A photonic integrated circuit, PIC, comprising a plurality of semiconductor layers on a substrate, the plurality of semiconductor layers forming a PIN or PN doping structure, the PIC comprising a waveguide arranged for conducting light waves; an optical element connected to the waveguide, wherein the optical element, in operation, is in reverse-bias mode, and wherein the optical element comprises a contact layer arranged for connecting to a voltage source; wherein the waveguide comprises conducting contacts proximal to the optical element, and wherein the PIC further comprises at least one isolation section arranged in between the optical element and the conducting contacts. Corresponding methods of operation of such a PIC are also presented herein.

A therapeutic method of reducing or eliminating viral infections in vivo includes subjecting a virally infected patient to one of a variety of strong magnetic fields. A static magnetic field has a magnetic field intensity of at least about 5 nanoTesla sufficient to be effective to disrupt viral metabolism. An alternating magnetic field has a magnetic field intensity of at least 0.1 nanoTesla sufficient to be effective to disrupt viral metabolism. A method of disrupting viral metabolism includes subjecting an infected patient or a mixture of live host cells and virus to the alternating magnetic field. A virus disruption apparatus includes a magnetic field generator of static or alternating magnetic fields. The magnetic field generator is selected from a Magnetic Resonance Imaging device, at least one permanent magnet, at least one superconducting magnet, at least one solenoid, and any combination thereof.

Systems and methods for clinical neuronavigation in accordance with embodiments of the invention are illustrated. One embodiment includes a method for generating a brain stimulation target, including obtaining functional magnetic resonance imaging (fMRI) image data of a patient's brain, were brain imaging data describes neuronal activations within the patient's brain, determining a brain stimulation target by mapping at least one region of interest to the patient's brain, locating functional subregions within the at least one region of interest based on the fMRI image data, determining functional relationships between at least two brain regions of interest, generating parameters for each functional subregion, generating a target quality score for each functional subregion based on the parameters and selecting a brain stimulation target based on its target quality score and the patient's neurological condition.

This invention relates to methods and systems for removing plaque from arteries and blood vessels in human subjects non-invasively utilizing coated superparamagnetic nanoparticles introduced into the human bloodstream and controlled by external magnetic fields to effect plaque removal. Magnetic nanoparticles are injected into a patient, and magnetic fields are used to move the nanoparticles to the site of an arterial blockage. The nanoparticles are then oscillated by means of an alternating current source and oscillating magnetic field. The nanoparticles impact the plaque deposit, causing it to break up, so that it may be safely disintegrated, dissolved in the bloodstream, digested by enzymes or ions and/or removed with the nanoparticles themselves. The nanoparticles are removed by a unipolar magnetic field directing them to be removed at the point of injection or alternative location in the body. The nanoparticles are also removed by natural bodily functions. The methods and systems are directed to the emergency clearance of arteries in the human body, and the routine annual and quarterly clearance and preventative maintenance of arteries in the human body.

A system is provided for increasing skin rejuvenation of a region of a patient's skin comprising a pulsed electromagnetic field (PEMF) frequency generator for constantly providing electromagnetic pulses to said region of a patient's skin and a deep tissue diathermy device for constantly applying heat to said region of a patient's skin up to temperature T. The system is adapted for simultaneously applying heat and PEMF to the region of a patient's skin. Application of the system increases skin rejuvenation such that the skin rejuvenation increase (SRI) is greater than the sum of the SRI provided by electromagnetic pulses increase and the SRI provided by the deep tissue diathermy device increase.

The present invention relates to a brain stimulating device and, particularly, relates to a brain stimulating device comprising: a brainwave measurement unit for outputting a brainwave signal; and a stimulation unit for applying spindle-like stimulation to a brain in accordance with the generation of slow oscillation included in the brainwave signal. The brain stimulating device according to the present invention can reinforce memory or reduce memory deterioration due to dementia. Also, the brain stimulating device according to the present invention can reinforce hippocampus-dependent memory. Further, a portable device according to the present invention can control and monitor the brain stimulating device. Moreover, a method for assessing the performance of the brain stimulating device according to the present invention can assess the performance of the brain stimulating device.

The disclosure provides methods of cancer treatment and apparatus and, more particularly, to non-invasive cancer treatments utilizing oscillating magnetic fields to disrupt mitochondrial function or induce apoptosis or another mechanism of cell death in cancer cells. The disclosure also provides a device for providing an OMF treatment to a subject.

Proposed is a beauty care method of enhancing a skin defense function, in which a wave at a Schumann resonance frequency is applied to a cell. A method of facilitating expression of an antibacterial peptide and a method of facilitating expression of sirtuin 1 are also proposed, in each of which a wave at a Schumann resonance frequency is applied to a cell. Furthermore, an apparatus for facilitating expression of an antibacterial peptide and an apparatus for facilitating expression of sirtuin 1 are proposed, each of which includes an electromagnetic wave generation unit configured to generate a wave at a Schumann resonance frequency, and in each of which the wave at the Schumann resonance frequency is applied to a cell.

An electromagnetic field generating apparatus for treating pathological cells, in particular with tumor suppression function. The ratio of static magnetic field to alternating magnetic field is in the range of 0.5-2.5, and the total intensity is in the range up to 100 mT. It provides non-invasive low toxicity and side effects, significantly inhibiting a plurality of tumors, influencing the intracellular superoxide radical content, and promoting cell autophagy. The mechanism of action of the magnetic field is on the electron spin energy levels and consequently on free radical concentration. Additional magnetic field having frequency up to 100 MHz and intensity down to microTesla range can be also used to improve the antitumor efficacy in combination with the static as well as the extremely low frequency electromagnetic field (1-300 Hz) influencing the spin hyperfine resonance. A combination method is also provided of a power-frequency electromagnetic field generating device and a platinum-based medicine.

An apparatus for proliferation of organic tissue by exposure to electromagnetic field is disclosed that comprises an electromagnetic patch 101 comprising one or a plurality of electromagnetic coils 103 each generating an electromagnetic field; and a battery powered drive unit 102 which supplies signals to the electromagnetic coils for applying a particular dosage of electromagnetic field to a target tissue region. The electromagnetic patch 101 is specifically customised to an individual subject user and to an individual body portion and tissue region of said individual user. The drive signal sequence is individually tailored to the electromagnetic patch for delivering a particular dosage programme of electromagnetic field for the particular subject user.