Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

The invention relates to an antenna device configured to superimpose a plurality of electromagnetic modes in the near field, with a multilayer structure comprising, in a vertical stacking direction: a first power supply layer comprising a first dielectric on an application-specific integrated circuit and on a lower part of a DC power supply circuit, a second power supply layer comprising an upper part of a DC power supply circuit, a third layer comprising a second dielectric on a metal plane, a fourth layer comprising at least one planar radiating element, the metal plane acting as a grounding plane, a fifth layer comprising a radome, the antenna device comprising at least one feed line extending from the first to the fourth layer.

The invention relates to an antenna device configured to superimpose a plurality of electromagnetic modes in the near field, with a multilayer structure comprising, in a vertical stacking direction: a first power supply layer comprising a first dielectric on an application-specific integrated circuit and on a lower part of a DC power supply circuit, a second power supply layer comprising an upper part of a DC power supply circuit, a third layer comprising a second dielectric on a metal plane, a fourth layer comprising at least one planar radiating element, the metal plane acting as a grounding plane, a fifth layer comprising a radome, the antenna device comprising at least one feed line extending from the first to the fourth layer.

Provided is a device for microwave hyperthermia that may attach a flexible patch on the skin of a user based on a cross-section of a body tissue of the user, for example, a joint and muscle of a leg and an arm and may emit microwaves towards a plurality of points of the body tissue through the patch. The microwaves emitted toward the body tissue may have the same phase and maximum power. Accordingly, a maximum heat generation point may be generated in an area adjacent to the plurality of points. The device for microwave hyperthermia may move the maximum heat generation point by sequentially changing a phase and a direction of each of the microwaves. The device for microwave hyperthermia may uniformly distribute and maintain heat for treating pain and/or infection over the entire cross-section or a partial area. The device for microwave hyperthermia may be portable.

Methods for treating urinary stress incontinence by non-invasively delivering energy to one or more submucosal regions of vaginal tissue to induce remodeling within the vaginal tissue are provided. In some embodiments, the energy delivery results in heating of the target tissue to a temperature that ranges from about 38° C. to about 46° C. In some embodiments, the subject methods involve cooling a mucosal epithelial layer over the vaginal tissue. In some embodiments, a reverse thermal gradient is produced as the mucosal epithelium is cooled while energy is delivered to the underlying vaginal tissue.

A system includes, first and second circuitries and one or more devices. The first circuitry is configured to generate a stress signal for reducing an impedance of tissue of an organ. The second circuitry is configured to generate an irreversible electroporation (IRE) signal for producing a lesion in the tissue. The one or more devices are configured to apply to the tissue, the stress signal at a first time interval, and the IRE signal at a second time interval, subsequent to the first time interval.

A hemodynamic parameter (Hdp) monitoring system for diagnosing a health condition of a patient and for establishing Hdp marker values or Hdp surrogate marker values for purposes of comparison with Hdp values of a patient is provided. An Hdp monitor senses, measures, and records Hdp values exhibited by the patient during a basal or non-exposure period and furthermore Hdp values exhibited by the patient during or after an exposure period during which the patient is exposed to low-energy electromagnetic output signals. An electrically-powered generator is adapted to be actuated to generate said low-energy electromagnetic carrier output signals for exposing or applying to the patient such output signals during said exposure period.

There is disclosed a method of treating affected external or surface tissue comprising the steps of providing a source of affected external or surface tissue; generating a source of microwave energy; transmitting said microwave energy into said affected external or surface tissues; exposing said affected external and surface tissues to said microwave energy to raise the local temperature to thereby ablate, remove, coagulate or otherwise alter said affected external and surface tissues. There is also disclosed an apparatus for the treatment of affected external and surface tissues comprising a microwave energy source generator, a means to transmit said microwave energy into said affected external or surface tissues, a means to control the exposure of said affected external and surface tissues to said microwave energy to raise the local temperature to thereby ablate, remove, coagulate or otherwise alter said affected external and surface tissues; and optionally a means to control the repetition of steps a) to d) multiple times until the ablation, removal, coagulation or otherwise alteration is complete, the period between each sequence of steps a) to d) being optionally cooled, and the location of said concentrated electric field being varied.

The invention relates to a device (10) comprising at least one housing (2) having a heat source (1), and at least one strand (11, 12) forming a more flexible pad than the housing (2). The strand (11, 12) comprises two layers (14, 19) of heat-conducting material and a layer (18) of phase change material situated between the two layers of heat-conducting material.