A method and composition for increasing muscle protein synthesis in mammals is disclosed. In one embodiment, the mammals are administered a protein building composition comprising at an amino acid derivative including L-carnitine and a nitrogenous organic acid including creatine. In a particular embodiment, the creatine is in an acid resistant capsule delivery form. The ratio of L-carnitine to creatine can be from about 10:1 to about 1:1. The protein building composition can be administered in a monolithic enteric capsule.

Pharmaceutical compositions comprising a selective TGF-β inhibitor, such as a TGFβRII-Fc, are provided herein to prevent, reverse, reduce the occurrence of and/or treat fatty degeneration of skeletal muscle. Additionally, the selective TGF-β inhibitors may be used to inhibit fibro-adipogenic progenitor cell (FAP) differentiation into adipocytes.

Pharmaceutical compositions comprising a selective TGF-β inhibitor, such as a TGFβRII-Fc, are provided herein to prevent, reverse, reduce the occurrence of and/or treat fatty degeneration of skeletal muscle. Additionally, the selective TGF-β inhibitors may be used to inhibit fibro-adipogenic progenitor cell (FAP) differentiation into adipocytes.

Provided are methods and compositions for promoting tissue (e.g., muscle) regeneration using one or more activators of fatty acid oxidation, such as one or more PPARγ activators. The methods and compositions described herein are also useful for promoting tissue growth, inducing proliferation of stem cells, inducing differentiation of tissuegenic cells (e.g., myogenic cells), and treating a disease or condition associated with a tissue (e.g., muscle), such as tissue injury, degeneration or aging, in an individual.

Provided are methods and compositions for promoting tissue (e.g., muscle) regeneration using one or more activators of fatty acid oxidation, such as one or more PPARγ activators. The methods and compositions described herein are also useful for promoting tissue growth, inducing proliferation of stem cells, inducing differentiation of tissuegenic cells (e.g., myogenic cells), and treating a disease or condition associated with a tissue (e.g., muscle), such as tissue injury, degeneration or aging, in an individual.

The disclosure provides, in part, follistatin polypeptides that are suitable for use in local administration and methods for use.

The disclosure provides, in part, follistatin polypeptides that are suitable for use in local administration and methods for use.

According to an embodiment of the present invention, provided is a composition for preventing or treating sarcopenia containing a non-natural amino acid derivative as an active ingredient.

According to an embodiment of the present invention, provided is a composition for preventing or treating sarcopenia containing a non-natural amino acid derivative as an active ingredient.

This disclosure provides compositions comprising amino acid entities. The disclosure also provides methods for increasing myogenesis, increasing muscle protein synthesis, increasing muscle mass, improving muscle quality or enhancing muscle function comprising administering an effective amount of the compositions to a subject in need thereof.