Methods and devices for bending a needle are provided. A device embodiment can include a needle bending apparatus for imparting a bend in a needle when a needle is received therein. The needle bending apparatus may include a housing having an aperture for receiving a shaft of a needle; and at least one abutment member comprising a needle interfacing surface for supporting a portion of the needle and providing a surface upon which the needle may be bent.

Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a container including a wall with an interior surface and a seal member with an end surface. The interior surface of the wall and the end surface of the seal member may define a reservoir filled with a drug. A fluid pathway assembly may be connected to the container and include an overmold member that covers a length of a container access needle and which defines an enclosed space with the seal member. The overmold member may be moveable relative to the seal member to carry the container access needle between a storage position, where a point of the container access needle is disposed exterior to the reservoir, and a delivery position, where the point extends through the end surface of the seal member into the reservoir.

A liquid formulation of an ophthalmic drug in a pharmaceutical package, for example a syringe, cartridge, or vial, made in part or in whole of a thermoplastic polymer, coated on the interior with a tie coating or layer, a barrier coating or layer, a pH protective coating or layer, and optionally a lubricity coating or layer.

The invention relates to a piston stopper (10) for a medical syringe (1) wherein the piston stopper (10) has an end wall (11), a lateral wall (12) and an internal thread (16) for securing a piston rod (7). The piston stopper (10) comprises a main body (10a) which made of a cycloolefin, in particular a cycloloefin copolymer or a cycloolefin polymer. A plurality of sealing rings (13a-13d) that are made from a plastic material extend around the main body of the piston (10) and are materially bonded to the main body of the piston (10a). The invention furthermore relates to a medical syringe (1) and to a method for the production thereof.

A device includes an inflatable balloon, a reservoir disposed within the inflatable balloon, a needle compartment attached to the balloon and to the reservoir, an injection needle disposed within the needle compartment, and an inflation mechanism. The reservoir contains a therapeutic preparation. The inflation mechanism is structured to inflate the balloon, and upon inflation, the injection needle is structured to enter the reservoir. A method includes making an autoinjector available to a subject with instructions to ingest the autoinjector. The autoinjector is structured to inject a therapeutic preparation into a wall of a gastrointestinal tract of the subject responsive to ingestion of the autoinjector. The autoinjector includes an injection needle disposed in a needle compartment attached to a reservoir. The injection needle is initially separated from the reservoir, and is structured to enter the reservoir for delivery of the fluid therapeutic preparation through the needle into the wall.

An atomizer is disclosed. The atomizer includes: a pump housing including an internal chamber extending in an axial direction of the pump housing and a mounting seat disposed at a first end of the pump housing and being in communication with the internal chamber; a seal disposed in the mounting seat, the seal including a sealing sleeve and a first bore in the sealing sleeve and coaxial with the internal chamber, and at least a part of the seal resting against a mounting surface of the mounting seat; a pressing member at least partially disposed within the mounting seat and resting against the seal to press and keep the seal in the mounting seat, the pressing member including a second bore coaxial with the internal chamber; and a plunger, a first end of the plunger being disposed within the internal chamber of the pump housing through the second bore of the pressing member and the first bore of the seal, and the first end of the plunger being capable of reciprocating in the internal chamber to pump fluid in or out of the internal chamber; wherein the pump housing, the pressing member and the plunger together define a sealing cavity to accommodate the seal.

A system for delivering a therapeutic amount of nitric oxide can include a reservoir containing a nitrogen dioxide source. A heating element can be configured to heat the reservoir, causing nitrogen dioxide vapor to exit the reservoir through a restrictor into a conduit. The nitrogen dioxide vapor can mix with gas from a gas supply, which can then flow to a cartridge that includes a surface-activated material saturated with an aqueous solution of a reducing agent. The cartridge can convert the nitrogen dioxide into nitric oxide.

A device and a method for shaping a wire used in medical procedures, such as a guidewire used in conjunction with catheters. The device includes a body having a working face, and the body includes a wire-shaping portion, the wire-shaping portion having an aperture defined therein which extends from the working face along an aperture axis. The apertures include a flared section and a tip receiving section connected to the flared section, where the tip receiving section is shaped and sized for receiving a tip of the wire therein and maintaining a position of the tip of the wire while a bending force is exerted on the wire towards the working face. In one embodiment, the wire-shaping portion has a mound-shaped portion projecting from the working face from which the aperture extends, which enables to curve the wire in a smooth shape that follows the mound-shaped portion.

A device for catheterization is disclosed. Such a device includes a hollow catheter, a cylindrical sheath, and a flange through which the catheter passes. Before insertion, the sheath begins at a first opening near the catheter tip and extends into the catheter to a first circumferential fold, then back towards the catheter tip to a second circumferential fold about the tip to the exterior surface, and ends at a second opening attached to the flange. As the device is inserted up to a length, the flange abuts the cavity opening, and a corresponding length of the sheath deploys from the catheter interior, around the first and second circumferential folds, to the catheter outer surface. Once fully inserted, all, or a substantial portion, of the sheath initially positioned within the catheter has been deployed to the outer surface, thereby forming a protective barrier between the catheter and the surrounding tissues.

A method of manufacturing a medical device including a case having a first and a second case portion mated together. The case having a space inside and an elastic membrane attached to the case. A first housing space covered by the first case portion and a second housing space covered by the second case portion. Fixing parts at peripheries of the first and the second case portions and at which the first and the second case portions are mated. Holding surfaces at the peripheries of the first and the second case portions. A sealing part at the periphery of the first or the second ease portions with respect to the fixing parts and that seals an entirety of the peripheral edge of the elastic membrane. Forming an air gap between the sealing part and the fixing parts by depressurization or heating the fixing parts that connect the case portions.