A moisturizing lotion composition includes water and propylene glycol having a concentration of 21.0 to 37.5 wt % of the moisturizing lotion composition. In addition, the moisturizing lotion composition includes aloe vera having a concentration of 0.50 to 4.0 wt % of the moisturizing lotion composition, and vervain extract having a concentration of 0.50 to 4.0 wt % of the moisturizing lotion composition. In addition, the moisturizing lotion composition includes willow bark extract having a concentration of 0.50 to 0.20 wt % of the moisturizing lotion composition. Further, the moisturizing lotion composition includes chamomilla recutita extract having a concentration of 0.05 to 0.40 wt % of the moisturizing lotion composition, wherein a ratio of the concentration of the propylene glycol to the concentration of the chamomilla recutita extract is between 4.5 and 5.5.

The application describes creatine or its derivatives, compositions comprising the same, and uses thereof for topical or systemic administration to treat pain, itch, or eczema, or inflammation associated with a cosmetic or medical condition, disorder or disease in a human subject, wherein the inflammation causes the pain, itch, or eczema. In addition, the application describes clinical use of these compounds and compositions which can reduce or eliminate erythema, edema and tissue distortions associated with inflammation.

The application describes creatine or its derivatives, compositions comprising the same, and uses thereof for topical or systemic administration to treat pain, itch, or eczema, or inflammation associated with a cosmetic or medical condition, disorder or disease in a human subject, wherein the inflammation causes the pain, itch, or eczema. In addition, the application describes clinical use of these compounds and compositions which can reduce or eliminate erythema, edema and tissue distortions associated with inflammation.

The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl and pyrrolo[2,3-d]pyridinyl acrylamides and analogues thereof. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.

The present invention relates to a composition for topical application comprising a polyaphron dispersion, the polyaphron dispersion comprising a continuous aqueous phase and at least one discontinuous oil phase, wherein the polyaphron dispersion comprises calcipotriol, betamethasone dipropionate, alpha-tocopherol and butylated hydroxyanisole, and wherein the composition has a pH of 7.75±0.5.

Provided are various embodiments relating to anti-IL31 antibodies binding to canine IL31. Such antibodies can be used in methods to treat IL31-induced conditions in companion animals, such as canines, felines, and equines.

Provided herein are methods of treating or ameliorating hypercholemia or a cholestatic liver disease by administering to an individual in need thereof a therapeutically effective amount of an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI) or a pharmaceutically acceptable salt thereof. Also provided are methods for treating or ameliorating a liver disease, decreasing the levels of serum bile acids or hepatic bile acids, treating or ameliorating pruritis, reducing liver enzymes, or reducing bilirubin comprising administering to an individual in need thereof a therapeutically effective amount of ASBTI or a pharmaceutically acceptable salt thereof.

The present invention relates to compositions and methods for preventing or treating pruritus, prurigo, neutrophilic dermatoses and skin cancer. The invention extends to compositions for preventing or treating conditions where an exaggerated Th2 response plays a detrimental role. The invention further extends to compositions and the use of the compositions of the invention for the treatment and/or prophylaxis of pruritus, prurigo, neutrophilic dermatoses and skin cancer for Human and Veterinary therapies.

The present invention relates to compositions and methods for preventing or treating pruritus, prurigo, neutrophilic dermatoses and skin cancer. The invention extends to compositions for preventing or treating conditions where an exaggerated Th2 response plays a detrimental role. The invention further extends to compositions and the use of the compositions of the invention for the treatment and/or prophylaxis of pruritus, prurigo, neutrophilic dermatoses and skin cancer for Human and Veterinary therapies.

The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below: ##STR00001##