A hyperthermia implant 20 for hyperthermia treatment of tissue 30 of a human or animal body. The implant comprises at least one piece of a large Barkhausen jump material (LBJ) and a magnetic field may be applied to the implant to heat the surrounding tissue. The implant may also be deployed to mark a tissue site in the body for subsequent surgery, thereby providing a combined system for locating an implant and treating the surrounding area. The system includes a handheld probe 14 to excite the implant below the switching field for bistable switching causing a harmonic response to be generated in a sub-bistable mode that allows the implant to be detected and localised.

Systems, methods, and computer-readable media for enabling ultraviolet radiation treatments are provided.

A magnetic field emitter (100) for emitting a magnetic field into an environment having a rotatable magnetic member (102) comprising one or more magnetic dipoles; a support (104) for the rotatable magnetic member (102), wherein the support (104) is configured to be placed in a support position on a surface of the environment such that when the support (104) is in the support position the one or more magnetic dipoles of the rotatable magnetic member (102) lie in a substantially horizontal plane; and a rotation mechanism (106) operable to rotate the rotatable magnetic member (102) relative to the support (104) about a rotation axis, such that when the support (104) is placed in the support position on the surface, the rotation axis is substantially orthogonal to said substantially horizontal plane such that the substantially horizontal plane remains substantially horizontal during the rotation.

The present invention relates to a method and apparatus for simulating the vagus nerve. The apparatus for stimulating the vagus nerve includes: a magnetic field generation unit generating a magnetic field in a form of pulse, which stimulates a preset area including the vagus nerve of a user by an electric current applied to a coil; a power supply unit applying the electric current to the coil; and a control unit controlling an intensity of the electric current applied to the coil, and a pulse width and a peak interval of the magnetic field, wherein the magnetic field has a peak intensity that is set using a biomagnetic signal of the use. According to the present invention, the body function may be improved using the pulsed magnetic field with the intensity close to the biomagnetic signals.

Provided are systems and methods for decalcifying aortic valves and/or other valves, blood vessels, and/or cardiac tissues in a mammalian (e.g., a human) patient (e.g., a patient having or suspected of having calcific aortic valve disease (CAVD)). A transcatheter (aortic) valve decalcification system/method can include applying one or more pulsed magnetic fields to the calcium deposit(s) within a valve or other vessel or tissue within the patient. The system can include a catheter having pulsed magnetic field ribbons disposed therein, and the catheter can be provided to the patient.

A method of treatment includes using an electrical energizing source coupled to a current conducting coil to cause the current conducting coil to produce pulsed electromagnetic fields. A conducting membrane is placed adjacent the current conducting coil and an insulating coupling interface is placed adjacent the membrane, such that the membrane is between the current conducting coil and the insulating coupling interface. One portion of the pulsed electromagnetic fields is intercepted by the membrane so that the membrane oscillates to generate acoustic waves to tissue adjacent the insulating coupling interface and another portion of the pulsed electromagnetic fields propagates through the insulating coupling interface to the tissue.

The disclosure describes devices and methods for providing transdermal electrical stimulation therapy to a subject including positioning a stimulator electrode over a glabrous skin surface overlying a palm of the subject and delivering electrical stimulation via a pulse generator transdermally through the glabrous skin surface and to a target nerve or tissue within the hand to stimulate the target nerve or tissue within the hand so that pain felt by the subject is mitigated. The pulses generated during the electrical stimulation therapy may include pulses of two different magnitudes.

Systems and method for destroying or inhibiting cancer cells and other rapidly-dividing cells include applying AP magnetic fields having a defined frequency of 5 Hz-500 kHz and a field strength of 0.1-5000 μT to a target body area that includes the cancer or other rapidly-dividing cells, and modifying the cancer or tumor microenvironment to increase the presence of cancer-suppressive cells or decrease the presence of cancer-promoting cells. In various embodiments, the systems and methods may include adjusting the therapy based on the dosage of an immunotherapy drug administered to the patient before, during, or after the application of the AP magnetic fields.

Methods for inducing cell death by magneto-endosomalytic therapy using magnetic nano articles. The methods include inducing cell death, inducing cell death in a subject, and application of the methods to killing tumor cells in a subject.

An assay device and method of assaying the application of energy to a plurality of samples in vitro. The assay device includes a housing, an array, and a control module. The housing includes a socket sized to receive a culture plate. The array includes a plurality of emitters and is positioned within the housing adjacent to the socket so that the plurality of emitters are each aligned with at least one culture well of the culture plate when the culture plate is received in the socket. The control module is operably coupled to the array and is configured to individually drive the plurality of emitters. The control module is configured to drive at least two of the plurality of emitters at different frequencies simultaneously.