A system and method, including an ultrasound imaging transducer, an ultrasound therapy transducer, a robotic arm configured to orient the ultrasound imaging transducer and the ultrasound therapy transducer about a patient, a display connected to imaging transducer, and a memory, storing instructions that when executed by a processor receive ultrasound images from the imaging transducer, present ultrasound images, receive an input to alter a shape of a contour line, present the contour line, receive an input of a size of a margin around the treatment area, present the margin, determine end points at locations where X, Y, and Z axes bisect the contour line in an XZ plane and a YZ plane, drive the ultrasound therapy transducer to a location where a focal point of the ultrasound therapy transducer is at the end point, and determining whether a resistance to movement exceeds a threshold.

A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient.

Ultrasound transducer element arrays using acoustic ensonification drive patterns via a patient interface for sonosensitizer activation in sonodynamic therapy. Acoustic field generation varying phase, frequencies, and/or amplitude via controlled delivery of low intensity planar acoustic waves. Method includes generating a first and a second signal to generate respective acoustic ensonification drive patterns with phase, frequency, and amplitude and generating at least one relative phase, frequency or amplitude difference to generate a third incoherent acoustic ensonification pattern to activate a sonosensitizer.

Systems and methods use the anatomy of the target brain region to suggest waveforms for optimal stretching of the target tissue for neuromodulation. Cell orientation, white matter tracts, or direction of connection between brain regions of the target region are considered. The timing of waveforms generated is based on time constants relevant to the target brain region and structures. The System can lock into the phase and frequency of the target using physiological measurements provided by EEG or other physiological signals. The system provides recommendations on the number of transducers to use, the placement of the transducers, and other ultrasound stimulation parameters. In an embodiment, the system generates waveforms where the spatial derivates of pressure are maximized to improve the efficacy of the stimulation.

The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue at multiple regions of interest, concurrently or consecutively. The neuromodulation may result in tissue displacement, which may be observed through changes in one or more molecules of interest.

A stereotactic device wearable by a patient for low-intensity focused-ultrasound neuromodulation has a support frame shaped to be fitted around a head of the patient, a first movable component having an arched shape and having a first end and a second end engaged with the support frame at respective first and second coupling points. A second movable component has an engagement portion with the first movable component adapted to allow the second movable component to move integrally with the first movable component and to slide along the first movable component to take a plurality of positions between a first position in which the second movable component is proximal to the first end and a second position in which the second movable component is proximal to the second end. A low-intensity focused-ultrasound neuromodulation module housed in a support portion of the second movable component has a low-intensity focused-ultrasound sonication probe.

Apparatus, systems, and methods for treating an eye utilizing ab externo pressure wave generation. The shockwave generator comprises a housing comprising a fluid-filled chamber and an eye-contacting surface or chamber configured to contact a surface of the eye. First and second coaxially-aligned electrodes disposed within the housing are configured to generate an electric arc across a gap between the electrode tips when energized and thus produce a shockwave in a fluid of the fluid-filled chamber. The shockwave generator is coupled to the surface of the eye before focusing a shockwave to a pre-determined location on or below the surface of the eye. A plurality of shockwave generators may be disposed within a fluid-filled chamber of a contact lens, which may comprise a contact balloon.

Ultrasound transducer element arrays using acoustic ensonification drive patterns via a patient interface for sonosensitizer activation in sonodynamic therapy. Incoherent acoustic field generation varying phase, frequencies, and/or amplitude via controlled delivery of low intensity planar acoustic waves. Method includes generating a first and a second signal to generate respective acoustic ensonification drive patterns with phase, frequency, and amplitude and generating at least one relative phase, frequency or amplitude difference to generate a third incoherent acoustic ensonification pattern to activate a sonosensitizer. Calibration and complementary therapy procedures to improve cell susceptibility of cells to sonodynamic therapy are disclosed.

A surgical instrument for irradiating a focused ultrasound includes a main body, a driving unit which is provided in the main body to generate arbitrary rotational force, a support plate which is fixed into the main body by forming a spiral guide groove on any one surface and allows one side of the driving unit to penetrate to be supported, a traction unit which is coupled to one penetrating side of the driving unit to rotate in response to the rotational force generated in the driving unit and is movably coupled to the guide groove of the support plate to be pulled to draw a spiral path along the guide groove during the rotation, and a following unit which is coupled to one side of the traction unit to output a focused ultrasound while following the traction motion of the traction unit.