A biodegradable and biocompatible barrier membrane of piezoelectric nano composites of Metallic Oxide (MO) (e.g., Magnesium oxide, Zinc oxide and iron oxide)-PLLA (Poly-L-lactide), which can be subjected to acoustic pressure from ultrasound, to generate useful electrical charge for enhanced bone regeneration and enhanced antibacterial effects for guided bone regeneration to treat dental diseases, such as periodontitis.

A treatment tool may generate and transmit a predetermined bioactive frequency and/or waveform of electromagnetic energy and/or acoustic energy into a given region of treatment for inducing a particular cellular outcome/behavior of at least one targeted cell selected from the region of treatment. The region of treatment may be at least a single organism or portion thereof. The region of treatment may include other different types of cells in addition to the at least one targeted cell. The treatment tool may be used in vivo, non-invasively, and selectively, wherein the particular cellular outcome/behavior occurs in the at least one targeted cell but not other cells. The treatment tool may have a transmitter assembly, an antenna tuner, an attenuator, a broadband power amplifier, and a frequency/waveform generator; and the treatment tool may also have a computer. The treatment tool may be used to treat cancers and/or other conditions.

Methods and systems are provided for treating target cells in a target tissue. The method comprises: determining frequency and magnitude of a periodic force to be applied to the target cells to trigger a mechanically-induced apoptotic process in the target cells; and generating a sequence of programmed cycles of waves to the target tissue to apply the periodic forces to the target cells for a period of time. In some cases, the frequency, magnitude and the period of time are determined based at least in part on the type of target cells or mechanical properties of the target cells.

A treatment system has a base unit and a portable unit. The base unit has a pliable top layer and one or more ultrasonic transducers configured to produce ultrasound waves into the pliable top layer. The portable unit has a pliable pad and an ultrasonic transducer producing ultrasound waves into the pliable pad. The portable unit also has a source of ionizing electromagnetic radiation configured to emit in ionizing electromagnetic radiation.

An improved system and method of endobronchial imaging of lung nodules comprises the introduction of a perfluorocarbon (PFC) liquid into pulmonary passages of the lungs, the introduction of which enables better coupling between an endobronchial ultrasonic imaging system and a target tissue site within the pulmonary passages of the lungs, the improved coupling between the ultrasonic imaging system and a target tissue site being imparted by the removal (at least in part) the air interface present between the ultrasonic imaging system and the surface of the target tissue site. Furthermore, the unique properties of perfluorocarbon liquids (for example, the properties of superb biocompatibility, high affinity for dissolving oxygen, and extremely low surface tension) further position these substances to be particularly well-suited for this application.

Various approaches for enhancing treatment of target tissue using a source of focused ultrasound while limiting damage to non-target tissue include selecting a frequency of ultrasound waves transmitted from the source of focused ultrasound for generating a focus in the target tissue; providing microbubbles having the first size distribution such that at least 50% of the microbubbles have a radius smaller than a critical radius corresponding to a resonance frequency matching the selected frequency of ultrasound waves; and applying the ultrasound waves at the selected frequency to treat the target tissue.

A method is provided for delivering directed transmission of sound waves through modulation on an ultrasonic carrier. In some embodiments, the method comprises connecting at least one directed sound source to an audio system and emitting, via the at least one directed sound source, audio from the audio system, wherein the emitting comprises emitting medium frequency audio sound waves and higher frequency audio sound waves. The audio may be selected via a master control unit, operatively coupled to a mobile application. In some embodiments, a first audio selection is configured to be heard only through a first directed sound source, and a second audio selection is configured to be heard only through a second directed sound source. Additionally, systems and methods are provided for delivering therapeutic sound, through a sinusoidal signal, within an environment intended to cause resonance in certain cells.

A system for the therapeutic treatment of joints comprising a composite material comprising a biodegradable polymer matrix and a plurality of piezoelectric particles adapted to generate local electric charges in response to an external stimulation made by means of ultrasound, said plurality of piezoelectric particles being dispersed in the matrix. The composite material also comprises a plurality of stamina cells dispersed in the biodegradable polymer matrix and a plurality of carbon-based particles. The system also comprises a releasing device, arranged to deposit the composite material in a joint cavity at predetermined areas of the cartilage, and a stimulator device arranged to emit ultrasound at a predetermined frequency, a predetermined intensity and for a predetermined time of application, in such a way that, when the device is located near a joint wherein the composite material has been deposited, said ultrasound stimulate the plurality of piezoelectric particles.

A method for directing ultrasound energy toward an organ of a subject, including: determining a location of the organ within the subject's body; and directing ultrasound energy at the location of the organ within the subject's body using a wearable ultrasound device.

The disclosure describes imaging and therapy techniques comprising nanodroplets. More particularly, aspects of the disclosure relate to the use of nanodroplets to modify nanobubbles or microbubbles to provide improved imaging and/or therapeutic techniques and compositions.