A system for measuring injection of a liquid medicine includes a syringe body having proximal and distal ends, a syringe interior, and a syringe flange at the proximal end thereof. The system also includes a stopper member disposed in the syringe interior. The system further includes a plunger member coupled to the stopper member and configured to be manipulated to insert the stopper member distally in the syringe interior relative to the syringe body. Moreover, the system includes a needle coupled to the syringe body at the distal end thereof. In addition, the system includes a sensor flange removably coupled to a syringe body. The sensor flange includes a sensor to measure an injection characteristic and a processor to analyze the injection characteristic to determine an occurrence of an injection event.

A computer-implemented method includes receiving a signal associated with a characteristic of an actuation event of a medicament delivery device. The method includes establishing a communications link (e.g., via a short-range wireless protocol), between a mobile computing device and a medicament delivery device. A wireless first signal associated with a first motion profile of the medicament delivery device is then received from the medicament delivery device. A second signal associated with a second motion profile of the mobile computing device is generated. The method then includes producing a notification via the mobile computing device when A) a magnitude of the first motion profile is outside of a first threshold and B) a magnitude of the second motion profile is outside of a second threshold.

Topical ocular delivery devices are provided. Aspects of the devices include a transducer configured to oscillate at an amplitude and frequency that provides for an emitted stream velocity which results in minimal discomfort during topical ocular delivery. Also provided are methods of using the devices, e.g., in topical ocular delivery applications.

The disclosure relates to an audible indicator in combination with a drug delivery device having a resilient force member capable of resting in either of two states. In a biased state, the resilient force member is biased and stores energy and in a relaxed state, the resilient force member is relaxed. The resilient force member releases the stored energy when changing from the biased state into the relaxed state, thereby generating an audible signal, wherein the resilient force member is supported by a retaining element in the biased state in order to prevent transition into the relaxed state.

The disclosure relates to a drug delivery device comprising a case adapted to hold a medicament container, a plunger disposed within the case and slidable from a proximal position into a distal position for delivering a medicament (M) from the medicament container, an audible indicator that is arranged within a case pocket lateral to the plunger and that is in operative connection with the plunger, the audible indicator comprises at least one indicator spring and at least one locking element, wherein the indicator spring is biased by the locking element, and the indicator spring relaxes due to a release of the locking element by a movement of the plunger.

The disclosure relates to an audible indicator for use with a drug delivery device comprising a bistable resilient force member capable of residing in two states. In a biased state, the resilient force member is biased and stores energy In a relaxed state, the resilient force member is relaxed. The resilient force member releases the stored energy when transitioning from the biased state into the relaxed state, thereby generating an audible signal.

An acoustic device for spirometric measurement is provided. The acoustic device includes an inlet conduit configured to receive an airflow and a central cavity in communication with the inlet conduit. The central cavity includes a channel configured to guide at least a portion of the airflow into a vorticial flow about a central axis of the central cavity. The acoustic device further includes an outlet conduit configured to receive at least a portion of the vorticial flow and transduce at least a portion of kinetic energy of the vorticial flow into an acoustic emission. A frequency of the acoustic emission varies based on a rate of the airflow provided to the inlet conduit. In addition, the acoustic device includes a flow controller configured to modify at least a portion of the airflow provided to the inlet conduit.

A power unit (15) for use in an autoinjector (10) for driving a plunger (500) distally along an axis in an expelling movement so as to expel a drug from a held drug container, the power unit (15) comprising: a) a plunger (500) comprising retaining geometries (515) and defining radially protruding click protrusions (525), b) a drive spring (550) arranged in a tensed state with a force biasing the plunger (500) distally, and c) a power base (400) coupled to the drive spring (550) and the plunger (500), the power base (400) comprising a base part grounding the drive spring (550), and retaining elements (410) releasably engaging retaining geometries (515) of the plunger (500), the power base (400) further defining a resilient click arm (410) configured to cooperate with the click protrusions (525) of the plunger (500), the click arm (410) being moved radially to provide a click noise for each click protrusion that passes the click arm during the expelling movement, wherein the click arm (410) comprises a straining surface geometry (415d) arranged to cooperate, in a preparing step, with a tool (20) arranged distally relative to the click arm for moving the click arm (410) radially into a tensed state enabling the plunger (500) to be moved proximally. A method of assembling the power unit (15) is further disclosed.

The disclosure relates to an audible indicator for use with a drug delivery device comprising a bistable resilient force member capable of residing in two states. In a biased state, the resilient force member is biased and stores energy In a relaxed state, the resilient force member is relaxed. The resilient force member releases the stored energy when transitioning from the biased state into the relaxed state, thereby generating an audible signal.

An auto-injector having a body (1) receiving a reservoir (S) and including a piston (P); a piston rod (5) movable between a primed position and an injection position in which the piston rod (5) has moved the piston (P) to inject fluid into an injection site; and a visual, audible, and/or tactile indicator device for indicating that the autoinjector may be removed from the injection site. The autoinjector includes a retarding system to delay actuating the indicator device relative to the end of injection and that includes a dashpot (16), a shear member (19) and a fluid. The dashpot or the shear member is rotatably mounted in the body and the other is stationary in rotation, the turning of one relative to the other being braked by shearing the fluid contained in the dashpot. The dashpot and shear member include projections that impede the flow of the fluid.