Stimulation of nervous system components by electrodes can be used in many applications, including in the operation of brain-machine interfaces, bidirectional neural interfaces, and neuroprosthetics. The optimal operation of such systems requires a means of accurately measuring neural responses to such stimulations. However, currently the measurement of neural responses is difficult due to heavy stimulation artifacts arising from stimulatory pulses. The invention encompasses novel methods of estimating stimulation artifacts in measurements attained by recording electrodes and the effective removal of these artifacts. This provides improved neural recording systems and enables the deployment of closed-loop neural stimulation systems.

In embodiments, a wearable cardioverter defibrillator (WCD) system includes a support structure for wearing by an ambulatory patient. When worn, the support structure maintains electrodes on the patient's body. Different pairs of these electrodes define different channels, and different patient ECG signals can be sensed from the channels. The ECG signals can be analyzed to determine which one is the best to use, for the WCD system to make a shock/no shock decision. The analysis can be according to widths of the QRS complexes, consistency of the QRS complexes, or heart rate agreement statistics.

Described herein are high-power pulsed electromagnetic field (PEMF) applicator apparatuses. These apparatuses are configured to drive multiple applicators to concurrently deliver high-power PEMF signals to tissue. The apparatuses may be further configured to wirelessly communicate with local computing device and a remote server for patient monitoring, prescription and/or device servicing.

The present invention relates to a multi-target electrical stimulation circuit, an electrical stimulator, and a signal output method of the electrical stimulator. The electrical stimulation circuit includes a control module, a plurality of brain wave acquisition modules and a plurality of stimulation adjustment modules. Each electrode is correspondingly provided with one brain wave acquisition module and one stimulation adjustment module, and different electrodes are used for stimulating different targets. The brain wave acquisition modules are used for acquiring brain wave signals in the corresponding electrodes and transmitting the brain wave signals to the control module. The control module is used for acquiring brain rhythm phase signals according to the received brain wave signals and outputting stimulation signals at preset waveform phase points after phase locking of the brain rhythm phase signals. The stimulation adjustment modules are used for adjusting brain wave stimulation signals output to the corresponding electrodes according to the received stimulation signals. The multi-target electrical stimulation circuit, the electrical stimulator and the signal output method provided by the present invention are beneficial for achieving electrical stimulation of a plurality of targets as well as time-locked matching of electrical stimulation of a plurality of targets.

A cochlear implant system for processing polyphonic pitch includes an electrode array for implanting in a cochlea of a patient. The electrode array includes a first set of electrodes, where each electrode of the first set is for implanting on a first region of the cochlea. The electrode array also includes a second set of electrodes, where each electrode of the second set is for implanting on a second region of the cochlea. The system also includes a sound processor configured to capture a sound signal having polyphonic pitch. For each electrode of the first set and second set, the speech processor generates at least two different modulated frequency signals from the sound signal, such that each of the modulated frequency signals corresponds to a different pitch in the sound signal. The speech processor stimulates the electrode by simultaneously applying the at least two different modulated frequency signals.

A transcutaneous neurostimulation therapy system can include an electrostimulation electronics unit, including first and second neurostimulation output which can be respectively coupled to first and second neurostimulation skin electrodes, and the electrostimulation electronics unit can include or be coupled to a rechargeable battery. The transcutaneous neurostimulation therapy system can also include battery charging circuitry configured for being coupled via the first and second neurostimulation output terminals to the electrostimulation electronics unit for charging the battery of the electrostimulation electronics unit through the first and second neurostimulation skin electrodes.

The present invention relates to a pulsed radio frequency therapy system adapted to project the beam onto the skin surface of a living body overlying a problem region, the beam serving to relieve pain and to obtain other health related beneficial effects. The system includes an energy-generating unit in which a radio-frequency carrier is over-modulated by a sonic signal to produce periodic bursts of radio-frequency energy whose repetition rate corresponds to the frequency of the signal. The output of the unit is fed to a tank circuit tuned to the carrier frequency and housed within the barrel of a portable applicator gun. Supported within the barrel and coupled to the tank circuit is a discharge electrode whose tip is adjacent to the mouth of the barrel whereby a pulsed radio frequency is projected from the tip. The portable applicator gun includes automated applicator coil tuning, automated coil protection, and a phase-up conditioning system. The energy generating unit includes a lifespan sensing system which includes a modem, a GPS, and a transceiver so that the pulsed radio frequency therapy system may transfer and/or receive information wirelessly to an external storage and/or processing area which tracks the usage, wear and tear, location, and other treatment data of the user and the therapy system.

A tremor-reduction system is provided that delivers electric current to a body region of a subject that is associated with a tremor. A computing device stores received data associated with a tremulous movement of the body region and determines measurements associated with the stored data. If a magnitude of the most recent tremulous movement is the same as or greater than magnitudes associated with prior tremulous movements, characteristics of a subsequent electric current to be applied to the body region may be adjusted.

An example of a system for programming neurostimulation according to a stimulation configuration may include stimulation configuration circuitry, volume definition circuitry, stimulation effect circuitry, and recording circuitry. The stimulation configuration circuitry may be configured to determine the stimulation configuration. The volume definition circuitry may be configured to determine stimulation field model(s) (SFM(s)) each representing a volume of tissue activated by the neurostimulation. The stimulation effect circuitry may be configured to determine a stimulation effect type for each tagging point specified for the SFM(s) and to tag the SFM(s) at each tagging point with the stimulation effect type determined for that tagging point. The stimulation effect type for each tagging point is a type of stimulation resulting from the neurostimulation as measured at that tagging point. The recording circuitry may be configured to generate SFM data representing the determined SFM(s) with the stimulation effect type tagged at each tagging point.

Methods and apparatuses for monitoring and regulating physiological states and functions are disclosed. Several embodiments include application of one or more microelectrode arrays to a dorsal root ganglion for measurement of sensory neuron activity, or stimulation of sensory reflex circuits. The methods and apparatuses can be used, for example, for monitoring or controlling bladder function in a patient.