Embodiments of an actuating device for actuating a needle cartridge and puncturing an epidermis with controlled depth. The actuating device includes a motor housed in a motor housing, an actuating rod driven by the motor and configured to actuate in a reciprocating motion, and an adjustment mechanism. The actuating rod is housed in a rod housing, the rod housing forming a device aperture configured to receive a needle cartridge and to attach to the needle cartridge. The adjustment mechanism interfaces with the rod housing and is configured to adjust a position of the rod housing relative to the motor housing while not rotating the rod housing relative to the motor housing.

Systems and methods for treating cellulite including an apparatus that applies or a method involving disrupting, stretching, re-orienting or tearing septa to eliminate or reduce the appearance of cellulite. In one approach, an expandable member is placed between tissue layers to stretch or tear septa connecting tissue layers between which fat deposits are contained.

A decubitus ulcer healing airflow device includes a motorized airflow intake fan disposed within a housing body devised to be attached to a bed rail A tubular airflow outlet is attached to a rear side of the housing body. An air filter slideably engages an access slot and is disposed between a protective grill and an airflow intake fan. At least one strap has a central elastomeric central section engageable onto the bed rail and a pair of u-shaped outer ends. Each strap engages a respective one of a pair of strap support holders disposed on each or one of a top and bottom side of the housing body. A slotted compartment, within the airflow outlet, contains a fragrance or a vaporized medicine to assist in healing the ulcers.

Applicator devices (1), kits, systems, and methods of using such devices for treating one or more body surface conditions (e.g., warts, Molluscum contagiosum, conjunctivitis, otitis) are provided. The applicator device facilitates topical administration of a controllable amount of a pharmaceutical composition to a desired area of an affected body surface (e.g., skin, eye, ear, nose, mouth, anus, vagina). The applicator device includes an ampule (40) containing the pharmaceutical composition, the ampule being positioned within a tube (50). Squeezing the tube breaks the ampule, releasing the pharmaceutical composition. The applicator device includes a filter (30) that permits passage of fluid and inhibits passage of broken ampule shards. The applicator device includes a dispensing tip (20) through which the pharmaceutical composition passes.

Systems, instruments, and methods for minimally invasive procedures including one or more of fractional resection, fractional lipectomy, fractional skin grafting, fractional scar revision, and/or fractional tattoo removal are described. Embodiments include instrumentation comprising a scalpet assembly coupled to a carrier, and the scalpet assembly includes a scalpet array. The scalpet array includes one or more scalpets configured for fractional resection, fractional lipectomy, fractional skin grafting, fractional scar revision, and/or fractional tattoo removal. The system includes a vacuum component coupled to the scalpet assembly and configured to evacuate tissue from the a site. The carrier is configured to control application of a rotational force and/or a vacuum force to the scalpet assembly.

Systems and methods for treating cellulite including an apparatus that applies or a method involving disrupting, stretching, re-orienting or tearing septa to eliminate or reduce the appearance of cellulite. In one approach, an expandable member is placed between tissue layers to stretch or tear septa connecting tissue layers between which fat deposits are contained.

This application relates to a hand-held cooling device for supplying a cryogen to a target region for cryotherapy. The device can include a cryogen container configured to contain a first cryogen having a first temperature and a nozzle configured to spray a first modified cryogen to the target region, the first modified cryogen having a second temperature higher than the first temperature. The device can also include a cryogen temperature regulator configured to receive the first cryogen and output the first modified cryogen to the nozzle, the cryogen temperature regulator disposed closer to the nozzle than the cryogen container. The cryogen temperature regulator can include a holder tube, a porous structure disposed inside a holder tube and a heater disposed around the holder tube and heating the holder tube so as to increase the first temperature to the second temperature while the first cryogen passes through the porous structure.

A cannula tubing having a series of apertures at its distal end, so that the end of the tube is not the only egress point for the payload of the cannula. The cannula tubing is affixed to a base, which is configured to accept an input connector on the end opposing the cannula. The base is configured so that input medication from the connector flows down the cannula. The base is affixed to the patient via adhesive. The perforated cannula distributes the dose of the medication across a wider area. This has been demonstrated to increase uptake rate of some medications (reducing the time to peak absorption rate). Administering medication (such as insulin) over a greater area may lessen unwanted side effects of subcutaneous injecting, such as lipohypertrophy, scarring, or localized drug resistance.

A combination product comprising a nasal spray dispenser containing a formulation for nasal administration, and a balm holder element containing a skin-care balm, attached to a bottom of the nasal spray dispenser.

A soft tip applicator attaches to a syringe for spreading expressed liquid from the syringe onto a surface, such as skin. A detachable hollow microneedle assembly supports transdermal injection of syringe contents.