to the plunger-stopper to be engaged by a plunger rod to slide within the barrel and engage the plunger-stopper. In some forms, the spacer can be coupled to the end cap.

A water purification unit (30) fluidly connectable to a peritoneal dialysis preparator (50/60) and a cycler. The purification unit is connectable to a water source (20) and has a pump for flow of fluid from the unit to a purified water reservoir (40), the reservoir being fluidly connectable to the preparator which has a number of solute containers for dissolution of the solutes; each container being fluidly connectable to a chamber for receiving a solution of the solutes for preparation of a peritoneal dialysis fluid and the chamber being fluidly connectable to the cycler for the delivery and drainage of the peritoneal dialysis fluid to and from a patient. Purified water delivery to the reservoir is controlled by a first pressure sensor (72), and a second pressure sensor (74) between the reservoir and preparator provides a pressure differential between the first and second sensors to control a flow generator (76).

Aspects of this disclosure relate to a pump cassette with a radio frequency identification (RFID) tag. The RFID tag can store information associated with the pump cassette, such as usage information and/or a unique identifier. The RFID tag can be embedded in a component of the pump cassette in certain embodiments. Related infusion pumps, infusion sets, and infusion systems are disclosed.

Fluid processing assemblies and methods are provided for mononuclear cell collection. Mononuclear cells are separated from red blood cells in a blood separation chamber, with the mononuclear cells and then the red blood cells exiting the chamber via an outlet port. The mononuclear cells and then the red blood cells enter an outlet flow path that is in fluid communication with a mononuclear cell collection container. The outlet flow path includes a visual indicium, which an operator may use to determine the position of the red blood cells within the outlet flow path and when to end mononuclear cell collection by preventing fluid communication between the outlet flow path and the mononuclear cell collection container.

A method of sanitizing liquid for use in a. medical device, the method comprising the steps of providing a medical device defining a water circuit with a volume of liquid, sensing the temperature of the volume of liquid with a sensor, heating the volume of liquid from an initial temperature to exceed a threshold temperature, maintaining the volume of liquid above the threshold temperature, determining a time-temperature value for the volume of liquid periodically once the threshold temperature has been exceeded, calculating a. cumulative time-temperature value and providing an output signal once the cumulative time-temperature value has reached a level indicative of a sanitizing dose. A medical device and a liquid sanitizer are also disclosed.

A drug delivery device includes a first subassembly having a cap, a needle cover, a syringe holder configured to receive a syringe assembly, a cassette body, and a lower housing shell, with the cap receiving at least a portion of the needle cover, a second subassembly, including a drive assembly configured to move a stopper of a syringe assembly, and a motor body, with the motor body receiving at least a portion of the drive assembly and the cassette body of the first subassembly configured to receive at least a portion of the motor body, and a locking clip configured to secure the first subassembly to the second subassembly upon assembly of the first subassembly to the second subassembly.