The present invention pertains to a medicament for preventing or treating cough, including, as an active ingredient, a compound having P2X4 receptor antagonistic action, a tautomer, stereoisomer, or pharmaceutically acceptable salt of the compound, or a hydrate or solvate thereof.

The present disclosure relates to benzimidazole derivatives, a preparation method therefor and a medical use thereof. Specifically, the present disclosure relates to a benzimidazole derivative represented by the general formula (I), a preparation method therefor, a pharmaceutical composition containing the derivative, and its use as a therapeutic agent, in particular its use for the treatment of diseases related to P2X3 activity.

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The subject invention refers to the process of extracting phytochemicals and mixing of their active material composition from leaves, roots and fruits of several plants to formulate a cough syrup for the relief and treatment of mild & severe respiratory disorders brought about by bacteria and viruses, dust and pollens that may lead to difficulty in breathing resulting among others to coughs, allergies, colds, nasal congestions, pharyngitis, laryngitis, asthma and sneezing. The efficacy of the mixture of tropical plants having polyphenolic flavonoidal compounds derived from the basic below formula has yielded an effective remedy with little known side effects. I claim the formulations referred to as follows, but not limited thereto: Psidium guajava 25%, Zingiber officinale 30%, Curcuma longa 20%, Euphorbia hirta 10%, Adhatoda vasica 5%, and Citrofortunella microcarpa 3%.

The present invention belongs to the field of medicinal chemistry. Disclosed are a pyridine oxynitride, a preparation method therefor and the use thereof. Specifically, the present invention relates to a series of sodium ion channel blockers with a new structure, a preparation method therefor and the use thereof. The structure thereof is as shown in general formula (I) below. The compounds or a stereoisomer, a racemate, a geometric isomer, a tautomer, a prodrug, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof and a pharmaceutical composition can be used for treating or/and preventing related diseases mediated by a sodium ion channel (NaV).

##STR00001##

Disclosed is a compound of formula (I) and a stereoisomer thereof: ##STR00001##
wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined in the present disclosure.

The present disclosure provides pyrimidine compounds of Formula 1 and uses thereof, for example, for the potential treatment of diseases associated with P2X purinergic receptors: ##STR00001##
In certain aspects, the present disclosure provides P2X3 and/or P2X2/3 antagonists which are useful, for example, for the potential treatment of visceral organ, cardiovascular and pain-related diseases, conditions and disorders.

The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.

The present invention relates to pyrrolidine sulfonamide analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.

Provided are novel salts and polymorphs of 5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-benzenesulfonamide, which are potentially useful for modulating a condition mediated by a P2X3 or P2X2/3 receptor. Also provided are pharmaceutical formulations and methods of administration and dosing of these salts and polymorphs to subjects in need thereof.

The invention provides compounds, compositions, methods, and kits for the treatment or neurogenic inflammation.