A probe (10) transmits and receives diagnostic ultrasound and therapeutic ultrasound. A transmission unit (12) forms a transmission beam of the therapeutic ultrasound having a higher wave number than the diagnostic ultrasound and scans the transmission beam of the therapeutic ultrasound in a therapeutic region set inside a diagnostic region by controlling the probe (10). Since the therapeutic ultrasound having a higher wave number than the diagnostic ultrasound is used, the therapeutic effect is higher than when using a therapeutic ultrasound having a similar wave number to the diagnostic ultrasound, and since the transmission beam of the therapeutic ultrasound is scanned in the therapeutic region, the therapeutic effect is higher than when the transmission beam of the therapeutic ultrasound is not scanned.

In one aspect, in accordance with one embodiment, a method includes acquiring magnetic resonance (MR) data corresponding to bone tissue in an area of interest of a subject that is heated from the application of localized energy. The acquiring includes applying a three-dimensional (3D) ultra-short echo time (UTE) spiral acquisition sequence. The method also includes detecting, from the acquired magnetic resonance data, a change in MR response signal due to a change in at least one of relaxation rate and magnetization density caused by heating of the bone tissue; and determining, based at least in part on the change in the MR response signal, that the temperature of the bone tissue has changed.

In accordance with the present disclosure, ultrasound-based techniques using a combined scanning and treatment array module are employed to find and treat anomalies corresponding to bleed events. By way of example, ultrasound data may be acquired with a scanning array at one or more locations on a patient anatomy. A treatment array may deliver heat to a targeted anomaly to provide therapy. Such a technique may be useful outside of a hospital environment.

The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into an internal tissue to cause tissue displacement and identifying that the tissue displacement has occurred. In one embodiment, the presence of tissue displacement is associated with a desired therapeutic or physiological outcome, such as a change in a molecule of interest.

Various approaches for focusing an ultrasound transducer having multiple transducer elements include causing the transducer elements to transmit ultrasound waves to a target region and measure reflections of the ultrasound waves off the target region; for each of at least some of the transducer elements, adjusting a parameter value associated with said each transducer element based at least in part on parameter values associated with multiple measuring transducer elements weighted by signal quality metrics associated with the reflections measured by the measuring transducer elements so as to improve an ultrasound focus at the target region.

A catheter US transducer container and method of manufacture thereof including a housing, one or more cooling channels oriented longitudinally along a longitudinal axis of the container, a sealing cooling channel cover, one or more PE elements positioned on a floor of the cooling channel, the cooling channel having a trapezoid cross section at any point along the PE element.

Apparatus and methods are described including a catheter ultrasound transducer that includes one or more piezoelectric elements configured to ablate tissue of an ostium of a blood vessel by applying ultrasound energy to tissue of the ostium. An expandable positioner is configured to envelope at least a portion of the catheter ultrasound transducer and to position the catheter ultrasound transducer in the ostium of the blood vessel by contacting a wall of the blood vessel. A system processor in communication with the one or more piezoelectric elements is configured to regulate a parameter of the ultrasound energy emitted from the one or more piezoelectric elements based on impedance measurement between one or more electrodes located on the expandable positioner and one or more electrodes located on the catheter ultrasound transducer. Other applications are also described.

Apparatus and methods are described including positioning an ultrasound transducer at a blood vessel ostium, rotating the transducer about its axis and scanning tissue of the blood vessel ostium, recording one or more baseline returned signals from the tissue, and creating a baseline image of the blood vessel ostium based on at least one of the returned signals. Tissue of the blood vessel ostium is ablated in consecutive segments by rotating the transducer segmentally until full rotation is completed. The returned signals of the ablated segments are recorded in real-time and a real-time image is created based on the one or more returned signals. Ablation is terminated after changes in the real-time returned signals and/or real-time image with respect to the baseline returned signals and/or baseline image indicate an achieved predetermined level of ablation lesion formation. Other applications are also described.

The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue at multiple regions of interest, concurrently or consecutively. The neuromodulation may result in tissue displacement, which may be observed through changes in one or more molecules of interest.

Embodiments of tissue monitoring and therapy systems and methods are disclosed. In some embodiments, a monitoring and therapy system comprises collecting video images of a tissue site, amplifying said video images via Eulerian Video Magnification, and determining a treatment parameter from the amplified video images detectable by Eulerian Video Magnification. If the treatment parameter differs from a threshold, an alert may be generated.