Methods, systems, and computer readable media for utilizing a therapeutic ultrasound device to perform mitral valve decalcification are disclosed. One method includes acquiring, via an ultrasound imaging component, imaging data of a mitral valve in real-time, defining a therapeutic region of interest corresponding to the mitral valve, and utilizing, by a system controller engine, imaging data from the ultrasound imaging component to determine an interval period of minimal mitral annular movement. The method further includes defining a sequence of therapeutic targets within the region of interest of the mitral valve, utilizing the imaging data acquired in real-time by the ultrasound imaging component to provide a therapeutic ultrasound transducer array with a location and depth of an intra-annular focal zone within the mitral valve, and emitting a high intensity focused ultrasound (HIFU) pulse wave from the therapeutic ultrasound transducer array to each of the therapeutic targets of the mitral valve during the determined interval period and in accordance with the defined sequence.

A system for delivering drugs or other molecules to the brain comprises an ultrasound imaging transducer configured to image structures such as the circle of Willis within a patient's head by way of a low attenuation acoustic window. The system includes a processor configured to register the ultrasound images to previously obtained images which also include the structures. The system includes ultrasound transducer elements operable to deliver ultrasound energy to a target region to cause the blood brain barrier to open. The system may include a drug delivery system that may be operated to deliver a drug to the patient in coordination with opening the blood brain barrier. Coordinates of the target region relative to the ultrasound imaging transducer are determined using registration information.

A catheter for ultrasonic-driven bladder therapeutic agent delivery, including: a tube having a proximal expandable portion and a distal end, and at least one transducer sleeve accommodating at least one ultrasound transducer mounted on the tube between the proximal expandable portion and the distal end.

The present disclosure provides for methods of delivering cargo material to a cell(s) in vivo or in vitro, devices configured to deliver cargo material to the cell, systems configured to deliver cargo material to the cell, and the like. The present disclosure can synergistically combine multiple technologies to improve the rate of cargo material introduction and utility of physical cellular modification in a transformative way compared to the current microinjection state-of-the art.

The tissue removal device using focused ultrasound includes a focused ultrasound output unit, a mode setting unit to set an output mode of the focused ultrasound, and a control unit to control output characteristics of the focused ultrasound according to the set mode, wherein the output mode is selected from a first mode for removing a tissue in a local area using a vapor bubble formed by the focused ultrasound, a second mode for removing a tissue in a narrower area than the first mode by controlling the output characteristics of the focused ultrasound immediately after the vapor bubble is formed by the focused ultrasound, and a third mode for obtaining a skin tightening effect by generating heating in a subcutaneous fat layer using focused ultrasound of lower intensity and a longer pulse length than the first mode and the second mode.

The present invention relates to ultrasound mediated delivery of therapeutic agents to the pancreas, and particularly for treatment of pancreatic cancer such as pancreatic ductal adenocarcinoma (PDAC). More particularly, the invention provides a cluster composition and a pharmaceutical composition, for use in delivery of therapeutic agents and for treatment of pancreatic cancers, including PDAC.

The present disclosure provides an ultrasound therapy system and a dose control method. The system includes: a control device; a first ultrasound irradiation device configured to generate multiple groups of ultrasound irradiation doses driven by the control device and conduct ultrasound irradiation on a cell culture device with multiple groups of abnormally proliferating living cells; a characterization image capture device configured to capture performance characteristic data of living cells in the cell culture device, where the control device is further configured to determine an ultrasound irradiation dose corresponding to at least one group of abnormally proliferating living cells with a cell target characteristic characterization as a target ultrasound irradiation dose according to the performance characteristic data; and a second ultrasound irradiation device configured to conduct ultrasound irradiation of the target ultrasound irradiation dose on a living organism with abnormal proliferation.

The present invention provides novel compositions and methods for targeted delivery of therapeutics. In particular, the invention provides compositions comprising a plurality of carriers, such as microbubbles, wherein at least one active agent is associated or co-administered with the plurality of carriers for delivery to a target site, e.g., an organ, a tissue, or a tumor site, in a subject. The present invention also provides methods for treating a disease or condition, methods of targeted delivery of an active agent, e.g., to a target site, in a subject, using the carriers based compositions of the invention. The present invention further provides apparatus, devices and methods for preparing the compositions of the present invention.

A high-low intensity focused ultrasound treatment apparatus according to the present disclosure includes a plurality of ultrasound sources, and a controller to control a center frequency and intensity of focused ultrasound outputted from the ultrasound sources, wherein each of the ultrasound sources includes a first ultrasound transducer to output low-intensity focused ultrasound to detect a lesion, and a second ultrasound transducer to output high-intensity focused ultrasound to ablate or remove the detected lesion. The low-intensity focused ultrasound outputted from the first transducer may be used to detect a lesion in a patient's brain by applying a stimulus to the brain, and at the same time, investigating a response, and the high-intensity focused ultrasound outputted from the second transducer may be used to ablate or remove the detected lesion by applying a thermal or mechanical stimulus to the lesion.

A catheter for ultrasonic-driven bladder therapeutic agent delivery, including: a tube having a proximal expandable portion and a distal end, and at least one transducer sleeve accommodating at least one ultrasound transducer mounted on the tube between the proximal expandable portion and the distal end.