The present invention relates to an ultrasonic probe for heating, internally, an ultrasonically absorbent target medium, the probe comprising: at least one piezoelectric transducer (21) having a front face (212) intended to be positioned facing the target medium and a back face (211) opposite the front face (212), the transducer being able to emit at least one primary wave emanating from its front face and at least one secondary wave emanating from its back face, the probe being noteworthy in that it furthermore comprises: a reflector (24) facing the back face (211) of the transducer (21), the reflector (24) being suitable for reflecting the secondary wave emitted by the transducer (21); and a cooling-fluid layer (25) between the transducer (21) and the reflector (24).

The invention relates to an interstitial ultrasound ablation device (5) for being inserted into tissue surrounding, for instance, a tumor. The interstitial ultrasound ablation device comprises an arrangement (7) of ultrasound units (17, 18) for a focal ablation treatment which is modifiable from a folded configuration, to be used while inserting the ultrasound ablation device into the tissue, to an unfolded configuration, to be used after the ultrasound ablation device has been inserted into the tissue, such that the unfolded arrangement of ultrasound units is next to the tumor. This ultrasound ablation device can be easily positioned close to the tumor, where the unfolded arrangement of ultrasound units provides a large ultrasound emission area allowing for a very good focusing of the ultrasound on the tumor. This can lead to a very effective ablation of the tumor with only very few or no unwanted side effects.

An implantable ultrasound generating treating device (12) to induce spinal cord or spinal nerves treatment, suitable for implantation in the spinal canal and comprises an elongate support member (22, 32) and an array of several treatment transducers (20) distributed along the elongate support member. The several treatment transducers (20) comprise radial transducers emitting an ultrasound treatment beam oriented radially, wherein the treatment transducers (20) have a resonant frequency comprised between 0.5 and 4 MHz. The device has articulating portions so that the implantable device can adapt its shape to a curved elongation path. Also disclosed is an apparatus including the implantable ultrasound generating treating device and methods comprising inserting the implantable ultrasound generating treating device (12) inside the spinal canal of the spine of the patient.

The present invention relates to an apparatus and an implantable ultrasound generating treating device and to induce brain disorder treatment, suitable for implantation in or under the skull bone of a patient, and comprising several ultrasound generating transducers (20) which are connectable by a common electrical connection circuit to a generator, and wherein the ultrasound generating transducers (20) each have one or several operating frequencies.

characterized in that the transducers comprise at least:
characterized in that the group of transducers consists of several transducers driven by a same electrical drive signal, and connected to the generator system by a common electrical connection circuit, where the electric drive signal serves both as power signal and as a control signal for operating selectively, within said group, at least one or the other of a first transducer or sub-group of transducers, and of a second transducer or sub-group of transducers.

The present disclosure provides an apparatus or system and methods for treating xerostomia or Sjgren's Syndrome in a subject.

A method and system of neural stimulation and imaging of nervous system of a subject. The method includes the steps of providing an interface device operable to generate an ultrasonic beam for neuroniodulation and imaging of a targeted neural structure of a subject, implanting the interface device in the subject, and providing and disposing an external coil array over the targeted neural structure of the subject, wherein the external coil array is wirelessly powering and communicating with the interface device.

Image-guided therapy of a tissue can utilize magnetic resonance imaging (MRI) or another medical imaging device to guide an instrument within the tissue. A workstation can actuate movement of the instrument, and can actuate energy emission and/or cooling of the instrument to effect treatment to the tissue. The workstation and/or an user of the workstation can be located outside a vicinity of an MRI device or other medical imaging device, and drive means for positioning the instrument can be located within the vicinity of the MRI device or the other medical imaging device. The instrument can be an MRI compatible laser or high-intensity focused ultrasound probe that provides thermal therapy to, e.g., a tissue in a brain of a patient.

A method and/or system are provided for improving kidney function and/or increasing Glomerular Filtration Rate (GFR) of the renal system, by applying acoustic and/or ultrasonic energy to one or more of the kidneys. The method suggests either focused or non-focused (or combined) energy delivery, optionally in a noninvasive approach, which could also be implemented invasively and/or by implantable device.

Potential applications of this technique, include, but are not restricted to, treatment of renal disorders such as CKD (Chronic Kidney Disease) and/or AKI (Acute Kidney Injury), short term or long term intervention in kidney function for therapeutic or diagnostic purposes, modifying urine output in heart failure, modulating blood volume and/or pressure, and modulating clearance of compounds in the blood are typically difficult to extract from the kidneys, such as iodine, other imaging contrast media, and similar compounds.

The subject matter discloses a detection unit (102) adapted for performing facial skin diagnose in a treated area and for providing a first measurement of skin layers thickness or for providing a second measurement of defected or infected skin tissue in a treated area; a microneedles array 1032 adapted for performing an injection process for treating said defected or infected skin tissue; in accordance with said first measurement or said second measurement; and a cooling system adapted for cooling down said treated area prior to said injection; said cooling down is for reducing pain.

A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient.