A dual-mode ultrasound system provides real-time imaging and therapy delivery using a transducer array. The system may use various imaging modes to provide image data that may be used to select control points within an imaging field of view. The control points along with the image data may be used to solve an optimization problem to achieve desired focusing gains at one or more of the control points. The optimized solution may be used to produce excitation waveforms to generate new image data. The focusing gains may be evaluated and the optimization problem may be iterated until desired focusing gains are achieved. Virtual arrays may be defined and cascaded to provide flexibility in solving the optimization problem.

Cancer treatment methods using thermotherapy and/or enhanced immunotherapy are disclosed herein. In one embodiment, the method comprising the steps of administering a plurality of nanoparticles to target a tumor in a patient, the nanoparticles being coated with an antitumor antibody, cell penetrating peptides (CPPs), and a polymer, and the nanoparticles containing medication and/or gene, and a dye or indicator in the polymer coating, at least some of the nanoparticles attaching to surface antigens of tumor cells so as to form a tumor cell/nanoparticle complex; exciting the nanoparticles using an ultrasound source generating an ultrasonic wave so as to peel off the polymer coating of the nanoparticles, thereby releasing the dye or indicator into the circulation of the patient and the medication and/or gene at the tumor site; and imaging a body region of the patient so as to detect the dye or indicator released into the circulation of the patient.

A method of delivery of an ultrasound-guided drug-loaded microbubble, an electronic device, and a computer-readable storage medium are provided. The method includes: emitting a first ultrasonic signal by utilizing an array transducer, to break a drug-loaded microbubble in a current breaking region; emitting a second ultrasonic signal by utilizing the array transducer, to obtain an ultrasound image; identifying a contour of a blood vessel of the breaking region based on the ultrasound image; and updating a characteristic parameter of the breaking region based on the contour of the blood vessel. According to the method, the breaking region is updated in real time based on the contour of the blood vessel, so that delivery accuracy of a drug-loaded microbubble is improved, and avoiding unnecessary tissue damage.

Features for high intensity focused ultrasound (HIFU) are described. The application of HIFU for ablating tissue may be monitored in real time by imaging bubbles generated during HIFU. A single transducer array may be used by fast switching between imaging and HIFU. For imaging, the array or portions thereof may be used in receive only mode to locate bubbles generated by the HIFU. The application of HIFU, such as location and/or intensity, may be adjusted based on information from the imaging of the bubbles. Physicians and/or others may use these systems and methods to monitor HIFU procedures in real-time for optimal ablation of target tissue with minimal damage to healthy tissue.

The system and process of therapeutic and effective cavitation by using ultrasound to collapse gas vesicles as well as cavitate the bubbles produced from the collapsed gas vesicles. Therapeutic effect includes, but is not limited to lysing cells by cavitation. The cells expressing the gas vesicles can optionally be used as delivery cells to preform tasks such as transporting the gas vesicles into deep tissue areas, releasing compounds at the cavitation site, and more. The gas vesicles can optionally be modified to facilitate getting the bubbles near the cavitation targets by functionalizing the gas vesicles.

Methods for treating skin and subcutaneous tissue with energy such as ultrasound energy are disclosed. In various embodiments, ultrasound energy is applied at a region of interest to affect tissue by cutting, ablating, micro-ablating, coagulating, or otherwise affecting the subcutaneous tissue to conduct numerous procedures that are traditionally done invasively in a non-invasive manner. Methods of lifting sagging tissue are described.

A method of modulating glandular secretions by administering acoustic shock waves to a reflexology zone has been discovered. In one preferred embodiment, a treatment method achieves one or more of a) modulating blood sugar levels, b) stimulating insulin production levels or c) normalizing A1C levels by administering acoustic shock waves to a reflexology zone or region of a patient. The treatment method further has the steps of: activating acoustic shock waves of an acoustic shock wave generator to emit acoustic shock waves; subjecting the reflexology zone to acoustic shock waves stimulating the pancreas to have a modulated response wherein the modulated response is one of an adjustment in blood sugar levels or insulin production and release or normalizing A1C levels which increases low level output, decreases high level output or stabilizes erratic output; and wherein the emitted acoustic shock waves are focused or unfocused.

A system to detect occlusion of an intravenous catheter may include a housing, which may include a distal end configured to couple to a proximal end of a catheter adapter and an inner lumen forming a fluid pathway. The system may also include one or more transmitters, which may be disposed within the housing. The transmitters may be configured to transmit first energy waves along a length of an intravenous catheter at a first frequency, and a portion of the first energy waves that are reflected back from the catheter may be detected by the system. Based on the portion of the first energy waves that are reflected back from the catheter, the transmitters may transmit second energy waves along the length of the catheter at a second frequency, which may be greater than the first frequency and configured to reduce formation of blood clots within the catheter.

Composite medical treatment apparatus using skin map disclosed. The composite medical treatment apparatus includes a handpiece configured for measuring a skin condition associated with a measurement position on a region of interest in a skin map generation step, and configured for measuring a treatment position on the region of interest and applying a treatment medium according to a control parameter corresponding to the treatment position in a treatment step and a main controller configured for associating the measurement position with the skin condition in the skin map generation step, and configured for retrieving the skin condition associated with the measurement position based on the treatment position to generate the control parameter in the treatment step.

A biological object image-capturing and treatment system includes a micro detection and treatment device, and an AI model. The micro detection and treatment device includes a plurality of signal transmitting and receiving elements, wherein one of the signal transmitting and receiving elements continuously transmits a stimulation signal with different parameter values to a particular target, and one of the signal transmitting and receiving elements continuously receives response signal from the particular target. The AI model uses the response signals to perform machine learning, and outputs a parameter value adjustment suggestion to the micro detection and treatment device according to result of the machine learning. The micro detection and treatment device adjusts the parameter value of the stimulation signal according to the parameter value adjustment suggestion.