The present invention relates to phenyl amino pyrimidine compounds which are inhibitors of protein kinases including JAK kinases. In particular the compounds are selective for JAK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.

The present invention describes novel nanoparticle compositions, and systems and methods utilizing them for treating disorders and/or conditions. Methods generally involve administering nanoparticle compositions (e.g., nanoparticle compositions comprising at least one known therapeutic agent and/or independently active biologically active agent; and/or empty nanoparticle compositions) to a subject in need thereof.

There is provided a skin-care balm comprising 15% to 45% (w/w) of two or more waxes, wherein a first wax has a melting point of 70° C. to 90° C. and a second wax has a melting point of 30° C. to 60° C., the balm further comprising 45% to 70% (w/w) of an emollient and a skin soothing agent. The skin-care balm can be applied to the skin in the perinasal area. There is also provided a combination product comprising a skin-care balm and a nasal spray product.

There is provided a skin-care balm comprising 15% to 45% (w/w) of two or more waxes, wherein a first wax has a melting point of 70° C. to 90° C. and a second wax has a melting point of 30° C. to 60° C., the balm further comprising 45% to 70% (w/w) of an emollient and a skin soothing agent. The skin-care balm can be applied to the skin in the perinasal area. There is also provided a combination product comprising a skin-care balm and a nasal spray product.

A combination product comprising a dispensing head (10, 10′) mounted on a top of a container (20, 20′) containing a formulation for nasal administration, and a solidified skin-care balm (50) for application around the nose contained in a balm holder element (30, 30″) located on a bottom (24) of the container (20).

A combination product comprising a dispensing head (10, 10′) mounted on a top of a container (20, 20′) containing a formulation for nasal administration, and a solidified skin-care balm (50) for application around the nose contained in a balm holder element (30, 30″) located on a bottom (24) of the container (20).

The present application relates to a method for obtaining and purifying saponins from plant extracts, through a series of salting and filtrations steps, to provide high purity saponin extracts on large scale.

Chemical entities that modulate PI3 kinase activity, and chemical entities, pharmaceutical compositions, and methods of treatments of diseases and conditions associated with P13 kinase activity are described herein.

An object of the present invention is to provide a compound that has a specific chemical structure having an activation effect on SIRT6 and is useful as an active component for preventing and treating inflammatory diseases, and the present invention relates to a compound represented by Formula (1) or a pharmaceutically acceptable salt thereof,

##STR00001## where each symbol in Formula (1) has the same definition as that described in the specification.

A nasal composition is provided comprising or consisting of a first composition part in the form of a liquid for nasal application to a patient in use, and a second composition part in the form of a powder for nasal application to the patient in use. The first and second composition parts are applied to the patient separately or together as required.