Estimation of vibration amplitude of intra-capillary micro-bubbles driven to vibrate with an incident ultrasound wave with amplitude and frequency to adjust the drive amplitude of the incident wave to obtain specified vibration amplitude of extra-capillary tissue. Estimation uses transmission of M groups of pulse complexes having low frequency pulse (LF) at bubble drive frequency, and high frequency (HF) pulse with angular frequency ω.sub.H>˜5ω.sub.L, and pulse duration shorter than π/4ω.sub.L along HF beam. The phase between HF and LF pulses is ω.sub.Lt.sub.m for each group, where t.sub.m varies between the groups. Within each group, LF pulse varies between pulse complexes in amplitude and/or, where the LF pulse can be zero for a pulse complex, and LF pulse is different from zero for pulse complex within each group. HF receive signals are processed to obtain a parameter relating to bubble vibration amplitude when the HF pulse hits bubble.

An implantable ultrasound generating treating device (12) to induce spinal cord or spinal nerves treatment, suitable for implantation in the spinal canal and comprises an elongate support member (22, 32) and an array of several treatment transducers (20) distributed along the elongate support member. The several treatment transducers (20) comprise radial transducers emitting an ultrasound treatment beam oriented radially, wherein the treatment transducers (20) have a resonant frequency comprised between 0.5 and 4 MHz. The device has articulating portions so that the implantable device can adapt its shape to a curved elongation path. Also disclosed is an apparatus including the implantable ultrasound generating treating device and methods comprising inserting the implantable ultrasound generating treating device (12) inside the spinal canal of the spine of the patient.

In an embodiment, a method for effecting thermal therapy using an in vivo probe includes positioning the probe in a volume in a patient, identifying an irregularly shaped three-dimensional region of interest and automatically applying thermal therapy to the region using the probe. Applying thermal therapy may include identifying a first emission level at a first rotational angle based in part on a depth of a radial portion of the region in the direction of probe emission, activating emission of the probe, causing rotation of the probe to a next rotational angle, identifying a next emission level at the next rotational angle based in part on a depth of a radial portion of the region in the direction of probe emission, activating emission to deliver therapeutic energy, and repeating rotation and emission until therapeutic energy has been delivered to the volume.

For fixedly implanting a device for material or signal delivery or acquisition or a part of such a device in a human or animal body, an opening is provided in hard tissue of the body, the opening reaching through a hard tissue layer, e.g. through a cortical bone layer into cancellous bone underneath. The device includes a plug portion and/or a cover portion which includes a ring of a material having thermoplastic properties extending around the plug portion or on a tissue facing surface of the cover portion. The opening provided in the hard tissue has a cross section at least in the area of its mouth that is adapted to the plug or cover portion such that the plug portion can be introduced through the mouth of the opening or the cover portion can be positioned over the mouth of the opening such that the ring extends around the opening, along its wall and/or on the hard tissue surface around its mouth.

An apparatus and method stimulate or sense neurons or groups of neurons in a subject, e.g., a human or animal brain, with positional dependence. This utility is provided in part by utilizing individually-addressable Radio-Frequency IDentification (RFID) coils so that locations of those coils in the brain would be monitored and known.

A robotic device for performing intracranial procedures, comprising a baseplate for mounting on the subject's skull and a rotatable base element rotating on the baseplate. The rotatable base element has a central opening through which a cannulated needle can protrude such that it can rotate around an axis perpendicular to the baseplate. This cannulated needle is robotically controlled to provide motion into and out of the subject's skull. A flexible needle is disposed coaxially within the cannulated needle, and it is controlled to move into and out of a non-axial aperture in the distal part of the cannulated needle. Coordinated control of the insertion motion of the cannulated and flexible needles, and rotation of the combined cannulated/flexible needle assembly enables access to be obtained to a volume of a region of the brain having lateral dimensions substantially larger than the width of the cannulated needle.

The present invention relates to an implantable ultrasound (US) generating device for implantation within the vertebral column of a vertebrate subject, wherein the implantable US generating device comprises at least one US generating transducer suitable for emitting US beam(s) with an oblique orientation with respect to a longitudinal axis of a vertebral column.

The present invention discloses an advance in enhanced stability, enhanced solubility, and enhanced uniqueness towards a micro needling stamper device by proposing an improved process by presenting a technique where skin care products are delivered by way of a needling device is presented. The device has a suction that operates in the casing of the needles. When the stamping of the microneedles occurs, this suction feature lift the skin from it's a regular lying surface. The suction feature promotes blood circulation which will promote cell repair and aide in regeneration. This vacuum like suction separates different layers of tissues, thus microtrauma from the needles is more confined to the layer desired; the epidermis. This also triggers an inflammatory response flooding the area with white blood cells, platelets, and other healing aids for the re-generation process.

An apparatus having an implantable ultrasound generating treating device to induce brain disorder treatment, suitable for implantation in or under the skull bone of a patient, includes several ultrasound generating transducers, which are connectable by a common electrical connection circuit to a generator, and wherein the ultrasound generating transducers each have one or several operating frequencies. The transducers include the group of transducers having several transducers driven by a same electrical drive signal, and connected to the generator system by a common electrical connection circuit, where the electric drive signal serves both as power signal and as a control signal for operating selectively, within said group, at least one or the other of a first transducer or sub-group of transducers, and of a second transducer or sub-group of transducers. The apparatus is also used to treat brain disorders.

An implantable ultrasonic transducer device for capturing radiographic and biometric data is provided. The implantable ultrasonic transducer device includes a transducer array configured to provide ultrasonic waves to a target area and to obtain reflected ultrasonic waves from the target area; a controller electrically coupled to the transducer array and configured to provide one or more control signals to the transducer array to control one or more modes of operation of the transducer array; and an antenna electrically coupled to the controller and configured to wireless transmit and receive data from an external device, wherein the transducer array, the controller, and the antenna are completely contained within a body cavity of a patient and an activation surface of the transducer array is positioned in physical contact with a portion of a treatment area of the patient with no air gap between the activation surface and the treatment area.