A patient interface for use in delivering a flow of breathing gas to an airway of a patient. The patient interface includes a front portion and a rear portion coupled to the front portion. The front portion and the rear portion together define a cavity therebetween which is structured to receive the flow of breathing gas. The rear portion includes a support layer disposed directly adjacent the cavity, the support layer having a region having a plurality of first thru-holes structured to receive the flow of breathing gas from the cavity. The rear portion further includes a patient engaging layer structured to engage the patient at or about the airway of the patient, the patient engaging layer including at least a second thru-hole structured to receive the flow of breathing gas from the plurality of first thru-holes.

The cartridge includes a housing and a reservoir configured to contain a pre-vapor formulation. A first tube extends longitudinally within the housing, the first tube at least partially defining an air passage. A vapor generator is in communication with a first portion of the air passage, where the vapor generator is configured to communicate the pre-vapor formulation from the reservoir to the first portion and at least partially vaporize the pre-vapor formulation. A first air inlet is defined by the cartridge, where the first air inlet is in communication with a second portion of the air passage, the second portion being upstream of the vapor generator. A dilution air passage is defined by the cartridge, where a discharge end of the dilution air passage intersect a third portion of the air passage that is downstream of the vapor generator. The method makes the cartridge. The e-vaping device includes the cartridge.

A fluid collection apparatus for use in negative pressure wound therapy. The fluid collection apparatus includes a flexible bag having a first opening and a second opening. The bag includes a structure defining a fluid pathway connecting the first opening and the second opening. The pathway is circulative and contributes to orientation independence of the bag in use. The bag further includes a load-bearing component.

A medical device including an introducer; a first section configured to connect to a supply of therapeutic fluid; and a second section configured to connect to a supply of therapeutic elements. The therapeutic elements are drawn into the introducer by way of suction created by a flow of the therapeutic fluid through the introducer. The therapeutic elements are drawn into the introducer by way of suction created by a flow of the therapeutic fluid through the introducer.

A filter cartridge assembly is disclosed, which includes a housing having a reservoir for collecting fluids entering the housing through a gas return path, a sensor located within the reservoir for detecting a fluid level therein, and a backer plate positioned within the housing adjacent an inlet port to the reservoir and including fluid management structure to shield the sensor from fluid entering the reservoir from the gas return path through the inlet port and causing a false indication of the fluid level in the reservoir.

A microneedle array assembly includes a microneedle array that has a plurality of microneedles. A distribution manifold includes a fluid supply channel that is coupled in flow communication to a plurality of resistance channels. Each of the resistance channels are coupled in flow communication to a respective one of the microneedles of the microneedle array. The resistance channels have a resistance value to a fluid flow through each resistance channel that is in the range between about 5 times greater to about 100 times greater than a resistance to the fluid flow through the supply channel.

In a respiratory apparatus for treatment of sleep apnea and other disorders associated with an obstruction of a patient's airway and which uses an airflow signal, an obstruction index is generated which detects the flattening of the inspiratory portion of the airflow. The flattening index serves as an obstruction index used to differentiate normal and obstructed breathing. The obstruction index is based upon comparison of values of airflow in different sectors of the inspiratory peak of the wave function and is particularly suitable for distinguishing M shaped or square shaped respiratory patters patterns indicative of partially obstructed airways.

A nasal drug delivery device for delivering a plume derived from a propellant and a drug compound. The drug compound is in an intranasal dosage form in the form of powder, suspension, dispersion, or liquid. The propelled intranasal dosage form is deposited within the upper nasal cavity such as the olfactory region. The drug deposited within the olfactory region is delivered to the brain avoiding the blood-brain-barrier. Hydrofluoroalkane propellant from a pressurized canister is channeled to a diffuser and drug-containing channel where the intranasal dosage form is aerosolized. The aerosolized intranasal dosage form passes through a nozzle thus delivering a plume to the user's upper nasal cavity.

A respiratory interface (100) for delivering gases to a single nare of a patient; comprises of a gases delivery assembly having a single sealing nasal prong (200) configured to seal with one of the nares of a patient, a conduit (300), a conduit connector (400) and a support (500) with headgear strap clips (503). The prong slides relative to the support to be interchangeable such that it can engage and seal with either nari. A cuff (250, 1250) is connected to slider members (501, 1501). In another embodiment (FIGS. 33-49), the headgear strap (2600) is coupled directly to the prong; the strap (2600) is received between includes cutouts (2241) of the prong (2200) and a cuff (2250).

In a respiratory apparatus for treatment of sleep apnea and other disorders associated with an obstruction of a patient's airway and which uses an airflow signal, an obstruction index is generated which detects the flattening of the inspiratory portion of the airflow. The flattening index serves as an obstruction index used to differentiate normal and obstructed breathing. The obstruction index is based upon comparison of values of airflow in different sectors of the inspiratory peak of the wave function and is particularly suitable for distinguishing M shaped or square shaped respiratory patters indicative of partially obstructed airways.