A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. The operations further include prescribing a dose rate and optimizing dose rate constraints for FLASH therapy, and displaying a dose rate map of the FLASH therapy.

The invention provides for a medical apparatus (100, 300, 400) comprising a subject support (102) configured for moving a subject (106) from a first position (124) to a second position (130) along a linear path (134). The subject support comprises a support surface (108) for receiving the subject. The subject support is further configured for positioning the subject support in at least one intermediate position (128). The subject support is configured for measuring a displacement (132) along the linear path between the first position and the at least one intermediate position. Each of the at least one intermediate position is located between the first position and the second position. The medical apparatus further comprises a camera (110) configured for imaging the support surface in the first position. Execution of machine executable instructions 116 cause the a processor (116) controlling the medical apparatus to: acquire (200) an initial image (142) with the camera when the subject support is in the first position; control (202) the subject support to move the subject support from the first position to the second position; acquire (204) at least one intermediate image (144) with the camera and the displacement for each of the at least one intermediate image as the subject support is moved from the first position to the second position; and calculate (206) a height profile (150, 600, 604) of the subject by comparing the initial image and the at least one intermediate image. The height profile is at least partially calculated using the displacement. The height profile is descriptive of the spatially dependent height of the subject above the support surface.

A lung phantom unit for radiotherapy according to an embodiment of the present disclosure may arrange, at a location not affected by a magnetic field, a phantom driving cylinder and a driving device which may move a lung mimic and a tumor mimic in a lung simulation block. The lung phantom unit may be used for general purpose even as a phantom for MRI-based and CT image-based radiotherapy. Since lung and tumor motions are implemented by air injection, it may be possible to precisely measure the motion and volume change of a lung according to subtle changes in air pressure so that customized radiotherapy suitable for a patient having various breathing patterns is possible.

A lung phantom unit for radiotherapy according to an embodiment of the present disclosure may arrange, at a location not affected by a magnetic field, a phantom driving cylinder and a driving device which may move a lung mimic and a tumor mimic in a lung simulation block. The lung phantom unit may be used for general purpose even as a phantom for MRI-based and CT image-based radiotherapy. Since lung and tumor motions are implemented by air injection, it may be possible to precisely measure the motion and volume change of a lung according to subtle changes in air pressure so that customized radiotherapy suitable for a patient having various breathing patterns is possible.

Apparatuses (devices, systems) and methods for shielding (protecting) surroundings around periphery of regions of interest located inside objects (e.g., patients) from radiation emitted by X-ray systems towards the objects. Apparatus includes: at least one radiation shield assembly including a support base connectable to an X-ray system radiation source or detector, and a plurality of radiation shield segments sequentially positioned relative to the support base, thereby forming a contiguous radiopaque screen configured for spanning around the region of interest periphery with a radiopaque screen edge opposing the object. Radiation shield segments are individually, actively controllable to extend or contract to selected lengths with respective free ends in directions away from or towards the support base(s), for locally changing contour of the radiopaque screen edge. Applicable for shielding (protecting) medical personnel, and patients, from exposure to X-ray radiation during medical interventions or/and diagnostics.

Disclosed is a bore based medical system comprising a camera carrier configured to be mounted in the bore based medical system and configured to monitor and/or track patient motion within said bore based medical system during radiotherapy, the bore based medical system comprising a rotatable ring-gantry configured to emit a radiotherapy beam focused at an iso-center of the bore based medical system, wherein the ring-gantry is configured to rotate at least partly around a through-going bore having a front side and a back side, configured to receive from said front side, a movable couch configured to be moved into and out from the through-going bore, wherein further the through-going bore comprises an inner side facing an inside of the bore, and wherein the camera carrier is configured to be mounted inside the bore in connection with the inner side of the through-going bore.

A magnetic resonance (MR)-radiotherapy (RT) hybrid system for treating a patient is disclosed. The MR-RT hybrid system comprises: an MR imaging (MRI) apparatus comprising bi-planar magnets configured to generate a magnetic field; a radiation source configured to supply a radiation beam to treat the patient; a gantry configured to couple the MR apparatus at a first end and the radiation source so that they can rotate in unison; a treatment support configured to support the patient; a motor configured to move the treatment support; and a controller. The controller comprises a processor and memory having stored thereon instructions, which when executed by the processor, cause the motor to move the treatment support in order to avoid collision between the MRI apparatus and the patient when the MRI apparatus is rotated. A method for positioning the treatment support within the MR-RT hybrid system is also disclosed.

Disclosed herein, inter alia, are methods of use and composition of novel inhibitors that target the Smac binding site of a variety of inhibitor of apoptosis proteins that contain a Bir domain, including XIAP, cIAP1, cIAP2, or other IAP proteins.

Disclosed herein are systems and methods for identifying radiation therapy treatment data for patients. A processor accesses a neural network trained based on a first set of data generated from characteristic values of a first set of patients that received treatment at one or more first radiotherapy machines. The processor executes the neural network using a second set of data comprising characteristic values of a second set of patients receiving treatment at one or more second radiotherapy machines. The processor executes a calibration model using an output of the neural network based on the second set of data to output a calibration value. The processor executes the neural network using a set of characteristics of a first patient to output a first confidence score associated with a first treatment attribute. The processor then adjusts the first confidence score according to the calibration value to predict the first treatment attribute.

In a radiation therapy system, treatment X-rays are delivered to a target volume at the same time that imaging X-rays are also delivered to the target volume for generating image data of the target volume. That is, during an imaging interval in which imaging X-rays are delivered to the target volume, one or more pulses of treatment X-rays are also delivered to the target volume. In each pixel of an X-ray imaging device of the radiation therapy system, image signal is accumulated during portions of the imaging interval in which only imaging X-rays are delivered to the target volume and is prevented from accumulating in each pixel during the pulses of treatment X-rays.