A method of reducing the appearance of dark circles in a periorbital area of a person's face is disclosed. The method can include topically applying to the dark circles a composition comprising an extract of Opuntia ficus-indica to reduce the appearance of the dark circles in the periorbital area of the person's face.

A pharmaceutical composition, comprising a therapeutically effective amount of an active pharmaceutical ingredient (API) compound represented by the following structural formula

##STR00001## at least one acidifying agent; and a vehicle base comprising at least one pharmaceutically acceptable non-aqueous solvent. Values and preferred values of the variables in structural formula (I) are defined herein.

6,8-Disubstituted-9-(heterocyclyl)purines for use in pharmaceutical and cosmetic compositions and applications are provided. These 6,8-disubstituted-9-(heterocyclyl)purines have a wide range of biological activities, including for example antioxidant, anti-inflammatory, anti-senescent, anti-aging, as well as well as other activities which are especially useful in pharmaceutical and cosmetic applications. Compositions may include additional excipients and auxiliary substances. Methods of treatment of animals, mammals, plants, cells, yeast, and cells in tissue culture are also disclosed.

The present invention relates to a novel method of treatment of acne in a human patient in need thereof, comprising administering topically to said patient an effective amount of the compound 3,5-Dihydroxy-4-isopropyl-trans-stilbene (Compound 1) or a pharmaceutically acceptable salt thereof.

Described are a group of isoxazol-3(2H)-one analogues and their use in topical formulations for the treatment and prophylaxis of dermatological disorders.

The present invention provides a crude extract, fractions and sub-fractions from the seaweed Fucus distichus (FD), method of preparation and its use for inhibiting the growth of microbial cells, particularly bacteria causing acne or nosocomial infections such as MRSA in humans or MRSP in dogs.

A pharmaceutical composition, comprising a therapeutically effective amount of an active pharmaceutical ingredient (API) compound represented by the following structural formula

##STR00001## at least one acidifying agent; and a vehicle base comprising at least one pharmaceutically acceptable non-aqueous solvent. Values and preferred values of the variables in structural formula (I) are defined herein.

Disclosed are an acne removal composition, a skin care product and a preparation method thereof, wherein the acne removal composition is made from Garcinia mangostana L pericarp, thyme and Fructus aurantii.

Proposed is a patch for the alleviation and prevention of acne, in which anti-acne activity of a biodegradable metal represented by Mg.sub.aZn.sub.bX.sub.c (in which a, b and c are wt % of individual components, a+b+c=100 wt %, 0≤a≤100, 0≤b≤100, and 0≤c≤10, among which a or b is the greatest, and X is at least one selected from the group consisting of Ca, Fe, Mn, Si, Na, Zr, Ce, and P) is demonstrated, thus exhibiting novel use thereof as a patch for the alleviation and prevention of acne.

Proposed is a patch for the alleviation and prevention of acne, in which anti-acne activity of a biodegradable metal represented by Mg.sub.aZn.sub.bX.sub.c (in which a, b and c are wt % of individual components, a+b+c=100 wt %, 0≤a≤100, 0≤b≤100, and 0≤c≤10, among which a or b is the greatest, and X is at least one selected from the group consisting of Ca, Fe, Mn, Si, Na, Zr, Ce, and P) is demonstrated, thus exhibiting novel use thereof as a patch for the alleviation and prevention of acne.