The present invention relates to an inhaler which is appropriate for delivery of medicament in dry powder form used in respiratory diseases, particularly in asthma and chronic obstructive pulmonary disease (COPD). In addition, the present invention relates to an inhaler which includes a blister package appropriate for carrying the medicament in dry powder form and used to realize an effective inhalation.

Syringe assemblies comprising a disinfecting reservoir collar to ensure an adherence to aseptic techniques for use in flush procedures for vascular access devices (VAD's) are described. Also described are methods of disinfecting the vascular access devices.

A pre-filled syringe is disclosed, comprising a barrel and a plunger, the barrel having an outlet, the barrel containing a pharmaceutically acceptable solution having a non-physiological pH, wherein the syringe further comprises an ion exchange material. The ion exchange material is provided at a position to allow contact with the pharmaceutically acceptable solution upon ejection of the Pharmaceutically acceptable solution from the barrel via the outlet. The ion exchange material is capable of adjusting the pH of the solution from a non-physiological pH, at which the pharmaceutically acceptable solution is stored in order to ensure acceptable shelf life, to a more physiological pH at which the discomfort and/or pain experienced during injection may be alleviated.

A doser including one or more cartridges for holding one or more products. The cartridge has a body defining a cavity for holding the products, a nozzle disposed on the body and connected to the cavity for dispensing the product from the cavity, and a piston arranged to move within the cavity to propel the product from the cavity into the nozzle. The cartridge also has a cap removably coupled to the cartridge for protecting the nozzle. Lastly, the doser has a dispenser for holding the cartridge or cartridges which actuates the piston, and removes the cap from the cartridge, so that the product is dispensed from the cartridge.

In a syringe, which is a prefilled syringe, when a cap body is attached to a cylindrical portion, a first sealing section is compressed radially inward by an inner peripheral surface constituting an opening of the cylindrical portion, thereby sealing a distal end section of a flow path in a liquid-tight manner, and a second sealing section is compressed radially inward by an inner peripheral surface of a proximal end section of the cylindrical portion, thereby sealing a proximal end section of the flow path in a liquid-tight manner.

A plunger rod system for syringes is provided. The system comprises at least one plunger and an associated rod for imparting force to the plunger. The rod comprises an end with a threaded member, and the threaded member comprises threads of a certain geometry that enable ease of installation of the rod within the plunger while also providing resistance to pull-out forces such as may be imparted when pulling or extracting the rod or plunger from a barrel.

Compositions, methods and delivery devices (e.g., pre-filled syringes) for controlling bleeding during surgical procedures are provided, wherein the compositions are characterized as having an aqueous formulation that is capable of adopting a gelled state upon contact with bodily fluids and/or blood of a patient (i.e., physiological conditions).

A perimeter fill syringe is disclosed, wherein the syringe includes a solid core, allowing fluid to fill an area around the perimeter of the syringe barrel, enabling a wider diameter for the barrel thus increasing the visibility of the markings and ease of handling by a user.

The present invention relates to a medicament delivery device for delivering a number of predetermined amounts of medicament, comprising a body having a proximal and an opposite distal end and extending along a longitudinal axis (L); a medicament container (20) arranged inside said body; a driving mechanism arranged inside said body and configured to act on said medicament container; a manually movable activation member (102) arranged on the distal end the body; a biased actuator member (64) arranged to be movable along the longitudinal axis and through the manually movable activation member (102), said biased actuator member being configured to protrude a predetermined distance from the distal end of the manually movable activation member and configured to interact with said driving mechanism when the biased actuator member is displaced said predetermined distance towards the proximal end of the body for delivering a predetermined amount of medicament; and an actuator guide member (90) arranged in the body and configured to interact with the manually movable activation member (102) and with the biased actuator member (64) such that said actuator guide member (90) can be held in a position within the body and released from said position after a predetermined amount of medicament is delivered; wherein the actuator guide member (90) comprises at least one second guide element (92) adapted to interact with blocking surfaces in at least one group of guide surfaces (76) arranged on the outer circumferential surface of the biased actuator member (64) if said biased actuator member is operated towards the proximal end of the body during displacement of the biased actuator member (64) from the distal end of the manually movable activation member or if said biased actuator member is released during displacement of the biased actuator member (64) towards the proximal end of the body.

An injection device for injecting a solid dose formulation into a human or animal body, the injection device comprising an actuator having a cassette mounting portion; a cassette holder having a cassette storage portion; and a cassette selectively movable between the cassette storage portion and the cassette mounting portion, wherein, the cassette comprises a solid dose formulation and the actuator is receivable in the cassette holder to selectively move the cassette between the cassette storage portion and the cassette mounting portion.