A method for the long-term delivery of fluids to a bone of a patient includes providing a cannulated bone screw and an insert configured to be coupled to the bone screw. The method further includes creating an aperture in the skin of a patient, inserting the bone screw into a bone of the patient through the aperture, and coupling the insert to the bone screw. The method further includes the steps of providing a fluid source, coupling the fluid source to the insert, and delivering a fluid from the fluid source to the insert.

Intranodal needle and method of using the same. The present disclosure includes disclosure of a method, comprising inserting a tip of a needle through the skin and into a tissue selected from the group consisting of a lymph node and a thoracic duct, and delivering an immune modulating agent through the needle and into the tissue to treat at least one immune disorder.

A method for the long-term delivery of fluids to a bone of a patient includes providing a cannulated bone screw and an insert configured to be coupled to the bone screw. The method further includes creating an aperture in the skin of a patient, inserting the bone screw into a bone of the patient through the aperture, and coupling the insert to the bone screw. The method further includes the steps of providing a fluid source, coupling the fluid source to the insert, and delivering a fluid from the fluid source to the insert.

A system for the treatment of Alzheimer's disease is provided by moving cerebrospinal fluid containing particles know to contribute to onset of Alzheimer's disease from a source of cerebrospinal fluid to the stomach or bladder, where the particles are safely digested by gastric acid or excreted, the system including an implantable pump, an inlet catheter, an outlet catheter, and a one-way valve. The system further includes at least one filter to filter harmful particles from the cerebrospinal fluid and return the filtered cerebrospinal fluid back to the source of cerebrospinal fluid, where the harmful particles blocked by the filter may be rinsed off the filter and transported to the stomach or bladder.

A vehicle including a plurality of interior panels that include an outer decorative layer formed of a material that includes a thermochromic coloring agent. A physiologic condition monitoring device monitors various physiologic conditions of a driver of the vehicle, and based on the physiologic conditions of the driver, a temperature of the thermochromic coloring agent can be changed to change a first color of the thermochromic coloring agent to a second and different color to influence the physiologic condition of the driver.

A kit is provided for performing an ultrasound-guided transversus abdominis plane (TAP) procedure. The kit includes a container having a fluid delivery needle with a length and gauge for penetration into a patient's TAP. An extension set is included having a distal end that mates with the fluid delivery needle. A sheath is included having a size and length such that the needle slides into sheath and extends distally beyond a distal end of the sheath. A TAP catheter is included having a size and length so as to slide through the sheath. The TAP catheter has a reservoir with a defined fill volume and flow rate for delivery of a local anesthetic through said catheter.

A tubing assembly for use with an electronic catheter guidance systems is provided and includes a catheter and a stimulation electrode assembly, and an electrical connection for delivering a stimulation waveform to the stimulation electrode assembly. The catheter extends in a longitudinal direction and has a proximal end and a distal end that define a lumen therebetween. Further, the catheter is configured for placement within a patient's digestive tract. The stimulation electrode assembly is configured to deliver an electrical stimulation to tissue. A catheter guidance system and method for accurately placing a catheter in the digestive tract are also provided.

A method for improving the ultrasonic transdermal delivery of an drug by modifying the excipient solution to which an active ingredient is intermixed in a drug formulation, whereby the choice of excipient solution is modified to one which will be more conducive to ultrasound and will propagate the drug substance at a higher delivery speed through the skin under ultrasonic excitation An example of such an excipient change includes a conversion from a standard dibasic sodium phosphate containing formulation to one using far less sodium or less preservative compositions. Reduced dibasic sodium phosphate formulation. Responsively to insonification thereof, including: reducing the amount of dibasic sodium phosphate in the formulation to provide a reduced dibasic sodium phosphate formulation; and, making a substance in accordance with the reduced dibasic sodium phosphate formulation.

A sleep control system in accordance with an embodiment of the present invention includes: a heating section being provided in contact with a human body and heating the human body; and a control section for controlling a heating operation carried out by the heating section, the heating section carrying out heating at a temperature in a range of 36 C. to 41 C. in a period from time for starting heating until a scheduled awakening time, the time for staring heating being in a period of 90 minutes to 150 minutes prior to the scheduled awakening time, and the heating section carrying out no heating at a temperature higher than 33 C. in a period from bedtime until the time for starting heating or in a period after elapse of a given time from the bedtime and until the time for starting heating.

Bone bypass shunts and methods using thereof. Method for affecting a pathophysiological condition in a body of a live subject includes exemplary steps/procedures of: connecting an inlet port of a bone bypass shunt to a first bone portion adjacent a first bone marrow location such that inlet port lumen of inlet port facilitates fluid communication with blood accumulated or flowing at first blood marrow location; connecting outlet port of the bone bypass shunt to second bone portion adjacent second bone marrow location, such that outlet port lumen of outlet port facilitates fluid communication with bone marrow; a formed cavity, or/and bone marrow vasculature, located at second bone marrow location; via inlet port lumen, removing a chosen volume of blood from first bone marrow location; and via outlet port lumen, delivering chosen volume of blood to the second bone marrow location.