A flexible variable frequency ultrasonic therapeutic probe based on thermoacoustic effect of a carbon nanotube film comprises an ultrasonic sound production element, and a heat dissipation layer and an acoustic matching layer located on both sides thereof. The sound production element comprises a carbon nanotube film, metal electrodes and wires, and the shape and size of the sound production element can be adjusted according to the actual functional requirements. When a signal is accessed into the sound production element, the carbon nanotube film produces a corresponding temperature change, which causes the surrounding media to expand and contract and to excite ultrasonic waves. The present invention greatly improves the coupling efficiency between the probe and the subject, reduces the energy loss of ultrasonic waves, and enhances the uniformity of the sound intensity distribution in the affected part.

An anti-tumor agent is provided to a patient to increase a susceptibility of a tumor within the patient to harmonic excitation. Ultrasonic transducers of a wearable are driven to direct a therapeutic ultrasound signal into tissue of the patient. The therapeutic ultrasound signal has a resonant ultrasound frequency to harmonically excite and damage the tumor while the anti-tumor agent has increased the susceptibility of the tumor to the harmonic excitation of the therapeutic ultrasound signal.

Methods and systems for treating skin, such as stretch marks through deep tissue tightening with ultrasound are provided. An exemplary method and system comprise a therapeutic ultrasound system configured for providing ultrasound treatment to a shallow tissue region, such as a region comprising an epidermis, a dermis or a deep dermis. In accordance with various exemplary embodiments, a therapeutic ultrasound system can be configured to achieve depth with a conformal selective deposition of ultrasound energy without damaging an intervening tissue. In addition, a therapeutic ultrasound can also be configured in combination with ultrasound imaging or imaging/monitoring capabilities, either separately configured with imaging, therapy and monitoring systems or any level of integration thereof.

One embodiment is directed to a non-contact, medical ultrasound therapy system for generating and controlling low frequency ultrasound. The ultrasound therapy system includes a treatment wand including an ultrasonic transducer, a generator unit, and a cable coupling the treatment wand to the generator unit. The generator unit generates electric power output to drive the ultrasonic transducer and includes a digital frequency generator, wherein the generator unit digitally controls energy output at resonance frequency of the ultrasonic transducer.

The invention provides methods for treating a neurological disorder or deficit, such as tinnitus and phantom limb pain.

Methods and systems for treating skin, such as stretch marks through deep tissue tightening with ultrasound are provided. An exemplary method and system comprise a therapeutic ultrasound system configured for providing ultrasound treatment to a shallow tissue region, such as a region comprising an epidermis, a dermis or a deep dermis. In accordance with various exemplary embodiments, a therapeutic ultrasound system can be configured to achieve depth with a conformal selective deposition of ultrasound energy without damaging an intervening tissue. In addition, a therapeutic ultrasound can also be configured in combination with ultrasound imaging or imaging/monitoring capabilities, either separately configured with imaging, therapy and monitoring systems or any level of integration thereof.

An ultrasound system for an ultrasound therapy (ablation or hyperthermia) of a region of interest comprising: a patch comprising a two-dimensional array of ultrasonic transducers (preferably CMUTs) arranged on a support, wherein a plurality of the transducers is adapted to operate in a variable frequency range; a transducer controller means adopted to activate at least two groups of the plurality of the transducers in the array for a transmission of the ultrasound signals, wherein each of the at least two groups: is arranged in a pattern; and operates at a frequency different from other group's frequency.

A system and method for controlling acoustic energy deposition in various media or objects are disclosed. The system and method can generate an acousto-mechanical or acousto-elastic effect in the various media or objects. The acousto-mechanical or acousto-elastic effect can induce a fragmentation of the media or objects.

A method is provided for achieving transfection of host cells using sonoporation. An acoustic radiation generator is positioned in acoustic coupling relationship with respect to a reservoir containing host cells to be transfected, exogenous material to be incorporated into the host cells, and a cell-compatible fluid medium. The acoustic radiation generator is activated to generate acoustic radiation and direct the acoustic radiation into the reservoir in a manner effective to enable transfection of the host cells with the exogenous material.

Disclosed are methods of producing randomized ultrasound waves for providing sonodynamic therapy. The method includes coupling a sonodynamic therapy device with an array of piezoelectric transducer elements to a skin surface. A controller is configured to generate an electrical drive signal to produce ultrasound waves to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.