A respiratory therapy apparatus is operable to deliver multiple types of therapy to a patient. The apparatus includes a main housing and a nebulizer tray that selectively attaches to a bottom of the main housing. The apparatus also includes a filter housing unit having an antenna surrounding a pneumatic passage and a transponder chip coupled to the antenna. The main housing has also has an antenna that surrounds a respective pneumatic passage of a main outlet port of the apparatus. The main housing includes a reader that controls communication between the antennae. The main housing of the apparatus also has a pivotable hose support plate, a firmware upgrade port underneath part of the top wall of the housing, and a graphical user interface (GUI) that displays various user inputs for control of the apparatus and that displays various alert conditions that are detected.

A system for calculating cardiac output (CO) of a patient undergoing veno-arterial extracorporeal oxygenation includes measuring first oxygenated blood flow rate by a pump in the extracorporeal blood oxygenation circuit as introduced into an arterial portion of the patient circulation system and a corresponding arterial oxygen saturation, then changing the pump flow rate, such as decreasing, to produce a corresponding change in arterial oxygen saturation (wherein such change is outside of normal operating variances, operating errors or drift), which change in the arterial oxygen saturation is measured. From the first flow rate and the second flow rate along with the corresponding measured arterial oxygen saturation, the CO of the patient can be calculated, without reliance upon a measure of venous oxygen saturation. Alternatively, the CO of the patient can be calculated, without reliance upon a change in flow rate by changing a gas exchange with the blood in the extracorporeal blood oxygenation circuit to impart corresponding changes in a blood parameter in the arterial portion of the patient circulation system and the blood delivered from the extracorporeal blood oxygenation circuit.

A catheter system may include a catheter lumen, first and second electrodes, and a sensor in communication with the first and second electrodes. The sensor may be configured to detect at least one of: a bulk volume of blood within a blood vessel and extravasation of a drug from the blood vessel into soft tissue adjacent the blood vessel. Other catheter systems may include a catheter lumen and a sensing chip coupled to the catheter lumen. The sensing chip may be configured to detect at least one of: a bulk volume of blood within a blood vessel and extravasation of a drug from the blood vessel into soft tissue adjacent the blood vessel.

A system for carbon dioxide (CO2) removal from a circulatory system of a patient includes a medical device providing extracorporeal lung assist (ECLA) treatment to the patient through extracorporeal removal of CO2 from the patient's blood; at least one control unit controlling the operation of the medical device so as to control a degree of CO2 removal obtained by the ECLA treatment; and a bioelectric sensor detecting a bioelectric signal indicative of the patient's efforts to breathe. The at least one control unit is configured to control the operation of the medical device based on the detected bioelectric signal.

In one embodiment, an infusion set and sensor assembly delivered within a subject is disclosed. The assembly includes a cannula that is terminated at a cannula opening. The assembly further includes a sharp that is at least partially within the hollow of the cannula. A sensor having a proximal end and a distal end is also included in the assembly. The proximal end of the sensor is held in a fixed location while the distal end is retained with a portion of the cannula. The sensor further includes sensor slack, wherein transitioning the sharp from a first position to a second position simultaneously inserts the cannula and sensor to a desired insertion depth within a subject via a single point of insertion.

A monitoring device for monitoring a hypocortiolism patient, the monitoring device comprising:a needle for penetrating a skin of the patient, andan analysis module fluidly connected with the needle, the analysis module comprising: o a first sensor, for measuring an inflammation level representative for the patient; and/or o a second sensor, for measuring a stress level representative for the patient; and wherein the monitoring device is configured to automatically trigger a notification in response to the first sensor measuring an inflammation level exceeding a first pre-defined threshold and/or in response to the second sensor measuring a stress level exceeding a second pre-defined threshold.

The present disclosure relates to a control device or closed-loop control device programmed to control or regulate a blood treatment apparatus during an administered treatment of a patient's blood using an extracorporeal blood tubing set and the blood treatment apparatus based on set adjustable values of treatment parameters set by using the blood treatment apparatus or using another device optionally connected to the extracorporeal blood tubing set, wherein the control device or closed-loop control device is further programmed, after reading, to compare at least one measurement value collected during the administered treatment, as the actual value of a blood parameter with a stored target value of the blood parameter. Based on this comparison and observation of a set adjustable value of one of the treatment parameters, either a correction value or correction factor to change the set adjustable value or a new adjustable value is determined in each case.

Disclosed herein are methods, systems, and devices for controlling a gas mixture within a mechanical ventilator. According to one embodiment, a computer implemented method includes receiving first peripheral arterial oxygen saturation (SpO.sub.2) data from a pulse oximeter via a pulse oximeter interface, wherein the pulse oximeter is configured to monitor a patient receiving invasive ventilation; determining a first mode of operation for a ventilator mechanism, wherein the ventilator mechanism is configured to provide at least a portion of the invasive ventilation; determining first partial pressure of oxygen (PaO.sub.2) data stored in a first lookup table using the first SpO.sub.2 data, wherein the first lookup table is derived from a sigmoid shaped oxyhemoglobin dissociation curve; determining first fraction of inspired oxygen in air (FiO.sub.2) data for setting a mixture in a gas blender in the ventilator mechanism based on the first PaO.sub.2 data and a variable offset; and providing the FiO.sub.2 data to the ventilator mechanism.

A modified hemofiltration method for clearing peripheral α-synuclein aggregates in patients with neurodegenerative diseases is provided, which falls into the field of medicine. Specifically, a ratio S of synuclein dimers in blood is obtained; a blood flow velocity and an exchange membrane area for hemofiltration are determined through clinical trial data or historical literature data; hemofiltration is performed by the determined blood flow velocity and exchange membrane area, a calculation model of the ratio S of different synuclein dimers and an exchange membrane aperture D required for hemofiltration is constructed by linear regression; a clearance rate of synuclein dimers can be estimated by setting hemofiltration parameters with the calculation model. It is found that hemofiltration is beneficial to reducing the level of peripheral α-synuclein aggregates in patients with neurodegenerative diseases. Therefore, the calculation model is constructed, which provides scientific data and a new solution for clinically relieving α-synuclein-related toxicity symptoms.

Systems and methods for treating a medical condition such as worsening heart failure (WHF) are described. A medical system may sense one or more physiological signals, and generate from the sensed physiological signals a signal metric trend indicating a progression of heart failure. A detector may detect a physiological event leading to WHF. A therapy control circuit may generate a therapy titration protocol using the generated signal metric trend. The therapy titration protocol includes a temporal profile of therapy dosage relative to a target dosage. The therapy control circuit may adjust the target dosage based on patient response. Therapies may be administered by a clinician or automatically delivered to the patient according to the therapy titration protocol.