The present invention relates to a therapeutic ultrasonic wave generating device. The present invention includes: a rotating motor; an ultrasonic wave generating unit being provided with a transducer generating ultrasonic waves; and a focus rotation movement unit moving the focus of the ultrasonic waves generated by the ultrasonic wave generating unit in a circle on the same plane by receiving a transmission of rotational force of the rotating motor. The present invention enables: the focus of ultrasonic waves to be moved in the circle having a constant radius at a uniform depth under the skin; and energy to be applied uniformly and evenly within the movement radius, thereby enabling enhancement of therapeutic performance.

The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue at multiple regions of interest, concurrently or consecutively. The neuromodulation may result in tissue displacement, which may be observed through changes in one or more molecules of interest.

An ultrasound transducer array is incorporated in a light-weight, conformable, and wearable patch that may be used to deliver, monitor, and control localized transcranial focused ultrasound (tFUS). The patch may include full-duplex transmit-receive circuitry that may be used for continuous monitoring of transcranial focused ultrasound (tFUS) application. The circuitry may include a circulator. The ultrasound transducer array may be coupled to an aperture interface having irregularly sized or shaped channel conductors to provide a coarse aperture for the array. The coarse aperture may be designed using a method that provides a reduced channel count.

Various approaches to focusing an ultrasound transducer includes causing the ultrasound transducer to transmit ultrasound waves to the target region; causing the detection system to indirectly measure the focusing properties; and based at least in part on the indirectly measured focusing properties, adjusting a parameter value associated with at least one of the transducer elements so as to achieve a target treatment power at the target region.

Apparatus, systems, and methods for treating an eye utilizing ab externo pressure wave generation. The shockwave generator comprises a housing comprising a fluid-filled chamber and an eye-contacting surface or chamber configured to contact a surface of the eye. First and second coaxially-aligned electrodes disposed within the housing are configured to generate an electric arc across a gap between the electrode tips when energized and thus produce a shockwave in a fluid of the fluid-filled chamber. The shockwave generator is coupled to the surface of the eye before focusing a shockwave to a pre-determined location on or below the surface of the eye. A plurality of shockwave generators may be disposed within a fluid-filled chamber of a contact lens, which may comprise a contact balloon.

A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient.

A focused-ultrasound or other procedure for treating a target within a tissue region can be planned iteratively by creating a treatment plan specifying a treatment location pattern and stimuli applied thereto, simulating the treatment, computationally predicting an effect of the simulated treatment, comparing the predicted effect against one or more treatment constraints (such as efficacy and/or safety thresholds), and, if a constraint is violated, repeating the simulation for an adjusted treatment plan.

In a wave focusing device and a wave emitting device having the wave focusing device, the wave focusing device has a plurality of filters and focuses a wave by a phase overlap. The plurality of filters includes a first filter formed on a substrate, a second filter formed on the substrate and overlapping with the first filter in a first area, and a third filter formed on the substrate and overlapping with the second filter in a second area. A size of the first area is substantially same as that of the second area. A first portion of the second filter in the first area is inverted to a second portion of the second filter in the second area, with respect to a first axis. A wave passing through the wave focusing device is focused at a center of each of the first, second and third filters.

A therapy apparatus for treating tissue by the emission of focused ultrasound waves, including:

a creation surface of a pressure field of focused ultrasound waves divided into at least N sectors having segments of asymmetrical concave curve (S1, S2, . . . ) with centres of curvature;

centres of curvature (c.sub.1, c.sub.2, . . . ) asymmetrical to the extent where the centres of curvature are situated at different distances from the plane of symmetry (A1) or from the axis of symmetry (S) and/or at different depths taken according to the axis of symmetry;

the individual axes (a.sub.1, a.sub.2, . . . ) intersecting between the focal zones (Zc.sub.1, Zc.sub.2, . . . ) and the creation surface (8) or beyond the focal zones such that the beams originating from the sectors intersect to create a focal coverage zone (Zr) which is off-axis relative to the plane of symmetry (A1) or to the axis of symmetry (S);

the sectors of this creation surface (8) creating energy deposit zones with profiles corresponding to the focal coverage zones (Zr).

A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient.