Method for preventing or treating neuropathic and/or inflammatory pain, wherein said method comprises administering at least one effective dose of the phosphorothioate oligonucleotide IMT504. The preventive method may be applied to a mammal to be subjected to a medical or surgical intervention, or to a mammal that may be injured performing a risky task (for example, a soldier in a battle) to prevent development of pain after a medical intervention or injury.

Provided herein in some embodiments are methods of treating a sleep disorder associated with pain in a patient in need thereof, comprising administering to the patient a compound of Formula (I), or a pharmaceutically acceptable salt thereof. Provided herein in some embodiments are methods of treating a sleep disorder associated with pain in a patient in need thereof, comprising: a) identifying a patient having a sleep disorder associated with pain; and b) administering to the patient identified in step a) a compound of Formula (I), or a pharmaceutically acceptable salt thereof. Provided herein in some embodiments are methods of treating a sleep disorder associated with pain in a patient in need thereof, comprising: a) selecting a patient having a sleep disorder associated with pain; and b) administering to the patient identified in step a) a compound of Formula (I), or a pharmaceutically acceptable salt thereof. In some embodiments, the sleep disorder is selected from the group consisting of difficulty with falling asleep; restlessness of sleep; difficulty getting comfortable; difficulty staying asleep; degree of deep sleep; degree of being rested when waking up for the day; difficulty with beginning the day; and degree of having enough sleep during the previous night. In some embodiments, the sleep disorder is associated with pain selected from the group consisting of fibromyalgia, neuropathic pain, osteoarthritis, and visceral pain. In some more particular embodiments, the visceral pain is selected from the group consisting of IBS associated pain and bladder pain.

Provided is a composition for oral administration which includes a lipophilic active substance and a phospholipid, providing a prolonged therapeutic effect.

Provided is a composition for oral administration which includes a lipophilic active substance and a phospholipid, providing a prolonged therapeutic effect.

A bioconjugate comprising at least one neuropeptide covalently bond to at least one hydrocarbon compound of squalene structure.

A bioconjugate comprising at least one neuropeptide covalently bond to at least one hydrocarbon compound of squalene structure.

The present invention aims to provide a therapeutic agent for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and fibromyalgia.

A therapeutic agent for a disease selected from myalgic encephalomyelitis/chronic fatigue syndrome, and fibromyalgia. containing 2-amino-2-[2-(4-heptyloxy-3-trifluoromethylphenyl)ethyl]propane-1,3-diol or a pharmaceutically acceptable salt thereof.

Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein -------, R.sup.1, R.sup.2, R.sup.5, A and L are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia. ##STR00001##

Disclosed herein are compounds of formula (I)

##STR00001##

and therapeutic methods of treatment with compounds of formula (I), wherein L.sup.1, L.sup.2, L.sup.4, R.sup.1, R.sup.4, R.sup.5, R.sup.6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, neuropathic pain, and related disorders.

Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.