The combination of skin-contacted stimulation together with capillary blood flow monitoring is applied in a tandem, coordinated fashion in an integrated system and method to provide early detection of compromised circulation conditions, to provide data useful for prescribing therapeutic treatments including stimulation therapies, and to monitor the effectiveness of various treatments. The disclosed methods and system can apply to a broad spectrum of diagnosed and/or undiagnosed vascular diseases and extend to detection and treatment of limb or appendage injury. An integrated device which can be a portable or a wearable product which makes use of the new system and method is disclosed.

The present invention discloses an therapeutic ultrasonic device consisting of at least one arc ultrasonic transducer that can be assembled. The arc ultrasonic transducer comprises a protruding part, a concave part and a plurality of piezoelectric vibrating parts. The protruding part and the concave part are disposed at two ends of the arc ultrasonic transducer respectively, and the piezoelectric vibrating parts are disposed at the inner arc face of the arc ultrasonic transducer. Various numbers of arc ultrasonic transducers can be used in assembled structure or non-assembled structure according to different body size and focal zones of various target tissue. Thus the therapeutic ultrasonic device of the present invention is widely used in treatment of various indications.

This invention relates to the treatment of a patient's lung, for example, a lung exhibiting chronic obstructive pulmonary disease (COPD) and in particular to methods and devices for affecting lung volume reduction, preferably for achieving acute or immediate lung volume reduction following treatment. The lung volume reduction is effected by delivering a condensable vapor at a temperature above body temperature to the desired regions of the patient's lung to damage tissue therein. Blood flow and air flow to the damaged tissue region is essentially terminated, rendering the target region non-functional. Alternative energy sources may be used to effect the thermal damage to the lung tissue.

The disclosure describes imaging and therapy techniques comprising nanodroplets. More particularly, aspects of the disclosure relate to the use of nanodroplets to modify nanobubbles or microbubbles to provide improved imaging and/or therapeutic techniques and compositions.

Lung tumors are treated in-vitro and in-vivo by an apparatus and method for operating the apparatus wherein the lung being treated is made receptive to ultrasound in order to allow the ultrasound waves to be guided through the healthy lung tissue to the tumor tissue in an optimized manner for the use of FUS therapy.

The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles.

A device for generating ultra-wideband bursts of ultrasound in body tissue, comprising: a) ultrasound generating elements that together generate the bursts in the body tissue; and b) a signal generating module that generates signals used by each of the ultrasound generating elements to generate bursts having a specified intensity and spectrum at a specified target location; wherein the device is capable of generating a train of bursts at least a distance 1 cm inside a tank of water, having a specified intensity and a specified spectrum as a function of frequency, at least over a range of frequency covering a factor of 3 in frequency, wherein an effective spectrum which is the specified spectrum adjusted for a response of resonators having a Q of 5, has 50% of its power in that range spread out over a highest power portion of the range covering at least 32% of the range.

A method for controlling a histotripsy using a confocal fundamental and harmonic superposition combined with hundred-microsecond ultrasound pulses, including: 1) positioning a target tissue by a monitoring and guiding system and adjusting a position of the target tissue to a focal point of a transducer; 2) first stage: controlling the confocal fundamental and harmonic superposition combined with hundred-microsecond ultrasound pulses to form a shock wave in a focal zone; wherein a negative acoustic pressure exceeds a cavitation threshold; an inertial cavitation occurs to generate boiling bubbles; the boiling bubbles collapse and achieve partial homogenization of the target tissue; 3) second stage: controlling the confocal fundamental and harmonic superposition combined with hundred-microsecond pulsed-ultrasound sequences to simultaneously irradiate a target zone and further mechanically disintegrate and homogenize the target tissue.

This disclosure describes devices, systems, and methods related to therapeutic ultrasound. An exemplary system includes a transducer configured to emit therapy ultrasound waves towards a therapy site and an ultrasound imaging device configured to emit plane wave ultrasound waves towards the therapy site. The system further includes a controller coupled to the transducer and the ultrasound imaging device. The controller is configured to send an activation signal to the transducer and send an activation signal to the ultrasound imaging device. The controller is further configured to receive image data from the ultrasound imaging device and generate bubble cloud image data based on the received image data.

Features for high intensity focused ultrasound (HIFU) are described. The application of HIFU for ablating tissue may be monitored in real time by imaging bubbles generated during HIFU. A single transducer array may be used by fast switching between imaging and HIFU. For imaging, the array or portions thereof may be used in receive only mode to locate bubbles generated by the HIFU. The application of HIFU, such as location and/or intensity, may be adjusted based on information from the imaging of the bubbles. Physicians and/or others may use these systems and methods to monitor HIFU procedures in real-time for optimal ablation of target tissue with minimal damage to healthy tissue.