Assembly for dispensing a fluid product, having a nasal fluid product dispenser with a reservoir containing the fluid, a dispensing member, and a dispensing head on the dispensing member, the dispensing head provided with a dispensing orifice, a remote mobile device attached to the user's head, such as an earpiece, the nasal device and the remote mobile device attached to the user's head each having an orientation sensor, such as an accelerometer or a gyroscope. The orientation sensors cooperate to determine the position of the nasal dispenser in the nostril. The nasal dispenser has an indicator visible when the dispenser is in the nostril, to guide the user towards an optimal orientation of the nasal dispenser in the nostril. The nasal dispenser having an electronic module and automatic actuation mechanism that automatically actuates the nasal device when the orientation sensors detect that the nasal dispenser is arranged in an optimal position.

A device for nasal delivery of fluid product, having a reservoir containing a fluid, a delivery member, and a delivery head on the delivery member, and the delivery head provided with a delivery opening. The nasal device has a camera for determining the spatial positioning of the nasal device inside a nostril, the camera determining the vertical tilt angle and the lateral tilt angle between the longitudinal axis of the nasal device and an axis of the face identified by a plurality of reference points, the orientation of the axis with respect to the nostril identical to whatever the position of the user, a positioning indicator for guiding the user towards an optimal orientation of the nasal device inside the nostril, and an electronic module and automatic actuation mechanism for automatically actuating the nasal device when the camera determines that the nasal device is disposed in an optimal position.

A nasal droplet delivery device and related methods for delivering precise and repeatable dosages to a subject via the nasal passageways and sinus cavities is disclosed. The droplet delivery device includes a housing, a nosepiece, a reservoir, an ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically actuated by the user when the differential pressure sensor senses a predetermined pressure change within the nosepiece. The droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter of greater than about 6 microns, preferably greater than about 10 micron, so as to target the nasal passageways and sinus cavities of the user.

An ejector mechanism, droplet delivery device and related methods or delivering small droplets to the respiratory system of a users disclosed. The ejector mechanism comprises a piezoelectric actuator and an aperture plate, the aperture plate having and a plurality of openings formed through its thickness, wherein at least the fluid entrance side of one or more of said openings is configured to provide a surface contact angle of less than 90 degrees and the piezoelectric actuator is operable to oscillate the aperture plate at a frequency to thereby generate an ejected stream of droplets during use. The droplet delivery device is automatically breath actuated by a user when the differential pressure sensor senses a predetermined pressure change. The ejector mechanism is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range having a diameter of less than about 4 um so as to target the respiratory system of the user.

A power pack for use with a medicament delivery device is presented having a plunger rod movable along a longitudinal axis; a drive spring operably connected to said plunger rod; a plunger rod sleeve arranged with holding elements for releasably holding said plunger rod with said drive spring in a tensioned state. Signal initiating elements are arranged to said plunger rod; and signal generating elements arranged to cooperate with said signal initiating elements for providing information to a user of a medicament delivery device about the movement of said plunger rod when said plunger rod sleeve has been activated to release said holding elements.

A feedback mechanism for an injection device that is configured to deliver a medicament to a user is described. The feedback mechanism has a biasing member that is arranged to apply a force to a delay element, and the delay element is configured to deform and/or break under the force. The feedback mechanism also includes an indicator arranged to generate user feedback after the delay element is deformed and/or broken. The delay element is configured to deform and/or break at a time after the force is applied by the biasing member to create a delay before the user feedback is generated.

A drive mechanism for a medicament delivery training device is presented having a plunger rod having a proximal end and a distal end, a stopper provided on the proximal end of the plunger rod, and a container having an inner chamber, a proximal container end, and an open distal container end leading into the inner chamber, wherein the inner chamber has a distal portion and a proximal portion, wherein in an initial state of the delivery mechanism the plunger rod is axially fixedly arranged in a first position in which the stopper is arranged distally relative to the proximal portion, and the plunger rod is biased towards the proximal container end, and wherein the plunger rod is configured to be released from the first position, causing the plunger rod to move towards the proximal container end and the stopper to impact with a stopper contact surface, resulting in an initial signal, and to subsequently move into the proximal portion.

An inhaler device for pulmonary delivery of at least one substance from a drug dose cartridge to an inhaling user, including: a first conduit for conducting a carrier airflow to a proximal opening of a mouthpiece for use by the user; a holder configured to position the dose cartridge within the carrier airflow; and a second conduit for conducting a shunting airflow to the mouthpiece without passing through the dose cartridge position. In some embodiments, a controller connected to a valve controls a rate of carrier airflow, for example by controlling the shunting airflow, based on a sensor indication of airflow rate and a target airflow profile.

A respiratory device provides respiratory support to a patient. The respiratory device includes an expandable bag and a rigid valve housing. The expandable bag has an air inlet valve as well as a first and second sides that are bounded, respectively, by first and second rigid side panels. Each of the first and second rigid side panels includes a biasing member projection. The rigid valve housing is in fluid communication with the expandable bag. The rigid valve housing includes an adjustable tidal volume control device that interfaces with the biasing member projection of each of the first and second rigid side panels to set one of a plurality of predetermined tidal volumes for the expandable bag in an uncompressed or compressed configuration. The rigid valve housing additionally includes a patient breathing interface connection member.

A facemask includes a facemask body, a plurality of electrical contacts and a control circuit. The facemask body has an end including an opening and a skin contact perimeter extending along a periphery of the opening, with the skin contact perimeter configured to sealingly engage with a user's face. Each electrical contact is disposed at a respective region of the skin contact perimeter, and each electrical contact is configured to sense when the respective region of the skin contact perimeter is sealingly engaged with a user's face. The control circuit is disposed on the facemask body, and the control circuit is configured to receive a signal from each electrical contact when the respective region of the skin contact perimeter is sealingly engaged with a user's face and to initiate output of an audible stimulus and/or a visual stimulus in response to receiving a concurrent signal from all of the plurality of electrical contacts.