Methods for treating urinary stress incontinence by non-invasively delivering energy to one or more submucosal regions of vaginal tissue to induce remodeling within the vaginal tissue are provided. In some embodiments, the energy delivery results in heating of the target tissue to a temperature that ranges from about 38° C. to about 46° C. In some embodiments, the subject methods involve cooling a mucosal epithelial layer over the vaginal tissue. In some embodiments, a reverse thermal gradient is produced as the mucosal epithelium is cooled while energy is delivered to the underlying vaginal tissue.

An integrated system for increasing skin rejuvenation of a region of a patient's skin and treating subcutaneous fat associated with the region is provided. The system includes at least one first applicator having one or more RF electrodes adapted to be placed on the region of the patient's skin without penetrating the skin. At least one of said RF electrodes is configured to apply RF energy to the region of the patient's skin to heat up to a temperature in a specified temperature range. The system also includes at least one second applicator, in communication with an optical system. The optical system includes at least one laser source and is adapted to provide homogeneous illumination to the skin surface to effect at least one target tissue at a given depth range and power density range.

An integrated system for increasing skin rejuvenation of a region of a patient's skin and treating subcutaneous fat associated with the region is provided. The system includes at least one first applicator having one or more RF electrodes adapted to be placed on the region of the patient's skin without penetrating the skin. At least one of said RF electrodes is configured to apply RF energy to the region of the patient's skin to heat up to a temperature in a specified temperature range. The system also includes at least one second applicator, in communication with an optical system. The optical system includes at least one laser source and is adapted to provide homogeneous illumination to the skin surface to effect at least one target tissue at a given depth range and power density range.

A surgical apparatus comprises a body, a shaft assembly, and an end effector. The end effector comprises a clamp arm and an ultrasonic blade in acoustic communication with an ultrasonic transducer via an acoustic waveguide that extends through the shaft assembly. The clamp arm is configured to pivot about a first pivot point toward and away from the ultrasonic blade along a first angular path from a first position to a second position to thereby provide a tissue sealing mode of operation. The clamp arm is further configured to pivot about a second pivot point toward and away from the ultrasonic blade along second angular path from the second position to a third position to thereby provide a tissue cutting and sealing mode of operation. The second pivot point is proximal to the first pivot point.

A surgical apparatus comprises a body, a shaft assembly, and an end effector. The end effector comprises a clamp arm and an ultrasonic blade in acoustic communication with an ultrasonic transducer via an acoustic waveguide that extends through the shaft assembly. The clamp arm is configured to pivot about a first pivot point toward and away from the ultrasonic blade along a first angular path from a first position to a second position to thereby provide a tissue sealing mode of operation. The clamp arm is further configured to pivot about a second pivot point toward and away from the ultrasonic blade along second angular path from the second position to a third position to thereby provide a tissue cutting and sealing mode of operation. The second pivot point is proximal to the first pivot point.

Intraluminal ultrasound devices, systems and methods are provided. In one embodiment, an intraluminal ultrasound device includes a flexible elongate member configured to be positioned within a body lumen of a patient, the flexible elongate member including a distal portion and a longitudinal axis; and a transducer array disposed at the distal portion of the flexible elongate member and circumferentially positioned around the longitudinal axis of the flexible elongate member. The transducer array includes a plurality of micromachined ultrasound transducers (MUTs). In addition, the transducer array is configured to obtain ultrasound imaging data of the body lumen in response to a first electrical signal, and apply an ultrasound therapy within the body lumen in response to a second electrical signal.

Intraluminal ultrasound devices, systems and methods are provided. In one embodiment, an intraluminal ultrasound device includes a flexible elongate member configured to be positioned within a body lumen of a patient, the flexible elongate member including a distal portion and a longitudinal axis; and a transducer array disposed at the distal portion of the flexible elongate member and circumferentially positioned around the longitudinal axis of the flexible elongate member. The transducer array includes a plurality of micromachined ultrasound transducers (MUTs). In addition, the transducer array is configured to obtain ultrasound imaging data of the body lumen in response to a first electrical signal, and apply an ultrasound therapy within the body lumen in response to a second electrical signal.

A method of distributing data to a transducer array of an ultrasonic device, the transducer array including transduction elements arranged in module units, includes generating a data packet using an optical transceiver controlled by a controller, the data packet including activation instructions encoded in a first wavelength, transmitting the data packet from the controller to a target device via a signal in an optical fiber, the target device having a beam divider device, splitting the data signal, using the beam divider device, into a plurality of data streams, where each of the data streams carries the data packet in an identical phase, transmitting the data streams to the module units, and activating the transduction elements based on the received data streams.

The position and orientation of an ultrasound probe is tracked in three dimensions to provide highly-accurate three-dimensional bone surface images that can be used for anatomical assessment and/or procedure guidance. The position and orientation of a therapy applicator can be tracked in three dimensions to provide feedback to align the projected path of the therapy applicator with a desired path for the therapy applicator or to provide feedback to align the potential therapy field of a therapy applicator with a target anatomical site. The three-dimensional bone surface images can be fit to a three-dimensional model of the anatomical site to provide or display additional information to the user to improve the accuracy of the anatomical assessment and/or procedure guidance.

Methods for treating and managing pain in a patient with therapeutic neuromodulation and associated systems and methods are disclosed herein. Chronic or debilitating pain can be associated, for example, with a disease or condition of the abdominal or reproductive viscera. One aspect of the present technology is directed to methods that at least partially inhibit sympathetic neural activity in nerves proximate a target blood vessel of a diseased or damaged organ of a patient experiencing pain. Targeted sympathetic nerve activity can be modulated at least along afferent pathways which can improve a measurable parameter associated with the pain of the patient The modulation can be achieved, for example, using an intravascularly positioned catheter carrying a therapeutic assembly, e.g., a therapeutic assembly configured to use electrically-induced, thermally-induced, and/or chemically-induced approaches to modulate the target sympathetic nerve.